Identification of dominant anti-glycan IgE responses in school children by glycan microarray

Amoah, Abena S.; Asuming-Brempong, Elias K.; Obeng, Benedicta B.; Versteeg, Serge A.; Larbi, Irene A.; Aryeetey, Yvonne; Platts-Mills, Thomas A.E.; Mari, Adriano; Brzezicka, Katarzyna; Gyan, Ben; Mutocheluh, Mohamed; Boakye, Daniel; Reichardt, Niels‐Christian; Ree, Ronald van; Hokke, Cornelis H.; Diepen, Angela van; Yazdanbakhsh, Maria

doi:10.1016/j.jaci.2017.09.040

Cited by 18 publications

(30 citation statements)

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“…A history of tick‐bite exposure has been shown to be strongly correlated with high levels of IgE to α‐gal . Specific tick species worldwide have been implicated in the induction of IgE to α‐gal such as the lone star tick ( Amblyomma americanum ) in the Southeastern United States, the castor bean tick ( Ixodes ricinus ) in Sweden, the Australian paralysis tick ( Ixodes holocyclus ) in Australia and the cattle tick ( Haemaphysalis longicornis ) in Japan . Although no direct link has been made between α‐gal and helminths in Africa, elevated levels of IgE to α‐gal have been seen in individuals from helminth‐endemic areas in Ghana, Kenya and Zimbabwe .…”

Section: Helminths and Allergy‐related Outcomes: Immune Mechanisms Inmentioning

confidence: 99%

“…Specific tick species worldwide have been implicated in the induction of IgE to α‐gal such as the lone star tick ( Amblyomma americanum ) in the Southeastern United States, the castor bean tick ( Ixodes ricinus ) in Sweden, the Australian paralysis tick ( Ixodes holocyclus ) in Australia and the cattle tick ( Haemaphysalis longicornis ) in Japan . Although no direct link has been made between α‐gal and helminths in Africa, elevated levels of IgE to α‐gal have been seen in individuals from helminth‐endemic areas in Ghana, Kenya and Zimbabwe . In Ghana, α‐gal sensitization has been strongly linked to rural residence rather than current helminth infection, but further studies are needed to identify the specific factors associated with rural living that underlie this sensitization.…”

Section: Helminths and Allergy‐related Outcomes: Immune Mechanisms Inmentioning

confidence: 99%

“…In a subset of children in that study, inhibition assays showed that S. haematobium soluble egg antigen and the CCD marker bromelain were strong inhibitors of IgE binding to peanut extract. 33 In a follow-up study that used a synthetic glycan microarray to identify the specific glycan motifs associated with carbohydrate-related IgE crossreactivity, 64 Schistosoma infection was linked to IgE cross-reactivity involving the core xylose glycan motif. 64 Although further investigations are needed to examine how CCD-specific IgE may inhibit allergic effector responses, Doenoff and colleagues have explored the role of IgG antibodies as blocking antibodies.…”

Section: Helminth-induced Ige Cross-reactivitymentioning

confidence: 99%

“…33 In a follow-up study that used a synthetic glycan microarray to identify the specific glycan motifs associated with carbohydrate-related IgE crossreactivity, 64 Schistosoma infection was linked to IgE cross-reactivity involving the core xylose glycan motif. 64 Although further investigations are needed to examine how CCD-specific IgE may inhibit allergic effector responses, Doenoff and colleagues have explored the role of IgG antibodies as blocking antibodies. 65,66 Through in vitro studies, rabbit anti-schistosome IgG was found to cross-react with allergens such as latex 65 and peanut extract.…”

Section: Helminth-induced Ige Cross-reactivitymentioning

confidence: 99%

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Parasites and allergy: Observations from Africa

Mpairwe

Amoah

2018

Parasite Immunology

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Population studies from the African continent have observed a marked increase in the prevalence of allergy-related diseases over the past few decades, but the cause of this rise is not fully understood. The most investigated potential risk factor has been the relationship between exposure to helminths and allergy-related outcomes. Immunologically, parallels exist between responses to helminths and to allergens as both are associated with elevated levels of immunoglobulin E, increased numbers of T helper 2 cells and other immune cells. However, epidemiological studies from the African continent have found inconsistent results. In this review, observations from population studies carried out in Africa over the last decade that focus on the relationship between helminth infections and allergy-related outcomes are examined. How these findings advance our understanding of the complex interactions between helminths and allergies at the population level is also explored as well as some of the underlying immune mechanisms involved. This knowledge is important for better diagnosis, treatment and prevention of allergy-related diseases and has wider global significance.

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Section: Helminths and Allergy‐related Outcomes: Immune Mechanisms Inmentioning

confidence: 99%

Section: Helminths and Allergy‐related Outcomes: Immune Mechanisms Inmentioning

confidence: 99%

Section: Helminth-induced Ige Cross-reactivitymentioning

confidence: 99%

Section: Helminth-induced Ige Cross-reactivitymentioning

confidence: 99%

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Parasites and allergy: Observations from Africa

Mpairwe

Amoah

2018

Parasite Immunology

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“…If, after presentation by the appropriate APC, an AGA recognizes a presented food glycan to be molecularly similar to a non-self (xeno) antigen, the AGA will react and elicit an immune response. CCDs have been observed between environmental and food allergens through high levels of IgE AGA [161]. For example, there are circulating AGA in healthy humans against N-glycolylneuraminic acid (Neu5Gc) and galactose alpha-1,3-galactose (α-gal), glycans present in dairy products and red meats [162].…”

Section: Glycan Reactionsmentioning

confidence: 99%

Blood Type Diets (BTD) and Aging: An Overview

Menapace¹

2019

J Aging Sci

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It has recently been proposed that glycans, being the third alphabet of life, interact intricately with endogenous biomolecules to modulate tolerance, immune and inflammatory responses. Specifically, food glycans could impact health and be a source of inflammation and age-related diseases. These special carbohydrates are present as glycoconjugates (glycoproteins or glycolipids) in and on the surface of all the cells (glycocalyx) of all organisms or are found in free form in biological fluids. Recent advances in glycobiology and glycochemistry have shown how glycans bind with naturally present human proteins (lectins), through protein-carbohydrate interactions (or PCI), but also how oligosaccharides can interact with other glycans, present throughout the human body (through carbohydrate-carbohydrate interactions, or CCI). Oligosaccharides present in food sources, which go beyond the definition of normal fibers, once ingested are then either absorbed in the bloodstream, where they are recognized by the immune system, or interact with the surface of GI epithelial cells, thus generating appropriate biochemical cascades that induce a tolerance or immune/inflammatory response. Because the ABO epitopes have been encountered on all human cells, not just erythrocytes and based on the different biotypology (A, AB, B, and O) impose morphic changes in the distribution of the glycans on the glycocalyx (lipid rafts and clustered saccharide patches), their CCI with food and microbe glycans will be different, thus, eliciting contrasting responses. This can explain the epidemiological data for blood type diets (BTD). Through continuous consumption of the wrong types of glycans, processes of chronic inflammation could be initiated and progress to accelerated aging. Four basic modes of action have been identified showing how glycans can trigger inflamm-aging. Since glycobiology is a young science, further studies with newer technologies are warranted for advancement in this field.

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Glycosphingolipids in human parasites

Cummings

2023

FEBS Open Bio

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Glycosphingolipids (GSLs) are comprised of glycans (oligosaccharides) linked to a lipid containing a sphingosine moiety. They are major membrane components in cells of most animals, and importantly, they also occur in parasitic protozoans and worms that infect people. While the endogenous functions of the GSLs in most parasites are elusive, many of these GSLs are recognized by antibodies in infected human and animal hosts, and thus, their structures, biosynthesis, and functions are of great interest. Such knowledge of GSLs could lead to new drugs and diagnostics for treating infections, as well as novel vaccine strategies. The diversity of GSLs recently identified in such infectious organisms and aspects of their immune recognition are major topics of this review. It is not intended to be exhaustive but to highlight aspects of GSL glycans in human parasites.

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Identification of dominant anti-glycan IgE responses in school children by glycan microarray

Abstract: Disclosure of potential conflict of interest: R. Newton's institution received a grant from AstraZeneca for other works and he personally received travel expenses from AstraZeneca. The rest of the authors declare that they have no relevant conflicts of interest.

Cited by 18 publications

References 8 publications

Parasites and allergy: Observations from Africa

Parasites and allergy: Observations from Africa

Blood Type Diets (BTD) and Aging: An Overview

Glycosphingolipids in human parasites

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