Identification of echinacoside as a tobramycin potentiator againstPseudomonas aeruginosaaggregates
Yu-Ming Cai,
Aurélie Crabbé,
Tom Coenye
Abstract:Cyclic diguanylate (c-di-GMP) is a central biofilm regulator, where increased intracellular levels promote biofilm formation and antibiotic tolerance. Targeting the c-di-GMP network is a promising anti-biofilm approach. Most agents reported previously decreased c-di-GMP to eliminate surface-attached biofilms, which did not recapitulate in vivo biofilms well and may thus impede their clinical impact. Here, the expression profile of genes encoding proteins associated with c-di-GMP metabolism was analysed among 3… Show more
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