Identification of Dialister pneumosintes in healthy and chronic periodontitis patients with Type 2 diabetes mellitus and its correlation with the red complex bacteria

Oswal, Pratima; Katti, Sandeep; Joshi, Vinayak; Shaikh, Hawaabi Faqeer Mohd

doi:10.4103/jid.jid_4_19

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Interestingly, many of the species that were deemed both significantly ‘important’ and elevated in relative abundance within CRC are also found in the oral microbiome and noted to be associated with oral diseases (periodontitis, periapical lesions, root canal infections, oral cancers, etc.) which have been associated with increased risks of CRC [ 36 – 45 ]. Subsequently, we utilized the expanded Human Oral Microbe Database (eHOMD) [ 46 ] to classify all oral species within our samples and found a significant increase in the total oral microbe population richness existing within the CRC-associated gut microbiome in comparison to that of the Healthy group (MWU: pvalue = 6.51e-05) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Bacterial community structure alterations within the colorectal cancer gut microbiome

2021

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Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The human gut microbiome has become an active area of research for understanding the initiation, progression, and treatment of colorectal cancer. Despite multiple studies having found significant alterations in the carriage of specific bacteria within the gut microbiome of colorectal cancer patients, no single bacterium has been unequivocally connected to all cases. Whether alterations in species carriages are the cause or outcome of cancer formation is still unclear, but what is clear is that focus should be placed on understanding changes to the bacterial community structure within the cancer-associated gut microbiome. Results By applying a novel set of analyses on 252 previously published whole-genome shotgun sequenced fecal samples from healthy and late-stage colorectal cancer subjects, we identify taxonomic, functional, and structural changes within the cancer-associated human gut microbiome. Bacterial association networks constructed from these data exhibited widespread differences in the underlying bacterial community structure between healthy and colorectal cancer associated gut microbiomes. Within the cancer-associated ecosystem, bacterial species were found to form associations with other species that are taxonomically and functionally dissimilar to themselves, as well as form modules functionally geared towards potential changes in the tumor-associated ecosystem. Bacterial community profiling of these samples revealed a significant increase in species diversity within the cancer-associated gut microbiome, and an elevated relative abundance of species classified as originating from the oral microbiome including, but not limited to, Fusobacterium nucleatum, Peptostreptococcus stomatis, Gemella morbillorum, and Parvimonas micra. Differential abundance analyses of community functional capabilities revealed an elevation in functions linked to virulence factors and peptide degradation, and a reduction in functions involved in amino-acid biosynthesis within the colorectal cancer gut microbiome. Conclusions We utilize whole-genome shotgun sequenced fecal samples provided from a large cohort of late-stage colorectal cancer and healthy subjects to identify a number of potentially important taxonomic, functional, and structural alterations occurring within the colorectal cancer associated gut microbiome. Our analyses indicate that the cancer-associated ecosystem influences bacterial partner selection in the native microbiota, and we highlight specific oral bacteria and their associations as potentially relevant towards aiding tumor progression.

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Section: Resultsmentioning

confidence: 99%

Bacterial community structure alterations within the colorectal cancer gut microbiome

2021

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“…Somewhat unexpected associations also occurred exclusively in the matched control networks between Gemella and Granulicatella (occurs in 72 of the 100 matched control networks), and between Rothia and Granulicatella (55 of the 100 control networks), as Granulicatella has also been associated with CF [ 73 , 156 , 157 ] and caries due to its acidogenic nature [ 158 ]. The significant associations seen exclusively in our matched control networks involving Ralstonia and Variovorax [ 159–162 ], Atopobium [ 163 , 164 ], Bradyrhizobium [ 165 ], Hyphomicrobium [ 166 ], Actinomyces [ 167 ], Stomatobaculum [ 168 ], Rothia [ 102 , 163 , 164 ], Clostridiales Family_XIII [ 101 ], Parvimonas [ 97 , 101 , 169 ], Treponema [ 97 , 101 ], Filifactor [ 101 , 170 , 171 ], and Dialister [ 172 , 173 ], all relate to organisms implicated in periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Citizen-science based study of the oral microbiome in Cystic fibrosis and matched controls reveals major differences in diversity and abundance of bacterial and fungal species

Willis

Saus

Iraola-Guzmán

et al. 2021

Journal of Oral Microbiology

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Effectiveness of ozone in the management of chronic periodontitis: A clinico-microbiological study

Musalaiah,

Kumar,

Prabhudev

et al. 2024

Journal of Dr. YSR University of Health Sciences

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Aim: To evaluate the efficacy of ozonated water with NSPT compared with scaling and root planing (SRP) alone in treating chronic periodontitis. Settings and Design: The current study is a double-masked, randomized clinical trial. Methods and Material: A total of 30 patients aged 25 to 55 years were divided randomly into two groups having probing pocket depths of ≥ 5 mm. Full mouth SRP were performed in group 1 followed by additional sub-gingival irrigation of ozonated water in group 2. Assessment of plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment levels (CAL) was performed at baseline and six months. Microbiologic assessment with real-time polymerase chain reaction was performed for Dialister pneumosintes and Micromonas micros by collecting plaque samples. Statistical Analysis Used: The data were subjected to statistical analysis with IBM SPSS Software version 21. The results were presented under the headings of various parameters considered for this study. Results: The results revealed that there was a reduction in PI, GI, PD, CAL, and microbiologic parameters in both groups following SRP; the results were more significant in group 2 treated by sub-gingival irrigation with ozonated water, when compared with SRP alone in group 1. Also, it was noted that there was a statistically significant reduction of M. micros compared to D. pneumosintes in the ozone-treated group. Conclusions: The Subgingival irrigation of ozonated water in conjunction with SRP has beneficial effects in treating patients with chronic periodontitis.

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Identification of Dialister pneumosintes in healthy and chronic periodontitis patients with Type 2 diabetes mellitus and its correlation with the red complex bacteria

Cited by 3 publications

References 22 publications

Bacterial community structure alterations within the colorectal cancer gut microbiome

Bacterial community structure alterations within the colorectal cancer gut microbiome

Citizen-science based study of the oral microbiome in Cystic fibrosis and matched controls reveals major differences in diversity and abundance of bacterial and fungal species

Effectiveness of ozone in the management of chronic periodontitis: A clinico-microbiological study

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