Identification of estrogenic/anti‐estrogenic compounds in diesel exhaust particulate extract

Noguchi, Keiko; Toriba, Akira; Chung, Sang Woon; Kizu, Ryoichi; Hayakawa, Kazuichi

doi:10.1002/bmc.861

Cited by 23 publications

(17 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…contained in PM, especially from diesel exhaust [12,13], are described in the literature as endocrine disruptors with either estrogenic, antiestrogenic or anti-androgenic activity [14,[77][78][79][80][81]. Kizu et al described anti-androgenic activity of certain particle compounds from diesel exhaust in human PC3/ AR cells derived from prostate cancer tumors [15], while Okamura et al reported anti-estrogenic activity of similar compounds in human MCF-7 cells from breast cancer tumors [14].…”

Section: Action As Endocrine Disruptorsmentioning

confidence: 99%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

View full text Add to dashboard Cite

Background: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O 3 or NO 2 or PM2.5 or diesel or SO 2 or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved.

show abstract

Section: Action As Endocrine Disruptorsmentioning

confidence: 99%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Sources of these chemicals in the marine environment include direct input from combustion [1] and sewage effluents [7]. Parent PAH released into the environment can also undergo oxidation as a result of thermal and ultraviolet irradiation [8].…”

Section: Introductionmentioning

confidence: 99%

“…PAH exposure has also been linked to community-level toxic effects such as reduced viability and food web disruption [4]. In addition to being good model compounds and abundant in the environment, PY and PYOH also exhibit many of these toxicities [1,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bioaccumulation and biotransformation of pyrene and 1‐hydroxypyrene by the marine whelk Buccinum undatum

Beach

Quilliam

Rouleau

et al. 2010

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

The fates of a phenolic contaminant and its hydrocarbon precursor have rarely been compared, especially in an invertebrate species. Two groups of Buccinum undatum were exposed to equimolar amounts of pyrene and 1‐hydroxypyrene over 15 d through their diets. Tissue extracts from the muscle and visceral mass were analyzed by liquid chromatography with fluorescence and mass spectrometry detection. Nine biotransformation products were detected in animals from both exposures. These included 1‐hydroxypyrene, pyrene‐1‐sulfate, pyrene‐1‐glucuronide, pyrene glucose sulfate, two isomers each of pyrenediol sulfate and pyrenediol disulfate, and one isomer of pyrenediol glucuronide sulfate. These compounds represent a more complex metabolic pathway for pyrene than is typically reported. Diconjugated metabolites were as important in animals exposed to pyrene as in those exposed to 1‐hydroxypyrene. Biotransformation products represented >90% of the material detected in the animals and highlight the importance of analyzing metabolites when assessing exposure. A mean of only 2 to 3% of the body burden was present in muscle compared with the visceral mass of both groups. The analytical methods were sufficiently sensitive to detect biotransformation products both in laboratory control whelks and in those sampled offshore. The tissue distribution of [14C]pyrene was also studied by autoradiography. Radioactivity was present primarily in the digestive and excretory system of the whelks and not in the gonads or muscle tissue. Environ. Toxicol. Chem. 2010;29:779–788. © 2009 SETAC

show abstract

“…Miscellaneous compounds found in DEP are among endocrine impairing chemicals, which exhibit estrogenic and anti-androgenic activities [2][3][4][5] . DEP compounds were reported to have adverse effects on reproductive system and impair both reproductive and endocrine functions in male mice and rats [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Sıçan Testisinde 3-Metil-4-Nitrofenol İle Oluşturulan Hasara Karşı Morinda citrifolia (Noni)’nın Koruyucu Etkisi

Yigit¹,

Armutak²,

Esener³

et al. 2016

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

In this study, the protective effect of Morinda citrifolia (Noni) against 3-methyl-4-nitrophenol (PNMC) toxicity in rat testes was investigated with an experimental period of five days. Fifty-six adult male Sprague-Dawley rats were allocated into seven experimental groups and a control (n:7). One group received only Noni. Testicular tissue injury of six experimental groups was induced by subcutaneous injection of PNMC at three different doses (1, 10 and 100 mg/kg) and three received Noni treatment (2 ml per rat by gavage). On day six all rats were sacrificed and then blood samples and testis tissues were collected. Serum testosterone, FSH and LH levels were assessed. Testicular tissues were evaluated histomorphometrically in terms of tubular diameter, seminiferous epithelium density, luminal space and interstitial tissue and immunohistochemically labelled with inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) markers to assess oxidative damage. Histomorphometrically, most severe tissue injury was observed in the group of 10 mg/kg PNMC. Tissue injury improved significantly in its corresponding treatment group (with Noni). iNOS and eNOS levels increased in all PNMC groups and decreased with Noni treatments. Noni was most effective in the group of 100mg/kg PNMC in terms of oxidative damage. Serum hormone levels revealed no significant results. In conclusion, Noni reduced PNMC-induced tissue injury in rat testes. Rat, Noni, Testes, iNOS, eNOS Keywords: Sıçan Testisinde 3-Metil-4-Nitrofenol İle Oluşturulan Hasara Karşı Morinda citrifolia (Noni)'nın Koruyucu Etkisi ÖzetBu çalışmada beş günlük deneysel bir periyotla Morinda citrifolia (Noni)'nın sıçan testislerinde 3-metil 4-nitrofenol (PNMC) toksisitesine karşı koruyucu etkisi araştırıldı. Ellialtı adet yetişkin erkek Sprague-Dawley sıçanı eşit sayıda yedi deneysel, bir kontrol grubuna ayrıldı (n:7). Bir gruba sadece Noni uygulandı. Altı deneysel grupta testiste doku hasarı farklı dozlarda (1, 10 and 100 mg/kg) subkutan PNMC enjeksiyonu ile indüklendi ve üç gruba Noni tedavisi uygulandı (her sıçan için 2ml gavaj ile). Altıncı günde tüm sıçanlar sakrifiye edilerek kan ve testis doku örnekleri toplandı. Serum testosteron, FSH ve LH seviyeleri değerlendirildi. Testis dokuları, tubuler çap, seminifer epitel yoğunluğu, lumen aralığı ve interstisyel doku açısından histomorfometrik olarak incelendi ve oksitatif hasarı değerlendirmek üzere indüklenebilir nitrik oksit sentaz (iNOS) ve endotelyal nitrik oksit sentaz (eNOS) belirteçleri ile immunohistokimyasal olarak işaretlendi. Histomorfometrik olarak en şiddetli doku hasarı 10 mg/kg'lık PNMC grubunda gözlendi. Doku hasarı bu gruba karşılık gelen tedavi (Noni ile) grubunda anlamlı ölçüde iyileşti. iNOS ve eNOS düzeyleri tüm PNMC gruplarında yükseldi ve Noni tedavisi ile aynı değerler düşüş gösterdi. Noni'nin oksidatif hasar bakımından en çok 100mg/kg'lık PNMC grubunda etkin olduğu izlendi. Serum hormon değerleri anlamlı sonuçlar vermedi. Sonuç olarak, Noni, sıçan testislerinde PNM...

show abstract

Identification of estrogenic/anti‐estrogenic compounds in diesel exhaust particulate extract

Cited by 23 publications

References 26 publications

Does air pollution play a role in infertility?: a systematic review

Does air pollution play a role in infertility?: a systematic review

Bioaccumulation and biotransformation of pyrene and 1‐hydroxypyrene by the marine whelk Buccinum undatum

Sıçan Testisinde 3-Metil-4-Nitrofenol İle Oluşturulan Hasara Karşı Morinda citrifolia (Noni)’nın Koruyucu Etkisi

Contact Info

Product

Resources

About