“…Somewhat unexpected associations also occurred exclusively in the matched control networks between Gemella and Granulicatella (occurs in 72 of the 100 matched control networks), and between Rothia and Granulicatella (55 of the 100 control networks), as Granulicatella has also been associated with CF [ 73 , 156 , 157 ] and caries due to its acidogenic nature [ 158 ]. The significant associations seen exclusively in our matched control networks involving Ralstonia and Variovorax [ 159–162 ], Atopobium [ 163 , 164 ], Bradyrhizobium [ 165 ], Hyphomicrobium [ 166 ], Actinomyces [ 167 ], Stomatobaculum [ 168 ], Rothia [ 102 , 163 , 164 ], Clostridiales Family_XIII [ 101 ], Parvimonas [ 97 , 101 , 169 ], Treponema [ 97 , 101 ], Filifactor [ 101 , 170 , 171 ], and Dialister [ 172 , 173 ], all relate to organisms implicated in periodontitis.…”