Identification of European Allergy Patterns to the Allergen Families PR-10, LTP, and Profilin from Rosaceae Fruits

Abstract

High fruit intakes are associated with significant health benefits but fruit allergy sufferers may be discouraged from eating fruit due to the symptoms they experience. Knowledge about allergens involved in fruit allergy and the frequent cross-reactions to other allergens is essential to (a) design the best strategy for fruit allergy testing (b) prescribe optimal avoidance diets, and (c) design technological solutions for development of hypoallergenic fruits. The objective of this review was to investigate whether some characteristic disease entities could be identified in Europe for allergy to Rosaceae fruits. Five allergy patterns were found involving the allergen families PR-10, LTP, and profilin. In the Western Mediterranean area allergies to Rosaceae fruits are caused by monosensitization to LTP, monosensitization to profilin, or co-sensitization to both these allergens. On the contrary, monosensitization to PR-10 and, to a lesser degree, co-sensitization to profilin and PR-10 is dominant in Northern and Central Europe. LTP sensitization is present both in pollinosis and non-pollinosis patients and is associated with peach allergy in particular. The disease pattern for patients sensitized to profilin is characterized by several concomitant allergies including grass and other pollens, Rosaceae and non-Rosaceae fruits. Finally, PR-10 sensitization is primarily associated to concomitant birch pollen and apple allergy.

Component-Resolved Diagnosis of Peanut Allergy and Its Possible Origins of Sensitization in China

“…In Spain for example, peanut-allergic patients are more often sensitized to the nonspecific lipid transfer protein (nsLTP) Ara h 9 in peanuts, and peanut allergy (PA) always follows other plant-derived food allergies, like peach [4,5]. On the other hand, Swedish patients had relatively high IgE-positive responses to Ara h 8, a member of the PR-10 family and Bet v 1 homologue, which may be correlated with a high prevalence of birch pollinosis [6] and rarity of severe reactions. Ara h 1 and 2 are major peanut allergens in Austria, where anaphylaxis is the most common peanut-associated reaction [7].…”

Immunohisto- and cytochemical localization of PR-10 proteins induced by heavy metals in lupine roots

“…The presence or accumulation of pr10 genes expression products, mostly under stress conditions, has been demonstrated in roots and leaves (Bantignies et al 2000;Przymusiński et al 2004;Utriainen et al 1998), hypocotyls (Gzyl et al 1997), tuber (Flores et al 2002), stems, seeds (Iturriaga et al 1994), fruits (Andersen et al 2011), embryos and pollen (Swoboda et al 1994), stigma (Constabel and Brisson 1995), calluses (Moiseyev et al 1997), and cell suspension (Carpin et al 1998). These data suggest that PR-10 proteins might be potentially accumulated in all organs of plants and are in line with our earlier study (Przymusiński et al 2001) in which the localization of PR (L1-L6) proteins with a tissue printing method was investigated in 12-day-old lupine seedlings, but excluding the root tips.…”

New Food Allergies in a European Non-Mediterranean Region: Is <b><i>Cannabis sativa</i></b> to Blame?

“…Today, it appears that fruit and vegetable allergies exhibit geographic and age-related variation regarding the severity of symptoms and depending on the sensitization profile of the patient. In Belgium, as in most other north European regions, plant food allergy in adults is generally characterized by an oral allergy syndrome (OAS) due to sensitization to the labile homologues of Bet v 1, the major allergen from birch (Betula verrucosa) pollen [3,4,5,6,7,8]. In contrast, children frequently demonstrate more severe and generalized reactions that are generally not related to pollen allergy but are frequently due to sensitization to different seed-storage proteins (e.g.…”

“…In contrast, in the Mediterranean non-birch endemic region plant food allergy originates frequently from sensitization to nonspecific lipid transfer proteins (ns-LTPs), another member of the prolamin superfamily [4,7,8,10]. Different ns-LTPs have been identified in various foods including Rosaceae, nuts, peanuts and cereals [11,12].…”