“…With regard to the genes specifically up-regulated in the MCSP CTC fraction, the majority have been involved in metastasis ( LOXL4, ST6GALNAC2, PYGL) , tumour growth ( PLK2 , CYSTM1, GLUL ), and/or melanoma biology ( SEC31A, WIPI1 , SKP1 ) [42,43,45,46,47,48,49,50,51,52,53]. Similarly, the up-regulated genes in the ABCB5 CTC fractions were involved in metastasis ( CALU , CYB5R1, DUSP3, CREG1, ENDOD1 ), tumour growth, and/or melanoma biology ( H1F0, SCNA, WIPI1, TXN2 ) [42,43,54,55,56,57,58,59,60]. These findings support the suggestion that these two CTC subpopulations exhibit different gene expression patterns but similar molecular mechanisms underlying their biology.…”