Identification of dopamine- and serotonin-related genes modulated by bisphenol A in the prefrontal cortex of male rats

Castro, Beatriz; Sánchez, Pablo Tercedor; Miranda, Marı́a Isabel; Torres, Juan Antonio Vera; Ortega, Esperanza

doi:10.1016/j.chemosphere.2015.06.061

Cited by 34 publications

(16 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several reports have shown the neurotoxic effects of BPA in a variety of animal models [20,[31][32][33][34][35][36][37]. However, the toxic effects of BPA on fish brain development and related gene expression have rarely been studied.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Wang

Lin

et al. 2019

IJMS

View full text Add to dashboard Cite

Bisphenol A (BPA) is an abundant contaminant found in aquatic environments. While a large number of toxicological studies have investigated the effects of BPA, the potential effects of BPA exposure on fish brain have rarely been studied. To understand how BPA impacts goldfish brains, we performed a transcriptome analysis of goldfish brains that had been exposed to 50 μg L−1 and 0 μg L−1 BPA for 30 days. In the analysis of unigene expression profiles, 327 unigenes were found to be upregulated and 153 unigenes were found to be downregulated in the BPA exposure group compared to the control group. Dopaminergic signaling pathway-related genes were significantly downregulated in the BPA exposure group. Furthermore, we found that serum dopamine concentrations decreased and TUNEL (terminal deoxynucleotidyl transferase 2-deoxyuridine, 5-triphosphate nick end labeling) staining was present in dopamine neurons enriched regions in the brain after BPA exposure, suggesting that BPA may disrupt dopaminergic processes. A KEGG analysis revealed that genes involved in the fluid shear stress and atherosclerosis pathway were highly significantly enriched. In addition, the qRT-PCR results for fluid shear stress and atherosclerosis pathway-related genes and the vascular histology of the brain showed that BPA exposure could damage blood vessels and induce brain atherosclerosis. The results of this work provide insights into the biological effects of BPA on dopamine synthesis and blood vessels in goldfish brain and could lay a foundation for future BPA neurotoxicity studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Wang

Lin

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…Our previous findings indicated that adult exposure to BPA decreases the expression of 5α-R isozymes type 1 and type 2 in the prostate of rats (Castro et al, 2013a). In contrast, BPA failed to modify 5α-R expression in the prefrontal cortex (PFC) of adult (Castro et al, 2013b) or juvenile (Castro et al, 2015) male rats. Besides dihydrotestosterone (DHT) synthesis, 5α-R is the rate-limiting enzyme in the biosynthesis of 3α,5α-reduced neurosteroids (3α,5α-NS), such as allopregnanolone (AlloP).…”

Section: Introductionmentioning

confidence: 85%

Bisphenol A, bisphenol F and bisphenol S affect differently 5α-reductase expression and dopamine–serotonin systems in the prefrontal cortex of juvenile female rats

Castro

Sánchez

Torres

et al. 2015

Environmental Research

Self Cite

103

View full text Add to dashboard Cite

“…This study also showed similar findings with BPA. An earlier study by this same group also suggested that BPA could alter such transcripts in this brain region [77]. Other rodent studies with rodents and non-human primates suggest that BPA can disrupt the dopamine system in other brain regions, such as the corpus striatum, mid-brain region, limbic forebrain, and isolated neurons [75; 78; 79; 80; 81; 82; 83].…”

Section: Neuroendocrine Disruption Due To Exposure Of Rodent Models Tmentioning

confidence: 96%

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Rosenfeld

2017

Frontiers in Neuroendocrinology

View full text Add to dashboard Cite

Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF). However, it is not clear whether these other compounds are safer in terms of inducing less endocrine disrupting effects in animals and humans who are now increasingly coming into contact with these BPA-substitutes. In the past few years, several animal studies have shown exposure to these other bisphenols induce similar neurobehavioral disruption as BPA. We will explore in this review article the current studies suggesting these other bisphenols result in neuroendocrine disruptions that may be estrogen receptor-dependent. Current work may aide in designing future studies to test further whether these BPA-substitutes can act as neuroendocrine disruptors.

show abstract

Identification of dopamine- and serotonin-related genes modulated by bisphenol A in the prefrontal cortex of male rats

Cited by 34 publications

References 41 publications

Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

Bisphenol A, bisphenol F and bisphenol S affect differently 5α-reductase expression and dopamine–serotonin systems in the prefrontal cortex of juvenile female rats

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues

Contact Info

Product

Resources

About