Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing Component of the Leaves of Cinnamomum camphora

Abstract

Immunoglobulin E (IgE) plays an important role in allergic diseases. In this study, we found that a methanol extract of leaves of the camphor tree Cinnamomum camphora (C. camphora) reduced the amount of IgE secreted by human myeloma U266 cells. When the methanol extract was fractionated by extraction with organic solvents, the ethyl acetate fraction showed the highest activity. The fraction was further separated into several subfractions by preparative TLC. We identified the component of one of the active subfractions as dimethylmatairesinol. Authentic dimethylmatairesinol exhibited similar activity. Thus, the extract of C. camphora and its components including dimethylmatairesinol have potential as an anti-allergic agent.

Chemical Constituents and Insecticidal Activities of the Essential Oil ofCinnamomum camphoraLeaves againstLasioderma serricorne

“…Cinnamomum camphora (L.) Presl (family: Lauraceae) is a Chinese medicinal plant widespread in China and has long been prescribed in traditional medicine for treatment of inflammation-related diseases, such as rheumatism, sprains, bronchitis, and muscle pains [7]. Pharmacological studies have revealed that the plant possesses a wide range of therapeutic activities, including anthelmintic [8], sperm viability effect [9], antibacterial [10], antiallergic [11], and antiinflammatory [12]. C. camphora is a well-known chemotype; on distillation, the wood from different groups of trees may yield camphor, linalool, safrole, or cineole as the major chemical.…”

Plausible role of Arq Ajīb in combating COVID-19: A multi-faceted review

“…Kafoor (C. camphora) has been reported to exhibit several biological activities such as antiviral 43 , antimicrobial 43,44 , insecticidal 45 , antitussive 46,47 , antiinflammatory and antioxidant 48 , anti-allergic 49 , antimutagenic and anticancer 43 activities.…”

“…The combined effects of phytocompounds present in the formulation may yield a synergistic effect with potentially enhanced biological activities. Moreover, the formulation may also prove beneficial in providing symptomatic relief in patients affected with COVID-19, as the formulation ingredients and their phytocompounds have been reported to exhibit antiallergic, antitussive and bronchodilatory activities 46,47,49,[61][62][63] . Hence, it is rational to state that the formulation may prove effective in augmenting the immune status, alleviating inflammatory responses and suppressing the virulence of SARS-CoV-2.…”

“…as the main component of one of the active subfractions. The study suggested C. camphora extract and its component including dimethylmatairesinol as a potent anti-allergic agent49 .…”

Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (−)- and (+)-niranthin against hepatitis B and influenza viruses

“…Lignans are attracting considerable attention due to their widespread distribution in plants and their varied bioactivity. 1–5 For example, matairesinol, 2 dimethylmatairesinol, 3 yatein, 4 and niranthin 5 are found in nature and exhibit e.g. , cytotoxicity, 2 b , d ,3 b ,4 b anti-bacterial, 2 c anti-allergic, 3 c anti-viral, 4 d ,5 b , e anti-leishmanial, 5 d and strong insect-feeding-deterrent activity.…”