Identification of fibroblast growth factor receptor 3 as a protein receptor for botulinum neurotoxin serotype A

Botulinum toxin A, brain and pain

“…Subsequently, the toxin heavy chain binds its high affinity membrane protein acceptors, synaptic vesicle protein 2 (SV2) and fibroblast growth factor receptor 3, which govern BoNT/A binding and endocytotic entry into neurons (Dong et al, 2006;Jacky et al, 2013;Mahrhold et al, 2006). BoNT/A internalization into neurons may be mediated by all isoforms of SV2 (SV2 A-C), with the strongest affinity for SV2C (Dong et al, 2006).…”