Identification of estrogenic and antiestrogenic activities of respirable diesel exhaust particles by bioassay-directed fractionation

Oh, Seung Min; Ryu, Byung Taek; Chung, Kyu Hyuck

doi:10.1007/s12272-008-1123-8

Cited by 31 publications

(20 citation statements)

References 45 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In regards to this type of analysis, sample screening was performed by using a yeast estrogen screen (YES) assay for total estrogenic activity; then, the analysis for specific chemical species was conducted by using LC-MS/MS [85,111]. Another application method was bioassay-directed fractionation, which consists of a cell bioassay (E-SCREEN), in conjunction with acid-base partitioning (F1 and F2) and the silica gel column fractionation of neutral fractions (F3-F7) [112]. In addition, the recombinant yeast assay (RYA), combined with chemical identification by LC-MS, was used [113].…”

Section: Liquid Phase Microextraction Methodsmentioning

confidence: 99%

The methods of identification, analysis, and removal of endocrine disrupting compounds (EDCs) in water

Chang

Choo

Lee

et al. 2009

Journal of Hazardous Materials

341

136

View full text Add to dashboard Cite

Section: Liquid Phase Microextraction Methodsmentioning

confidence: 99%

The methods of identification, analysis, and removal of endocrine disrupting compounds (EDCs) in water

Chang

Choo

Lee

et al. 2009

Journal of Hazardous Materials

341

136

View full text Add to dashboard Cite

“…contained in PM, especially from diesel exhaust [12,13], are described in the literature as endocrine disruptors with either estrogenic, antiestrogenic or anti-androgenic activity [14,[77][78][79][80][81]. Kizu et al described anti-androgenic activity of certain particle compounds from diesel exhaust in human PC3/ AR cells derived from prostate cancer tumors [15], while Okamura et al reported anti-estrogenic activity of similar compounds in human MCF-7 cells from breast cancer tumors [14].…”

Section: Action As Endocrine Disruptorsmentioning

confidence: 99%

“…These hormone disruptions may be induced by air pollutants, notably PAHs, binding to estrogen receptors [78,79,82,83] or androgen receptors [15,84] with an agonistic or antagonistic effect. They may also be the result of activation of AhR pathway.…”

Section: Action As Endocrine Disruptorsmentioning

confidence: 99%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

View full text Add to dashboard Cite

Background: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O 3 or NO 2 or PM2.5 or diesel or SO 2 or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved.

show abstract

“…Substances that cross the placenta and/or are secreted into milk might reach the brains of embryos or neonates while the blood-brain barrier is immature (Dalgaard et al 2001;Oh et al 2008). Thus, the possibility that exposure to EDC influences the central nervous system (CNS) or leads to neurodegenerative disorders in adulthood cannot be ruled out.…”

mentioning

confidence: 99%

Neurotoxicity of Endocrine Disruptors: Possible Involvement in Brain Development and Neurodegeneration

Masuo

Ishido

2011

Journal of Toxicology and Environmental Health, Part B

107

View full text Add to dashboard Cite

Environmental chemicals that act as endocrine disruptors do not appear to pose a risk to human reproduction; however, their effects on the central nervous systems are less well understood. Animal studies suggested that maternal exposure to endocrine-disrupting chemicals (EDC) produced changes in rearing behavior, locomotion, anxiety, and learning/memory in offspring, as well as neuronal abnormalities. Some investigations suggested that EDC exert effects on central monoaminergic neurons, especially dopaminergic neurons. Our data demonstrated that EDC attenuate the development of dopaminergic neurons, which might be involved in developmental disorders. Perinatal exposure to EDC might affect neuronal plasticity in the hippocampus, thereby potentially modulating neuronal development, leading to impaired cognitive and memory functions. Endocrine disruptors also attenuate gender differences in brain development. For example, the locus ceruleus is larger in female rats than in males, but treatments with bisphenol-A (BPA) enlarge this region in males. Some reports indicated that EDC induce hypothyroidism, which might be evidenced as abnormal brain development. Endocrine disruptors might also affect mature neurons, resulting in neurodegenerative disorders such as Parkinson's disease. The current review focused on alterations in the brain induced by EDC, specifically on the possible involvement of EDC in brain development and neurodegeneration.

show abstract

Identification of estrogenic and antiestrogenic activities of respirable diesel exhaust particles by bioassay-directed fractionation

Cited by 31 publications

References 45 publications

The methods of identification, analysis, and removal of endocrine disrupting compounds (EDCs) in water

The methods of identification, analysis, and removal of endocrine disrupting compounds (EDCs) in water

Does air pollution play a role in infertility?: a systematic review

Neurotoxicity of Endocrine Disruptors: Possible Involvement in Brain Development and Neurodegeneration

Contact Info

Product

Resources

About