Identification of DNA copy-number aberrations by array-comparative genomic hybridization in patients with schizophrenia

Moon, Ho Jin; Yim, Sung-Vin; Lee, Woon Kyu; Jeon, Young‐Woo; Kim, Young Hoon; Ko, Young Jin; Lee, Kwang‐Soo; Lee, Kweon-Haeng; Han, Sang-Ick; Rha, Hyoung Kyun

doi:10.1016/j.bbrc.2006.03.156

Cited by 43 publications

(58 citation statements)

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“…16 CNVs in specific chromosomal regions have been reported that are appreciably increased in samples of schizophrenia, particularly in early age of onset. 8,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Copy number variants that are shared with schizophrenia but not with bipolar disorder have been found in epilepsy. 29,[34][35][36][37] CNVs have also been found to be strongly associated with autism, attention deficit hyperactivity disorder and learning disability.…”

Section: Introductionmentioning

confidence: 99%

Analysis of genetic deletions and duplications in the University College London bipolar disorder case control sample

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Analysis of genetic deletions and duplications in the University College London bipolar disorder case control sample

et al. 2011

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“…Thus, contribution of sex chromosomal abnormalities found in this study is less likely. Four microarray CGH studies of schizophrenia were reported: 1,440 BAC microarray for 30 patients, 2,460 BAC microarray for 35 patients, a tiling-path microarray consisting of *36,000 BACs for 93 patients, and highresolution microarrays (85,000-2,100,000 oligos) for 150 patients (Kirov et al 2008;Moon et al 2006;Walsh et al 2008;Wilson et al 2006). We could not replicate any similar abnormalities, though microarray platforms were all different in terms of clones and genome coverage.…”

Section: Resultsmentioning

confidence: 99%

Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia

et al. 2008

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Schizophrenia is a common psychiatric disorder with a strong genetic contribution. Disease-associated chromosomal abnormalities in this condition may provide important clues, such as DISC1. In this study, 59 schizophrenia patients were analyzed by microarray comparative genomic hybridization (CGH) using custom bacterial artificial chromosome (BAC) microarray (4,219 BACs with 0.7-Mb resolution). Chromosomal abnormalities were found in six patients (10%): 46,XY,der(13)t(12;13)(p12.1; p11).ish del(5)(p11p12); 46,XY, ish del(17)(p12p12); 46,XX.ish dup(11)(p13p13); and 46,X,idic(Y)(q11.2); and in two cases, mos 45,X/46XX. Autosomal abnormalities in three cases are likely to be pathogenic, and sex chromosome abnormalities in three follow previous findings. It is noteworthy that 10% of patients with schizophrenia have (sub)microscopic chromosomal abnormalities, indicating that genome-wide copy number survey should be considered in genetic studies of schizophrenia.

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“…The chromosome 15q15 region has been reported to be a susceptibility locus on schizophrenia [33] [34] [35], and clinical symptoms of schizophrenia such as periodic catatonia [33] [34].…”

Section: Synaptic Regulation and Schizophreniamentioning

confidence: 99%

“…However, given the involvement of astrocytes in the pathogenesis of schizophrenia, and the role of THBS1 in synaptic alteration, it is speculated that THBS1 may be a candidate gene involved in schizophrenia [33] [34] [35]. The finding here of PDLIM5 as a potential marker of schizophrenia subtype expands the role of synaptogenesis in neuropsychiatric disorders more generally [36] [37].…”

Section: Synaptic Regulation and Schizophreniamentioning

confidence: 99%

Are There Schizophrenia Genetic Markers and Mutations? A Systematic Review and Meta-Analyses

Cardoso¹,

Nascimento²,

Bernardo³

et al. 2017

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Background: Schizophrenia is a severe psychiatric disorder with a complex genetic factor determining its disease onset. Nevertheless, it is not clear in this mental disorder. Objective: To conduct a systematic review of articles regarding the genetic markers and mutations in schizophrenia. Methods: A systematic review of articles on genetic markers and mutations in schizophrenia, published from January 1, 2011, to September 7, 2015, on SCOPUS database was carried out. Search terms were "Genetic markers", "Mutation", and "Schizophrenia". Results: Of the 527 retrieved studies, 31 met the eligibility criteria. Genetic polymorphism, Immune-associated genes, TCF4 and ZNF804A association with microRNA, Neuregulin gene, Chromosome 13q32 and 11p15.4, genes involved in glutamatergic via schizophrenia and brain structure, appeared to be associated with the origin of schizophrenia. Conclusion: Some studies show genes involved in several pathways leading to the disease pathogenesis such as that one related with the dopaminergic and immune system, or rare alleles. Some genes present no involvement in the etiology of this mental disorder. These findings clarify the genetic complexity of schizophrenia and affirm that together, the genes have an overall effect greater than the sum of the individual effect of each gene. KeywordsSchizophrenia, Genetic Markers, Mutations, Systematic Review How to cite this paper: Cardoso, M.A.B.S., do Nascimento, T

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Identification of DNA copy-number aberrations by array-comparative genomic hybridization in patients with schizophrenia

Cited by 43 publications

References 36 publications

Analysis of genetic deletions and duplications in the University College London bipolar disorder case control sample

Analysis of genetic deletions and duplications in the University College London bipolar disorder case control sample

Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia

Are There Schizophrenia Genetic Markers and Mutations? A Systematic Review and Meta-Analyses

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