Identification of essential sequences for cellular localization in the muscle‐specific ubiquitin E3 ligase MAFbx/Atrogin 1

Lagirand-Cantaloube, Julie; Batonnet-Pichon, Sabrina; Marie-Pierre, Leibovitch; Leibovitch, Serge A.

doi:10.1016/j.febslet.2011.12.031

Cited by 15 publications

(8 citation statements)

References 21 publications

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“…Our Western blot using atrogin-1 antibody could not detect a significant decrease after resveratrol supplementation. Since atrogin-1 exhibits movable components between the nucleus and cytosol 31 , atrogin-1 only changes the localization and does not cause volumetric changes. The protein analysis in this study was conducted to utilize crude homogenate using whole muscle but not fractionated homogenate with the division of components such as the nucleus, cytosol, and membrane.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol attenuates denervation-induced muscle atrophy due to the blockade of atrogin-1 and p62 accumulation

et al. 2018

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Decrease in activity stress induces skeletal muscle atrophy. A previous study showed that treatment with resveratrol inhibits muscular atrophy in mdx mice, a model of DMD. However, almost all studies using resveratrol supplementation have only looked at adaptive changes in the muscle weight. The present study was designed to elucidate whether the resveratrol-inducing attenuation of skeletal muscle actually reflects the adaptation of muscle fibers themselves, based on the modulation of atrogin-1- or p62-dependent signaling. Mice were fed either a normal diet or 0.5% resveratrol diet. One week later, the right sciatic nerve was cut. The wet weight, mean fiber area, and amount of atrogin-1 and p62 proteins were examined in the gastrocnemius muscle at 14 days after denervation. The 0.5% resveratrol diet significantly prevented denervation-induced decreases in both the muscle weight and fiber atrophy. In addition, dietary resveratrol suppressed the denervation-induced atrogin-1 and p62 immunoreactivity. In contrast, 0.5% resveratrol supplementation did not significantly modulate the total protein amount of atrogin-1 or p62 in the denervated muscle of mice. Resveratrol supplementation significantly prevents muscle atrophy after denervation in mice, possibly due to the decrease in atrogin-1 and p62-dependent signaling.

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Section: Discussionmentioning

confidence: 99%

Resveratrol attenuates denervation-induced muscle atrophy due to the blockade of atrogin-1 and p62 accumulation

et al. 2018

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“…FBXO32 lacks leucine-rich repeats or WD40 repeats but it does contain a class II PDZ domain (2), which interacts with specific sequences at the carboxyl terminus of the target proteins (3,4). In addition, FBXO32 also contains two nuclear localization signals, which suggests that it may target transcription factors or other nuclear proteins for ubiquitination (5).…”

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confidence: 99%

FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity

Mei

Zhang

et al. 2015

Journal of Biological Chemistry

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“…Other E3 ubiquitin ligases, such as Smurf2 [55], FBXW7 [56], HERC2 [57], or MAFbx [58], have been shown to change intracellular localization upon certain stimuli. Such protein translocation between different subcellular compartments is an essential part of biological and pathological processes.…”

Section: Discussionmentioning

confidence: 99%

Pellino‐2 in nonimmune cells: novel interaction partners and intracellular localization

et al. 2021

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Pellino‐2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino‐2 have been performed in macrophages, but none in nonimmune cells. Using yeast two‐hybrid screening and co‐immunoprecipitation, we identified six novel interaction partners of Pellino‐2, with various localizations: insulin receptor substrate 1, NIMA‐related kinase 9, tumor necrosis factor receptor‐associated factor 7, cyclin‐F, roundabout homolog 1, and disheveled homolog 2. Pellino‐2 showed cytoplasmic localization in a wide range of nonimmune cells under physiological potassium concentrations. Treatment with the potassium ionophore nigericin resulted in nuclear localization of Pellino‐2, which was reversed by the potassium channel blocker tetraethylammonium. Live‐cell imaging revealed intracellular migration of GFP‐tagged Pellino‐2. In summary, Pellino‐2 interacts with proteins at different cellular locations, taking part in dynamic processes that change its intracellular localization influenced by potassium efflux.

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Identification of essential sequences for cellular localization in the muscle‐specific ubiquitin E3 ligase MAFbx/Atrogin 1

Cited by 15 publications

References 21 publications

Resveratrol attenuates denervation-induced muscle atrophy due to the blockade of atrogin-1 and p62 accumulation

Resveratrol attenuates denervation-induced muscle atrophy due to the blockade of atrogin-1 and p62 accumulation

FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity

Pellino‐2 in nonimmune cells: novel interaction partners and intracellular localization

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