Identification of Cyanidin-3-arabinoside Extracted from Blueberry as a Selective Protein Tyrosine Phosphatase 1B Inhibitor

Tian, Jinlong; Liao, Xiaojun; Wang, Yuehua; Si, Xu; Shu, Chi; Gong, Ersheng; Xie, Xu; Ran, Xu-Long; Li, Bin

doi:10.1021/acs.jafc.9b06155

Cited by 56 publications

(53 citation statements)

References 30 publications

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“…Protein tyrosine phosphatase 1B (PTP1B) is another promising pharmacological target for the treatment of T2DM as it can reduce blood glucose levels by increasing insulin sensitivity [ 100 ]. Notably, Tian et al [ 101 ] identified anthocyanins isolated from BB as selective inhibitors of PTP1B able to increase glucose consumption on HepG2 (human hepatoma) cells in a dose-dependent manner. Moreover, Nachar et al [ 102 ] performed an in vitro study with phenolic compounds from BB juice fermented with Serratia vaccinii and observed a strong antidiabetic potential in the liver and skeletal muscle, as it was able to regulate key enzymes involved in glycogen synthesis, gluconeogenesis and skeletal muscle glucose uptake.…”

Section: Blueberries Beneficial Outcomes In (Pre)diabetes Progression—a Multi-modal Functional Fruitmentioning

confidence: 99%

Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression

et al. 2021

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Prediabetes, a subclinical impairment between euglycemia and hyperglycemia, is a risk factor for the development of type 2 diabetes mellitus (T2DM) and associated micro- and macrovascular complications. Lifestyle therapy, the first-line treatment of prediabetes, includes physical exercise and dietary regimens enriched in phytochemicals with health-related properties. Blueberries (Vaccinium spp.), given their pleasant taste and great abundance in beneficial phytochemicals, have gained public interest all over the world. Along with a high antioxidant activity, this functional fruit is also well-recognized due to its hypoglycemic and insulin-sensitizing effects and has been recommended for overt T2DM management. Yet blueberries target several other pathophysiological traits, namely gut microbiota dysbiosis and hepatic dysmetabolism, that ensue when prediabetes begins and for which pharmacological interventions tend to be delayed. In this work, we revisited preclinical data from in vitro assays, animal models and human studies, aiming to disclose the potential mechanisms by which blueberries may be a fruitful source of phytochemicals able to prevent (pre)diabetes progression. Collectively, future efforts should focus on longer-term studies with standardized interventions and readouts, particularly in humans, that will hopefully bring more robust evidence and concrete guidance for blueberries’ effective use in prediabetes.

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Section: Blueberries Beneficial Outcomes In (Pre)diabetes Progression—a Multi-modal Functional Fruitmentioning

confidence: 99%

Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression

et al. 2021

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“…The PTP1B Inhibition assay was performed in 96-well plates [25]. The compound (10 µL) was added to the 99-µL reaction buffer solution, which consisted of 10 mM Tris (pH 7.4), 50 mM NaCl, 2 mM dithiothreitol (DTT), 1 mM MnCl 2 , and 10 mM para-nitrophenyl phosphate (pNPP).…”

Section: Ptp1b Inhibition Assaysmentioning

confidence: 99%

New Thiodiketopiperazine and 3,4-Dihydroisocoumarin Derivatives from the Marine-Derived Fungus Aspergillus terreus

Shi

Yao

et al. 2020

Marine Drugs

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Aspergillus terreus has been reported to produce many secondary metabolites that exhibit potential bioactivities, such as antibiotic, hypoglycemic, and lipid-lowering activities. In the present study, two new thiodiketopiperazines, emestrins L (1) and M (2), together with five known analogues (3–7), and five known dihydroisocoumarins (8–12), were obtained from the marine-derived fungus Aspergillus terreus RA2905. The structures of the new compounds were elucidated by analysis of the comprehensive spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HRESIMS), one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) data. This is the first time that the spectroscopic data of compounds 3, 8, and 9 have been reported. Compound 3 displayed antibacterial activity against Pseudomonas aeruginosa (minimum inhibitory concentration (MIC) = 32 μg/mL) and antifungal activity against Candida albicans (MIC = 32 μg/mL). In addition, compound 3 exhibited an inhibitory effect on protein tyrosine phosphatase 1 B (PTP1B), an important hypoglycemic target, with an inhibitory concentration (IC)50 value of 12.25 μM.

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“…The PTP1B inhibition assay was performed in 96-well plates [18]. The compound (10 µL) was added to the 99 µL reaction buffer solution, which consisted of 10 mM Tris (pH 7.4), 50 mM NaCl, 2 mM dithiothreitol (DTT), 1 mM MnCl 2 , and 10 mM para-nitrophenyl phosphate (pNPP).…”

Section: Ptp1b Inhibition Assaysmentioning

confidence: 99%

Benzyl Furanones and Pyrones from the Marine-Derived Fungus Aspergillus terreus Induced by Chemical Epigenetic Modification

Shi

Zhang

et al. 2020

Molecules

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Chemical epigenetic modification on a marine-derived fungus Aspergillus terreus RA2905 using a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), resulted in a significantly changed metabolic profile. A chemical investigation of its ethyl acetate (EtOAc) extract led to the isolation of a racemate of benzyl furanone racemate (±)-1, which further separated chirally as a pair of new enantiomers, (+)- and (−)-asperfuranone (1), together with two new benzyl pyrones, asperpyranones A (2) and B (3). Their structures were elucidated by analysis of the comprehensive spectroscopic data, including one-dimensional (1D) and two-dimensional (2D) NMR, and HRESIMS. The absolute configurations were determined by electronic circular dichroism (ECD) calculation and single-crystal X-ray crystallographic experiment. The structures with benzyl furanone or benzyl pyrone skeletons were discovered from natural products for the first time. Compounds (±)-1, (+)-1, (−)-1, and 2 displayed the antifungal activities against Candida albicans with MIC values of 32, 16, 64, and 64 μg/mL and PTP1B inhibitory activities with the IC50 values of 45.79, 17.32, 35.50, and 42.32 μM, respectively. Compound 2 exhibited antibacterial activity against Pseudomonas aeruginosa with the MIC value of 32 μg/mL.

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Identification of Cyanidin-3-arabinoside Extracted from Blueberry as a Selective Protein Tyrosine Phosphatase 1B Inhibitor

Cited by 56 publications

References 30 publications

Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression

Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression

New Thiodiketopiperazine and 3,4-Dihydroisocoumarin Derivatives from the Marine-Derived Fungus Aspergillus terreus

Benzyl Furanones and Pyrones from the Marine-Derived Fungus Aspergillus terreus Induced by Chemical Epigenetic Modification

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