Identification of extracellular matrix-related biomarkers in colon adenocarcinoma by bioinformatics and experimental validation
Yongkui Yin,
Xiaojie Yang,
Zhengyi Cheng
et al.
Abstract:BackgroundsExtracellular matrix (ECM) is an important component of tumor microenvironment, and its abnormal expression promotes tumor formation, progression and metastasis.MethodsWeighted gene co-expression network analysis (WGCNA) was used to identify ECM-related hub genes based on The Cancer Genome Atlas (TCGA) colon adenocarcinoma (COAD) data. COAD clinical samples were used to verify the expression of potential biomarkers in tumor tissues, and siRNA was used to explore the role of potential biomarkers in c… Show more
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