Identification of dangerous drugs by mass spectrometry

Law, Natalie; Aandahl, Virginia; Fales, Henry M.; Milne, G. W. A.

doi:10.1016/0009-8981(71)90336-6

Cited by 62 publications

(16 citation statements)

References 6 publications

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“…A technique has been developed which combines the high resolving power of GC and the sensitivity and specific ion-detecting ability of the mass spectrometer, thus simplifying considerably the problems encountered previously with mass spectral analysis. GC-mass spectrometry has found wide application in the qualitative identification of drugs (189), especially where small quantities of drugs and metabolites may be involved. The use of stable isotopes in clinical pharmacology, particularly as tracers for drug distribution and metabolism studies, were reviewed (32).…”

Section: Methods-stablementioning

confidence: 99%

Studies with Deuterated Drugs

Blake

Crespi

Katz

1975

Journal of Pharmaceutical Sciences

113

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Section: Methods-stablementioning

confidence: 99%

Studies with Deuterated Drugs

Blake

Crespi

Katz

1975

Journal of Pharmaceutical Sciences

113

View full text Add to dashboard Cite

“…In fact, when MS was first adopted by clinical laboratorians in the early 1970s, it was only an investigative tool for metabolic profiling in urine [ [5] , [6] , [7] , [8] ] and other body fluids [ [9] , [10] , [11] ]. The first clinical laboratory applications of MS were toxicology assays targeting therapeutic drugs, drugs of abuse and their metabolites [ [12] , [13] , [14] , [15] , [16] , [17] ]. With the rapid development of immunoassays in the 1970 to 1980s, first with radioactive labelling [ [18] , [19] , [20] ], then with enzymes [ 21 ] and fluorophores [ 22 ]; and the paradigm shift from phenotyping towards genotyping in the 1990s, largely facilitated by PCR [ 23 ], automated DNA sequencing technologies [ 24 ] and human and microbial genome projects [ 25 , 26 ], the many virtues of MS-based techniques were outshone.…”

Section: Introductionmentioning

confidence: 99%

Clinical Mass Spectrometry in the Bioinformatics Era: A Hitchhiker’s Guide

Chong

Leung

et al. 2018

Computational and Structural Biotechnology Journal

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Mass spectrometry (MS) is a sensitive, specific and versatile analytical technique in the clinical laboratory that has recently undergone rapid development. From initial use in metabolic profiling, it has matured into applications including clinical toxicology assays, target hormone and metabolite quantitation, and more recently, rapid microbial identification and antimicrobial resistance detection by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). In this mini-review, we first succinctly outline the basics of clinical mass spectrometry. Examples of hard ionization (electron ionization) and soft ionization (electrospray ionization, MALDI) are presented to demonstrate their clinical applications. Next, a conceptual discourse on mass selection and determination is presented: quadrupole mass filter, time-of-flight mass spectrometer and the Orbitrap; and MS/MS (tandem-in-space, tandem-in-time and data acquisition), illustrated with clinical examples. Current applications in (1) bacterial and fungal identification, antimicrobial susceptibility testing and phylogenetic classification, (2) general unknown urine toxicology screening and expanded new-born metabolic screening and (3) clinical metabolic profiling by gas chromatography are outlined. Finally, major limitations of MS-based techniques, including the technical challenges of matrix effect and isobaric interference; and novel challenges in the post-genomic era, such as protein molecular variants, are critically discussed from the perspective of service laboratories. Computer technology and structural biology have played important roles in the maturation of this field. MS-based techniques have the potential to replace current analytical techniques, and existing expertise and instrument will undergo rapid evolution. Significant automation and adaptation to regulatory requirements are underway. Mass spectrometry is unleashing its potentials in clinical laboratories.

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“…[*] Die Bedeutung der GC/MS fur dieses Gebiet war klar erkannt[86], jedoch arheiteten die bereits verfugbaren Gerate relativ langsam und waren im allgemeinen fur Nichtroutineprobleme reserviert[87]. [**] DieGegenwart mehrerer[MH] +-ion en,^.…”

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Chemische Ionisation—ein stark Bedeutung gewinnendes massenspektrometrisches Analysenverfahren

Richter

Schwarz

1978

Angew. Chem.

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h w a r z [ * ] Die Art der Ionisation eines Molekiils hat groI3en EinfluIj auf sein Verhalten im Massenspektrometer und damit auf die Informationen, die seinem Massenspektrum entnommen werden konnen. Bei der Chemischen Ionisation wird zunachst ein Reaktandgas, z. B. Methan, durch Elektronen-stoR ionisiert. Die in Ion/Molekul-Reaktionen entstandenen Reaktand-Ionen, vor allem [CH,]', [C2H5]+ und [C3H5]+,reagieren nun ,,chemisch" mit dem Substrat M im Sinne von Saure/Base-Reaktionen zu Ionen vom Typ [MH]+, [M(C,H,)]+ usw., die anschlieBend mehr oder weniger stark fragmentieren. Chemische Ionisation kann aber auch im Sinne von Redox-Reaktionen durch Ladungsaustausch bewirkt werden, indem sich Ionen eines (H-freien) Reaktandgases, z. B. [He] +', mit dem Substrat M zu Molekulionen [MI+' umsetzen. Die Chemische Ionisation kann nach Wunsch mehr oder weniger schonend durchgefuhrt werden, womit sich das AusmaIj der Bruchstuckbildung innerhalb weiter Grenzen steuern 1aBt.

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Identification of dangerous drugs by mass spectrometry

Cited by 62 publications

References 6 publications

Studies with Deuterated Drugs

Studies with Deuterated Drugs

Clinical Mass Spectrometry in the Bioinformatics Era: A Hitchhiker’s Guide

Chemische Ionisation—ein stark Bedeutung gewinnendes massenspektrometrisches Analysenverfahren

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