Abstract:ID 18183 Poster Board 577Kidney is one of the major drug-elimination organs. The total renal excretion of a compound is the net result of glomerular filtration, tubular secretion, and reabsorption. Tubular secretion is a transporter-mediated process, which is often mediated by organic cation transporters (OCT/Oct) that facilitate the active secretion of several cationic substrates including drugs such as metformin as well as endogenous cations 1 . Endogenous biomarkers of OCTs can help in the early assessment … Show more
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