Identification of Drugs Taken in Overdose Cases

Abstract

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Rapid dissolution technique for lead alloys

“…The second method, assuming a molecular ion can be observed or deduced, is to scan a list of organic compounds of the same molecular weight for compounds which might be expected to produce a similar cracking pattern, and to have other appropriate properties. Because the laboratory is biochemically oriented and often assists in overdose cases (2), the Merck Index (3) is a useful source of relevant compounds. Another index published by the Chemical Rubber Co. also contains a molecular weight index for all compounds it contains (4).…”

“…Small sample sizes are frequently encountered; therefore, accurate and sensitive techniques are necessary. Atomic absorption spectrophotometry has been shown to be a valuable tool for the analysis of these alloys (1,2). Sample dissolution, however, remains a problem because of the chemical nature of the main constituents, tin and lead.…”

Plasticizers in Blood-Real or Artifactual?

“…During our recent work on the identification of drugs involved in overdose cases (1,2), we have had occasion to investigate the constituents found in blood, urine, and gastric juices by combined GC-mass spectrometry. In a surprisingly large number of cases, we have observed, in addition to any drugs present, one or more peaks corresponding to phthalate esters (PAEs).…”