Identification of early complications following pancreas and renal transplantation using contrast enhanced ultrasound (CEUS) – first results

Abstract

AIM: Identification of acute and subacute complications following pancreas and renal transplantation using contrast enhanced ultrasound (CEUS) in comparison with Magnetic Resonance Tomography (MRI), Computed Tomography (CT), Digital Subtraction Angiography (DSA) or Ultrasound (US). The study evaluated whether CEUS could confirm the preliminary diagnosis or even provide additional information, relevant for the therapeutic strategy. MATERIAL AND METHODS: Retrospective evaluation of 19 patients (13 male, 6 female, age 26-77 years, mean 53.2 years) following renal transplantation and 10 patients (4 male, 6 female, age 35-56 years, mean 45.7 years) following combined pancreas and renal transplantation. CEUS was used as an additional diagnostic method when obscure diagnostic findings occurred in US, CT, MRI or DSA. Fundamental B-scan, Color Coded Doppler Sonography (CCDS) and CEUS were performed in all patients by an experienced examiner using a multifrequency convex transducer (1-5 MHz). After a bolus injection of up to 2.4 ml SonoVue ® [BRACCO, Italy] digital raw data was stored as cine-loops up to 5 minutes in length. RESULTS: In all patients, the pathological features and suspected diagnostic findings identified in the other imaging modalities could be confirmed using CEUS (100%). In 25 out of 29 patients (86.2%), new clinically relevant findings were detected. In 27 patients, the diagnosis of CEUS was confirmed during surgery (7), DSA (5), follow-up CEUS (13), CT (1) and MRI (1). In 4 patients renal AV-fistulas were found following biopsy, 3 patients showed post-operative allograft arterial stenosis or dissection, 1 patient demonstrated a stenosis of the common iliac artery and 2 patients were diagnosed with post-operative allograft venous thrombosis or stenosis. In 2 patients, a definite diagnosis of a benign lesion following renal transplantation was possible. In 1 patient a malignant lesion was suspected and confirmed following surgery. In 6 patients, normal perfusion of the pancreas and renal parenchyma and the corresponding vessels was diagnosed, in 5 patients the parenchymal perfusion was diminished and 1 patient suffered from pancreatitis. CONCLUSION: These first results show that CEUS can provide additional, clinically relevant informations in patients with acute and subacute complications following pancreas and renal transplantation. Thus, an early application within the diagnostic course seems favorable.

Evaluation of hepatic vascular endothelial injury during liver storage by molecular detection and targeted contrast‐enhanced ultrasound imaging

“…This study also demonstrated the potential advantage of GLCM analyses to evaluate vascular damage in resource‐challenged settings where contrast enhancement may not be available. This study adds to the repertoire of some recent studies where vascular anatomy has been assessed after liver transplantation. Our study correlates the ultrasound imaging with the molecular changes during ex vivo storage of livers for the first time.…”

Portal Venous Interventions after Liver Transplant

“…In doing so, it provides a qualitative assessment of lesion hemodynamic significance by identifying normal, delayed, diminished, or not detectable liver parenchymal perfusion. 1,20,21 Evaluating PVS with cross-sectional studies, such as contrast enhanced computed tomography (CT), or magnetic resonance imaging (MRI), is limited, as these exams are typically not dynamic (►Fig. 1D).…”

“…39 In challenging settings, CEUS is employed with high diagnostic accuracy for PVT (97--100%). 21,38,40 Rennert et al demonstrated the diagnostic validity of CEUS to be comparable to magnetic resonance angiography (MRA) and computed tomography angiography (CTA), when employed at experienced centers. 21…”

Meta-analysis of the diagnostic value of contrast-enhanced ultrasound for the detection of vascular complications after liver transplantation

“…Relevant data extracted from all 13 studies are summarized in table 1 (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Only two studies involved more than 100 cases for CEUS evaluation.…”