Identification of eight genomic protective alleles for mitochondrial diabetes by Kinship‐graph convolutional network
Jiahao Wang,
Dandan Yan,
Haoyue Cui
et al.
Abstract:AimsNearly 85% of maternally inherited diabetes and deafness (MIDD) are caused by the m.3243A>G mutation in the mitochondrial DNA. However, the clinical phenotypes of MIDD may also be influenced by the nuclear genome, this study aimed to investigate nuclear genome variants that influence clinical phenotypes associated with m.3243A>G mutation in MIDD based on whole‐genome sequencing of the patients belonging to pedigrees.Materials and MethodsWe analyzed a whole‐genome sequencing (WGS) dataset from blood s… Show more
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