Identification of ferroptosis‐related genes as potential biomarkers of tongue squamous cell carcinoma using an integrated bioinformatics approach

Zhu, Huilian; Tao, Yuzhi; Huang, Qiu‐An; Chen, Zhuoming; Jiang, Liangfu; Yan, Haolin; Zhong, Jinghua; Liang, Leifeng

doi:10.1002/2211-5463.13348

Cited by 5 publications

(3 citation statements)

References 53 publications

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“…Ferroptosis may contribute to hypertensive nephropathy through processes such as drug metabolism‐cytochrome P450, branched‐chain amino acid (BCAA) metabolism, retinol metabolism, organic and amino acid metabolism, humoral immunity, and more 35,36 . It has been reported that ferroptosis‐related genes may impact the prognosis of tongue squamous cell carcinoma (TSCC) through the IL‐17 signaling pathway 37 . The regulation of ferroptosis‐related enzymes, metabolism, and associated signaling pathways offers promising perspectives for the development of novel anticancer therapeutics.…”

Section: Discussionmentioning

confidence: 99%

“… 35 , 36 It has been reported that ferroptosis‐related genes may impact the prognosis of tongue squamous cell carcinoma (TSCC) through the IL‐17 signaling pathway. 37 The regulation of ferroptosis‐related enzymes, metabolism, and associated signaling pathways offers promising perspectives for the development of novel anticancer therapeutics.…”

Section: Discussionmentioning

confidence: 99%

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A ferroptosis‐related LncRNAs signature for predicting prognoses and screening potential therapeutic drugs in patients with lung adenocarcinoma: A retrospective study

Dong,

Tao,

et al. 2023

Cancer Reports

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BackgroundLung adenocarcinoma (LUAD) has a high mortality rate. Ferroptosis is linked to tumor initiation and progression.AimsThis study aims to develop prognostic models of ferroptosis‐related lncRNAs, evaluate the correlation between differentially expressed genes and tumor microenvironment, and identify prospective drugs for managing LUAD.Methods and ResultsIn this study, transcriptomic and clinical data were downloaded from the TCGA database, and ferroptosis‐related genes were obtained from the FerrDb database. Through correlation analysis, Cox analysis, and the LASSO algorithm for constructing a prognostic model, we found that ferroptosis‐related lncRNA‐based gene signatures (FLncSig) had a strong prognostic predicting ability in the LUAD patients. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichments reconfirmed that ferroptosis is related to receptor‐ligand activity, enzyme inhibitor activity, and the IL‐17 signaling pathway. Next, tumor mutation burden (TMB), tumor immune dysfunction and exclusion (TIDE) algorithms, and pRRophetic were used to predict immunotherapy response and chemotherapy sensitivity. The IMvigor210 cohort was also used to validate the prognostic model. In the tumor microenvironment, Type_II_IFN_Response and HLA were found to be a group of low‐risk pathways, while MHC_class_I was a group of high‐risk pathways. Patients in the high‐risk subgroup had lower TIDE scores. Exclusion, MDSC, CAF, and TAMM2 were significantly and positively correlated with risk scores. In addition, we found 15 potential therapeutic drugs for LUAD. Finally, differential analysis of stemness index based on mRNA expression (mRNAsi) indicated that mRNAsi was correlated with gender, primary tumor (T), distant metastasis (M), and the tumor, node, and metastasis (TNM) stage in LUAD patients.ConclusionsIn conclusion, the prognostic model based on FLncSig can alleviate the difficulty in predicting the prognosis and immunotherapy of LUAD patients. The identified FLncSig and the screened drugs exhibit potential for clinical application and provide references for the treatment of LUAD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A ferroptosis‐related LncRNAs signature for predicting prognoses and screening potential therapeutic drugs in patients with lung adenocarcinoma: A retrospective study

Dong,

Tao,

et al. 2023

Cancer Reports

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“…High FPscore groups in OSCC were associated with better prognosis, activation of a ferroptosis-related immune phenotype, and better response to chemo and immunotherapy. Overall, common findings of prognosisrelated ferroptosis-associated genes were ferritin heavy chain 1 (FTH1) [47], autophagy related 5 (ATG5) [26,51], arachidonate 15-lipoxygenase (ALOX15) [26,51], microtubule associated protein 1 light chain 3 alpha (MAP1LC3A) [26,51], mitogen-activated protein kinase kinase kinase 5 (MAP3K5) [26], and carbonic anhydrase 9 (CA9) [49,51]. According to Yin et al [47], the main genes whose increased expression would be correlated with poor prognosis are, besides FTH1 and ATG5, BCL2 interacting protein 3 (BNIP3) and peroxiredoxin 6 (PRDX6).…”

Section: Ferroptosismentioning

confidence: 99%

Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review

Siquara da Rocha,

de Morais,

de Oliveira

et al. 2024

Biology

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Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head and neck cancer in the world. Variable response and acquisition of resistance to traditional therapies show that it is essential to develop novel strategies that can provide better outcomes for the patient. Understanding of cellular and molecular mechanisms of cell death control has increased rapidly in recent years. Activation of cell death pathways, such as the emerging forms of non-apoptotic programmed cell death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis and paraptosis, may represent clinically relevant novel therapeutic opportunities. This systematic review summarizes the recently described forms of cell death in OSCC, highlighting their potential for informing diagnosis, prognosis and treatment. Original studies that explored any of the selected cell deaths in OSCC were included. Electronic search, study selection, data collection and risk of bias assessment tools were realized. The literature search was carried out in four databases, and the extracted data from 79 articles were categorized and grouped by type of cell death. Ferroptosis, pyroptosis, and necroptosis represented the main forms of cell death in the selected studies, with links to cancer immunity and inflammatory responses, progression and prognosis of OSCC. Harnessing the potential of these pathways may be useful in patient-specific prognosis and individualized therapy. We provide perspectives on how these different cell death types can be integrated to develop decision tools for diagnosis, prognosis, and treatment of OSCC.

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Current knowledge of ferroptosis in the pathogenesis and prognosis of oral squamous cell carcinoma

Zhou,

Wu,

Ying

et al. 2024

Cellular Signalling

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Identification of ferroptosis‐related genes as potential biomarkers of tongue squamous cell carcinoma using an integrated bioinformatics approach

Abstract: Haisheng Zhu and Yuzhi Tao contributed equally to this article.

Cited by 5 publications

References 53 publications

A ferroptosis‐related LncRNAs signature for predicting prognoses and screening potential therapeutic drugs in patients with lung adenocarcinoma: A retrospective study

A ferroptosis‐related LncRNAs signature for predicting prognoses and screening potential therapeutic drugs in patients with lung adenocarcinoma: A retrospective study

Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review

Current knowledge of ferroptosis in the pathogenesis and prognosis of oral squamous cell carcinoma

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