Identification of CRYAB+KCNN3+SOX9+astro-like and EGFR+PDGFRA+OLIG1+oligo-like tumoral cells in diffuse low-grade gliomas and implication of Notch1 signalling in their genesis
Abstract:IDH1-mutated gliomas are slow growing brain tumours, which progress into high-grade gliomas. They present intra-tumoural cell heterogeneity, but no good markers are available to distinguish the different cell subtypes. The molecular mechanisms underlying the formation of this cell diversity is also ill defined. Here we report that the SOX9 and OLIG1 transcription factors, which specifically label astrocytes and oli-godendrocytes in the normal brain, reveal the presence of two largely non-overlapping tumoural p… Show more
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