Identification of Differentially Expressed Proteins in Curcumin-Treated Prostate Cancer Cell Lines

Teiten, Marie-Hélène; Gaigneaux, Anthoula; Chateauvieux, Sébastien; Billing, Anja M.; Planchon, Sébastien; Fack, Fred; Renaut, Jenny; Mack, Fabienne; Dicato, Mario; Diederich, Marc

doi:10.1089/omi.2011.0136

Cited by 43 publications

(27 citation statements)

References 55 publications

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“…Curcumin also upregulated the tumor suppressor miR‐22 in human Y79 retinoblastoma cells . The levels of several proteins expressed in curcumin‐treated prostate cancer cell lines correlated with miR‐141 , miR‐152 and miR‐183 expression . Curcumin decreased the expression of WT1 by upregulating miR‐15a and miR‐16‐1 in leukemic cells .…”

Section: Polyphenol‐dependent Micro‐rna Expressionmentioning

confidence: 95%

“…49 The levels of several proteins expressed in curcumin-treated prostate cancer cell lines correlated with miR-141, miR-152 and miR-183 expression. 50 Curcumin decreased the expression of WT1 by upregulating miR-15a and miR-16-1 in leukemic cells. 51 It also induced cell death in esophageal cancer cells by modulating Notch signaling, by downregulating the expression of Notch-1-targeting miRNAs miR-21 and miR-34a, and by upregulating the tumor suppressor miRNA let-7a.…”

Section: Effects Of Curcuminmentioning

confidence: 99%

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Effects of dietary phytophenols on the expression of microRNAs involved in mammalian cell homeostasis

2013

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Besides synthesizing nutritive substances (proteins, fats and carbohydrates) for energy and growth, plants produce numerous non-energetic so-called secondary metabolites (mainly polyphenols) that allow them to protect themselves against infections and other types of hostile environments. Interestingly, these polyphenols often provide cells with valuable bioactive properties for the maintenance of their functions and homeostasis (signaling, gene regulation, protection against acquired or infectious diseases, etc.) both in humans and animals. Namely, from a nutritional point of view, and based on epidemiological data, it is now well accepted that the regular consumption of green vegetables, fruits and fibers has protective effects against the onset of cancer as well as of inflammatory, neurodegenerative, metabolic and cardiovascular diseases, and consequently increases the overall longevity. In particular, grapevine plants produce large amounts of a wide variety of polyphenols. The most prominent of those-resveratrol-has been shown to impair or delay cardiovascular alterations, cancer, inflammation, aging, etc. Until recently, the molecular bases of the pleiotropic effects of resveratrol remained largely unclear despite numerous studies on a variety of signaling pathways and the transcriptional networks that they control. However, it has been recently proposed that the protective properties of resveratrol may arise from its modulation of small non-coding regulatory RNAs, namely microRNAs. The aim of this review is to present up-to-date data on the control of microRNA expression by dietary phytophenols in different types of human cells, and their impact on cell differentiation, cancer development and the regulation of the inflammatory response.

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Section: Polyphenol‐dependent Micro‐rna Expressionmentioning

confidence: 95%

Section: Effects Of Curcuminmentioning

confidence: 99%

Effects of dietary phytophenols on the expression of microRNAs involved in mammalian cell homeostasis

2013

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“…Further NPM1 resulted overexpressed in PCa 143. NPM1 is an abundant multifunctional protein which is present in high quantities in the granular region of nucleoli 144.…”

Section: Androgen Receptor Signalingmentioning

confidence: 99%

Molecular signaling involving intrinsically disordered proteins in prostate cancer

et al. 2016

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Investigations on cellular protein interaction networks (PINs) reveal that proteins that constitute hubs in a PIN are notably enriched in Intrinsically Disordered Proteins (IDPs) compared to proteins that constitute edges, highlighting the role of IDPs in signaling pathways. Most IDPs rapidly undergo disorder-to-order transitions upon binding to their biological targets to perform their function. Conformational dynamics enables IDPs to be versatile and to interact with a broad range of interactors under normal physiological conditions where their expression is tightly modulated. IDPs are involved in many cellular processes such as cellular signaling, transcriptional regulation, and splicing; thus, their high-specificity/low-affinity interactions play crucial roles in many human diseases including cancer. Prostate cancer (PCa) is one of the leading causes of cancer-related mortality in men worldwide. Therefore, identifying molecular mechanisms of the oncogenic signaling pathways that are involved in prostate carcinogenesis is crucial. In this review, we focus on the aspects of cellular pathways leading to PCa in which IDPs exert a primary role.

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“…Curcumin has the ability to inhibit cell growth and induce apoptosis in both androgen-dependent and androgenindependent prostate cancer cell lines acting through the regulation of apoptosis relative signaling (Hilchie et al, 2010;Wei et al, 2013) and other crucial proteins (Teiten et al, 2012;Horie, 2012;Kang et al, 2013). By targeting the inflammatory cytokines CXCL-1 and -2, curcumin also inhibited prostate cancer metastasis in vivo (Killian et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Curcumin Inhibits Expression of Inhibitor of DNA Binding 1 in PC3 Cells and Xenografts

Tao²,

Zhao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Inhibitor of DNA binding 1 (Id1) plays an important role in genesis and metastatic progression of prostate cancer. We previously reported that down regulation of Id1 by small interfering RNA could inhibit the proliferation of PC3 cells and growth of its xenografted tumors. Curcumin, the active ingredient of turmeric, has shown anti-cancer properties via modulation of a number of different molecular regulators. Here we investigated whether Id1 might be involved in the anti-cancer effects of curcumin in vivo and in vitro. We firstly confirmed that curcumin inhibited cell viability in a dose-dependent fashion, and induced apoptosis in PC3 cells, associated with significant decrease in the mRNA and protein expression of Id1. Similar effects of curcumin were observed in tumors of the PC3 xenografted mouse model with introperitoneal injection of curcumin once a day for one month. Tumor growth in mice was obviously suppressed by curcumin during the period of 24 to 30 days. Both mRNA and protein levels of Id1 were significantly down-regulated in xenografted tumors. Our findings point to a novel molecular pathway for curcumin anti-cancer effects. Curcumin may be used as an Id1 inhibitor to modulate Id1 expression.

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Identification of Differentially Expressed Proteins in Curcumin-Treated Prostate Cancer Cell Lines

Cited by 43 publications

References 55 publications

Effects of dietary phytophenols on the expression of microRNAs involved in mammalian cell homeostasis

Effects of dietary phytophenols on the expression of microRNAs involved in mammalian cell homeostasis

Molecular signaling involving intrinsically disordered proteins in prostate cancer

Curcumin Inhibits Expression of Inhibitor of DNA Binding 1 in PC3 Cells and Xenografts

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