Identification of Differently Metylated Genes  Potentially Related to Human Atherosclerosis

Nazarenko, M. S.; Марков, А. В.; Королева, Ю. А.; Слепцов, А. А.; Казанцев, А. Н.; Барбараш, О. Л.; Puzyrev, V P

doi:10.15829/1560-4071-2017-10-42-48

Cited by 14 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Systemic risk factors for the development of restenosis affect CEA outcomes regardless of intervention type [32][33][34][35][36] . Most of them are modifiable, yet it has been shown that genetic background also affects the long-term outcomes [37][38][39][40][41] . Additional supervision of high-risk patients might permit early detection of ICA restenosis and timely repeated revascularization, preventing cerebrovascular accidents and death [37][38][39][40][41] .…”

Section: Discussionmentioning

confidence: 99%

Long-term outcomes of eversion and conventional carotid endarterectomy: A multicenter clinical trial

et al. 2022

View full text Add to dashboard Cite

Aim To compare the long-term results of eversion (ECEA) and conventional carotid endarterectomy (CCEA). Methods We designed a retrospective, multicenter study which included 25,106 patients who underwent ECEA ( n = 18,362) or CCEA ( n = 6744). The duration of follow-up was 124.7 ± 53.8 months. Results In the postoperative period, none of the interventions showed clear benefits reducing the frequency of complications: fatal outcome (ECEA: 0.19%, n = 36; CCEA: 0.17%, n = 12; OR = 1.1, 95% CI = 0.57–2.11, p = 0.89), myocardial infarction (ECEA: 0.15%, n = 28; CCEA: 0.13%, n = 9; p = 0.87; OR = 1.14; 95% CI = 0.53–2.42); acute cerebrovascular accident (CVA) (Group I: 0.33%, n = 62; Group II: 0.4%, n = 27; p = 0.53; OR = 0.84; 95% CI = 0, 53–1.32); bleeding with acute haematoma appearance in the area of intervention (Group I: 0.39%, n = 73; Group II: 0.41%, n = 28; p = 0.93; OR = 0.95; 95% CI = 0, 61–1.48); internal carotid artery (ICA) thrombosis (Group I: 0.05%, n = 11; Group II: 0.07%, n = 5; OR = 0.80, 95% CI = 0.28–2.32, p = 0.90). During the long-term follow-up, ECEA was associated with lower frequency of fatal outcome (ECEA: 2.7%, n = 492; CCEA: 9.1%, n = 616; OR = 0.27; 95% CI = 0.24–0.3, p < 0.0001), cerebrovascular death (ECEA: 1.0%, n = 180; CCEA: 5.5%, n = 371; OR = 0.17, 95% CI = 0.14–0.21, p < 0.0001), non-fatal ischaemic stroke (ECEA: 0.62%, n = 114; CCEA: 7.0%, n = 472; OR = 0.08; 95% CI = 0.06–0.1, p < 0.0001); repeated revascularization because of >60% restenosis (ECEA: 1.6%, n = 296; CCEA: 12.6%, n = 851; OR = 0.11, 95% CI = 0.09–0.12, p < 0.0001), and combined endpoint (ECEA: 2.2%, n = 397; CCEA: 13.2%, n = 888; OR = 0.14; 95% CI = 0.12–1.16, p < 0.0001). Conclusion ECEA is beneficial over CCEA in a long term.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-term outcomes of eversion and conventional carotid endarterectomy: A multicenter clinical trial

et al. 2022

View full text Add to dashboard Cite

show abstract

“…При анализе отдаленных результатов КЭЭ у больных с СД 2 авторы приводят данные, доказывающие, что в этой когорте пациентов больше частота развития рестеноза ВСА, ОНМК, ИМ, летального исхода [31][32][33]. Настоящие процессы, безусловно, являются мультитаргетными и включают в себя наследственность, образ жизни, последствия метаболического синдрома [34,35]. Тем не менее дисфункция эндотелия, развивающаяся на фоне СД 2 типа, вносит существенный вклад в развитие макро-и микроангиопатии, а также атеросклероза различной локализации [36][37][38][39].…”

Section: результатыunclassified

Long-term outcomes of combined coronary bypass surgery and carotid endarterectomy in patients with type 2 diabetes

IuV

Ustinova

et al. 2022

Russ J Cardiol

View full text Add to dashboard Cite

At present, there are no studies on the analysis of the incidence of complications in patients with concomitant lesions of the coronary and internal carotid arteries (ICA) after combined operation of carotid endarterectomy (CE) and coronary artery bypass grafting (CABG) against the background of type 2 diabetes (T2D). However, there is no doubt that this condition can be a predictor of cardiovascular and wound complications during in-hospital and long-term postoperative periods.Aim. To study in-hospital and long-term outcomes of combined CABG+CE in patients with and without type 2 diabetes.Material and methods. This multicenter retrospective study for the period from January 2015 to December 2019 included 653 patients with concomitant atherosclerotic lesions of ICA and coronary arteries, who underwent combined CE+CABG. Depending on presence of type 2 diabetes, 2 groups were formed: group 1 (n=183) — patients with type 2 diabetes; group 2 (n=471) — patients without type 2 diabetes. The duration of postoperative follow-up was 37,8±14,9 months.Results. During hospitalization, significant differences in the incidence of death (group 1 =1,1%; group 2 =1,0%; p=0,97), myocardial infarction (MI) (group 1 =1,1%; group 2 =0,8%; p=0,76), bleeding events (group 1 =1,1%; group 2 =0,8%; p=0,76) were not detected. However, stroke (group 1 =3,8%; group 2 =0,4%; p=0,0008), sternal wound infection and mediastinitis (group 1 =3,3%; group 2 =0,2%; p=0,0006) were significantly more often developed in patients with type 2 diabetes.In the long-term follow-up period, death (group 1 =6,6%; group 2 =1,1%; p<0,0001), MI (group 1 =4,9%; group 2 =0,8%; p=0,0008), stroke (group 1 =7,7%; group 2 =1,5%; p<0,0001), ICA restenosis (group 1 =8,8%; group 2 =1,6%; p<0,0001), repeated emergency myocardial revascularization (group 1 =7,2%; group 2 =1,5%; p=0,0002), repeated emergency cerebral revascularization (group 1 =8,8%; group 2 =1,6%; p<0,0001) were significantly more often recorded in patients with type 2 diabetes.Kaplan-Meier curve analysis and its comparison using the log rank test revealed that the death, MI, and stroke were also significantly more often observed in patients with type 2 diabetes (p=0,0007, p=0,003, p<0,0001, respectively).Conclusion. Patients with type 2 diabetes who are referred for combined CE+CABG are at an increased risk of stroke, sternal wound infection and mediastinitis in the in-hospital postoperative period, as well as all adverse cardiovascular events in the long-term follow-up period.

show abstract

“…[28]. Однако в исследованиях Назаренко М. С. и др., посвященных генетическим аспектам этого процесса, отмечено, что у больных с рестенозом ВСА после КЭЭ имеется структурная вариабельность локуса APOBEC3A-APOBEC3B, соматический мозаицизм гена GBP3 и другие отличия, способные вызвать позднюю потерю просвета сосуда [29][30][31]. Так может быть техника операции здесь ни при чём, и рестеноз ВСА развивается там, где это заложено в ДНК?…”

Section: обзоры литературыunclassified

Methods of carotid endarterectomy

et al. 2021

View full text Add to dashboard Cite

This literature review is devoted to various carotid endarterectomy (CE) methods that exist today in Russia. The pros and cons of conventional and eversion technique of the operation are given. It is indicated that the former is associated with higher long-term rate of restenosis, aneurysm and patch infection. The second is associated with higher prevalence of intraoperative internal carotid artery (ICA) thrombosis due to intimal detachment distal to endarterectomy area. The following CE methods for patients with prolonged ICA involvement are described: neo bifurcation formation, autoarterial reconstruction, ICA autotransplantation, plastic using an occipital artery flap. The methods of CE with carotid body saving have been demonstrated: 1. Swallow tail type patch repair proposed by R.I. Izhbuldin; 2. S-shaped arteriotomy proposed by K. A. Antsupov; 3. Two types of operations proposed by R. А. Vinogradov; 4. Сutting off the ICA with sections of common and external carotid artery proposed by A. N. Kazantsev; 5. Glomus-saving ICA autotransplantation in patients with prolonged atherosclerotic involvement. The role of ICA transposition over the hypoglossal nerve in eversion CE is presented. The glomus-saving CE with ICA transposition, called Chik-Chirik CE, is described. Conclusions are drawn on the need to demonstrate all CE types in the novel Russian guidelines for the management of patients with of head and neck arterial diseases.

show abstract

Identification of Differently Metylated Genes Potentially Related to Human Atherosclerosis

Cited by 14 publications

References 25 publications

Long-term outcomes of eversion and conventional carotid endarterectomy: A multicenter clinical trial

Long-term outcomes of eversion and conventional carotid endarterectomy: A multicenter clinical trial

Long-term outcomes of combined coronary bypass surgery and carotid endarterectomy in patients with type 2 diabetes

Methods of carotid endarterectomy

Contact Info

Product

Resources

About