Identification of Drug Candidates for Breast Cancer Therapy Through Scaffold Repurposing: A Brief Review

Abstract

: Conventional drug discovery is a time overwhelming and expensive expedition with super less clinical preference achievement proportion intended for breast cancer therapy. Even if numerous novel approaches to the conformation of drugs have been introduced for breast cancer therapy, they have up till now to be implemented in clinical practice. This tempting strategy, facilitate a remarkable chance to take the entire benefit of existing drugs. Despite drug repurposing significantly decrease the investigational period and cost, it has got many objections and issues. Scaffold repurposing is the approach that procures a novel significance on the decrepit motto of “to commencement with a pristine drug” Hence, ourselves move into a probable and nearer approach, the exploitation of scaffolds originally developed for other purposes as well anti-tumour activity. In this review, we summarize the different drugs and scaffolds used in breast cancer therapy.

A Case Report on Malignant Rhabdoid Round Cell Tumor in Pelvis

“…Classification of renal pelvic tumors as following: It includes four grade: Grade I includes papillary with normal mucosa (thickness and morphology), grade II includes papillary with minimal pleomorphisim, mitosis, giant cells, and invasion, grade III includes flat, transitional cells (plant life) to epidermoid (keratin forming) with significant pleomorphism, mitosis, giant cells and invasion, grade IV extreme pleomorphism or marked undifferentiation. Actinomycin D, vincristine, cisplatin, cyclophosphamide, adiramycin, etopside, [14] are among the chemotherapeutic drugs used to treat rhabdoid tumors, with no clear advantage of one over the other [15].…”