“…Faivre et al (2009) recently reported that exons 24-32 represent a hotspot for neonatal MFS and severe forms of MFS. The purpose of this study was to evaluate FBN1 mutations in Taiwanese individuals by using denaturing high performance liquid chromatography (DHPLC) and multiplex ligation-dependent amplification (MLPA) (Liu et al, 1997;Matyas et al, 2002;Kosaki et al, 2005;den Dunnen & White, 2006;Howarth et al, 2007;Kozlowski et al, 2008;Hung et al, 2005Hung et al, , 2006Hung et al, , 2007Hung et al, , 2008aHung et al, , 2008bHung et al, , 2009. DHPLC can detect heteroduplexes of denatured and reannealed PCR amplicons, and has a highcapacity and low-costs.…”