Identification of ectopic ovotestis in a dog with <scp>XX</scp> ovotesticular, <i><scp>SRY</scp></i>‐negative, disorder of sexual development

Amorim, Mariana Diel de; Lerer, Assaf; Durzi, Tiffany; Foster, R A; Gartley, CJ

doi:10.1111/rda.13174

Cited by 2 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, these small patches of ovarian tissue are limited to some areas of the gonadal cortex, for which multiple non-continuous sections of the gonad are needed to establish a sound histological diagnosis of ovotestis. In some cases, the existence of antral follicles or corpora lutea have been described [22], as well as the existence of ovarian cycles [8,23]. However, according to available reports, most XX;SRY-negative dogs never experienced estrus [9,25].…”

mentioning

confidence: 99%

Disturbed Ovarian Differentiation in XX;SRY-Negative Dogs

Payan-Carreira¹

2018

obm genet

View full text Add to dashboard Cite

In a mammal, at the beginning of its development, the gonad is bipotential. The shift into a male or female pathway is coordinated by the sex chromosomal complement, which triggers a series of genetic pathways signaling the developmental pattern of the gonadal anlage. Being mutually exclusive, the differentiated gonad should be either a testis or an ovary. In females, the absence of SRY, a testis-determining gene, drives the signaling cascades controlling the ovarian differentiation. Albeit rare, disorders of the gonadal differentiation may occur in men and domestic animals and may cause infertility or sterility. In dogs, the XX;SRY-negative disorder of sexual development (DSD) is the most frequent condition. The disorder typically presents a wide spectrum of developmental conditions of the gonad and variable virilization of the genital phenotype, that may be accompanied by hypospadias. This condition may be inherited as a sex-limited autosomal recessive trait; however, the mechanism explaining its occurrence remains poorly understood. This review intends to present an overview of the morphologic features of XX;SRY-negative syndrome in dogs, while addressing the current knowledge regarding the genetic mechanism underlying this condition.

show abstract

mentioning

confidence: 99%

Disturbed Ovarian Differentiation in XX;SRY-Negative Dogs

Payan-Carreira¹

2018

obm genet

View full text Add to dashboard Cite

show abstract

“…It can also be the result of dropping a tissue fragment into the surgical site or failing to identify and remove ectopic ovarian tissue. [4][5][6] Studies on surgical complications of postOHE reported that 17 -43% of the referral cases, presented for postoperative complications after ovariohysterectomy, were for ORS. 7,8 Animal's age, breed, body condition, whether the surgical procedure was elective or emergent, and the experience of the surgeon were not associated with a higher likelihood of ORS.…”

Section: Introductionmentioning

confidence: 99%

Ovarian remnant syndrome in small animals: case series

Mullikin¹,

Byron

Chen

et al. 2022

View full text Add to dashboard Cite

Our objective was to report the utility of various diagnostic tests in identifying ovarian remnant syndrome (ORS) in dogs and cats. Medical records from 2 referral teaching hospitals (Health Sciences Centre at the Ontario Veterinary College and Cornell University Hospital for Animals) were examined and 48 animals (31 dogs and 17 cats) were chosen. Data included were based on sufficient clinical or diagnostic evidence of ORS. Histopathology was used as the confirmatory test for ORS. There was no difference between the proportions of dogs versus cats diagnosed with ORS. Similarly, there was no difference in the proportions of ovarian remnants (OR) between large, medium, or small dogs, or the side (right, left, or bilateral) in which OR was diagnosed. Vaginal cytology and transabdominal ultrasonography findings, and serum progesterone concentrations had the highest chance of correctly identifying an OR prior to exploratory surgery. Transabdominal ultrasonography had strong agreement with OR location identified at surgery. Presumptive intraoperative diagnosis of OR was possible in 39/41 cases (95.1%). Auxiliary diagnostic testing should be recommended to confirm functional ovarian tissue before surgery to reduce unnecessary surgery. Additionally, transabdominal ultrasonography examination may reduce surgical time since ovarian remnant location has strong agreement with surgical findings.

show abstract

Identification of ectopic ovotestis in a dog with XX ovotesticular, SRY‐negative, disorder of sexual development

Cited by 2 publications

References 14 publications

Disturbed Ovarian Differentiation in XX;SRY-Negative Dogs

Disturbed Ovarian Differentiation in XX;SRY-Negative Dogs

Ovarian remnant syndrome in small animals: case series

Contact Info

Product

Resources

About