Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of <i>Lonicera japonica</i> using spectrum‑effect correlation

Ding, Jing‐Xin; Liu, Chang; Liu, Xiongwei; Yan, Wei-Na; Li, Wenpei; Shi, Hui; Li, Jiaxin; Tang, Cheng‐Lin

doi:10.3892/etm.2021.10097

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…Ding and colleagues identified eight major chemical components of Lonicera japonica honeysuckle using a combined spectroscopic-effects method, and seven chemical components, including neochlorogenic acid (5-caffeoylquinic acid), chlorogenic acid, 4-dicaffeoylquinic acid, and three isomers of isochlorogenic acid were determined by enzyme-linked immunosorbent assay. All of them have anti-pyretic and anti-endotoxic activities [ 122 ].…”

Section: Research Progress Of Quality Control Methods On CMmentioning

confidence: 99%

Quality evaluation methods of chinese medicine based on scientific supervision: recent research progress and prospects

Chen,

Vong,

Zhang

et al. 2023

Chin Med

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Traditional Chinese medicine (TCM) is increasingly getting attention worldwide, as it has played a very satisfactory role in treating COVID-19 during these past 3 years, and the Chinese government highly supports the development of TCM. The therapeutical theory and efficacies of Chinese medicine (CM) involve the safety, effectiveness and quality evaluation of CM, which requires a standard sound system. Constructing a scientific and reasonable CM quality and safety evaluation system, and establishing high-quality standards are the key cores to promote the high-quality development of CM. Through the traditional quality control methods of CM, the progress of the Q-marker research and development system proposed in recent years, this paper integrated the research ideas and methods of CM quality control and identified effective quality parameters. In addition, we also applied these effective quality parameters to create a new and supervision model for the quality control of CM. In conclusion, this review summarizes the methods and standards of quality control research used in recent years, and provides references to the quality control of CM and how researchers conduct quality control experiments.

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Section: Research Progress Of Quality Control Methods On CMmentioning

confidence: 99%

Quality evaluation methods of chinese medicine based on scientific supervision: recent research progress and prospects

Chen,

Vong,

Zhang

et al. 2023

Chin Med

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“…The dosages of KJG and Flu are calculated as follows: The KJG usage is 400 mg crude drug/kg/day (24000 mg/60kg body weight in adults daily) in patients with depression based on our previous clinical trials. The low dosage (KJG4; 4000 mg crude drug/kg) and high dosage (KJG8; 8000 mg crude drug/kg) in mice are similar at doses approximately 10 and 20 times higher than the adult clinical dosage [ 41 , 42 ]. The Flu usage was 0.333 mg/kg/day (20 mg/60kg body weight in adults daily) in patients with depression, according to the manufacturer’s instruction.…”

Section: Methodsmentioning

confidence: 99%

Kaixin Jieyu Granule attenuates neuroinflammation-induced depressive-like behavior through TLR4/PI3K/AKT/FOXO1 pathway: a study of network pharmacology and experimental validation

Zhai

Zhang

et al. 2023

BMC Complement Med Ther

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Background Kaixin Jieyu Granule (KJG), an improved formula of Kai-xin-san and Si-ni-san, is a highly effective formula with demonstrated efficacy in preventing depression in previous studies. However, the underlying molecular mechanisms of KJG’s antidepressant effects on inflammatory molecules remain unclear. This study aimed to explore the therapeutic effects of KJG on depression using network pharmacology and experimental validation. Methods We employed a multi-faceted approach, combining high-performance liquid chromatography (HPLC), network pharmacology, and molecular docking, to unravel the underlying mechanisms of KJG’s anti-depressant effects. To confirm our findings, we conducted at least two independent in vivo experiments on mice, utilizing both the chronic unpredictable mild stress (CUMS)-induced and lipopolysaccharide (LPS)-induced models. Furthermore, the results of in vivo experiments were verified by in vitro assays. Behavioral tests were utilized to evaluate depression-like behaviors, while Nissl staining was used to assess morphological changes in the hippocampus. Pro-inflammatory cytokines and pathway-related protein expressions were determined using a combination of immunofluorescence staining, enzyme-linked immunosorbent assay (ELISA), and Western Blotting (WB). Results Our network-based approaches indicated that ginsenoside Rg1 (GRg1) and saikosaponin d (Ssd) are the major constituents of KJG that exert an anti-depressant effect by regulating TLR4, PI3K, AKT1, and FOXO1 targets through the toll-like receptor, PI3K/AKT, and FoxO pathways. In vivo, KJG can attenuate depression-like behaviors, protect hippocampal neuronal cells, and reduce the production of pro-inflammatory mediators (TNF-α, IL-6, and IL-1β) by repressing TLR4 expression, which was regulated by the inhibition of FOXO1 through nuclear exportation. Furthermore, KJG increases the expression levels of PI3K, AKT, p-PI3K, p-AKT, and p-PTEN. Our in vitro assays are consistent with our in vivo studies. On the other hand, the above effects can be reversed by applying TAK242 and LY294002. Conclusion Our findings suggest that KJG can exert anti-depressant effects by regulating neuroinflammation through the PI3K/AKT/FOXO1 pathway by suppressing TLR4 activation. The study’s findings reveal novel mechanisms underlying the anti-depressant effects of KJG, presenting promising avenues for the development of targeted therapeutic approaches for depression.

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“…X. Ding et al, (2021) nghiên cứu xác định các hợp chất có tác dụng hạ sốt và chống nội độc tố LPS (lipopolysaccharide) trên chuột cống của ba loài thuộc chi Lonicera. Kết quả của nghiên cứu cho thấy các dẫn xuất của acid caffeoylquinic gồm có acid neochlorogenic (72), acid chlorogenic (64), acid cryptochlorogenic (80), acid isochlorogenic A (66), acid isochlorogenic B (84), acid isochlorogenic C (73) trong KNH đóng vai trò hiệp đồng hạ sốt và chống nội độc tố LPS [36].…”

Section: Các Tác Dụng Khácunclassified

“…Về tác dụng sinh học của các chất phân lập được từ KNH, hầu hết nghiên cứu công bố từ loài L. japonica. Các nghiên cứu chỉ ra rằng hợp chất phenolic trong KNH có tác dụng kháng khuẩn [41,43], kháng virus [31,[44][45], chống oxy hóa [47][48][49], chống viêm [19,24,30,36], độc với tế bào, chống ung thư [17,22,53], bảo vệ gan [17,55], hạ sốt, chống nội độc tố vi khuẩn [36], chống dị ứng [60], chống đái tháo đường [56][57], bảo vệ tim [58][59],... Các tác dụng sinh học này đa số là các polyphenol như dẫn xuất của acid caffeoylquinic, flavonoid. Cùng với tác dụng sinh học của các nhóm hợp chất khác có trong KNH [6,8], đã góp phần chứng minh tác dụng, công dụng của KNH sử dụng trong y học cổ truyền.…”

Section: Bàn Luậnunclassified

Flos Lonicerae: A Review of Chemical Structures and Biological Activities of Phenolic Derivatives

Tuan

Anh²,

Hải³

et al. 2022

MPS

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Flos Lonicerae, a widely used Vietnamese medicinal material, is the dried buds or flowers of Lonicera japonica Thunb., and several other species of genus Lonicera such as Lonicera dasystyla Rehd., Lonicera confusa DC., Lonicera cambodiana Pierre ex Danguy, belonging to the family Caprifoliaceae. This material has been used for a long time in traditional medicine for clearing heat, removing toxins, and dispersing wind heat. According to a variety of recent phytochemistry and biological studies that we systematically summarized, Flos Lonicerae contains 129 phenolic derivatives including 48 flavonoids, 13 lignans and neolignans, 55 phenolic acid derivatives, and 13 other phenolic compounds. These phenolic compounds have remarkable biological effects such as antibacterial, antiviral, antioxidant, anti-inflammatory, anti-cancer, hepatoprotective, anti-endotoxin, anti-allergic, anti-diabetic, cardioprotective, anti-allergic activities, etc. In particular, chlorogenic acid, a prominent component with significant biological activities, is utilized as a marker compound to evaluate the quality of Flos Lonicerae in the Vietnamese and Chinese Pharmacopoeia.

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Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of Lonicera japonica using spectrum‑effect correlation

Cited by 6 publications

References 33 publications

Quality evaluation methods of chinese medicine based on scientific supervision: recent research progress and prospects

Quality evaluation methods of chinese medicine based on scientific supervision: recent research progress and prospects

Kaixin Jieyu Granule attenuates neuroinflammation-induced depressive-like behavior through TLR4/PI3K/AKT/FOXO1 pathway: a study of network pharmacology and experimental validation

Flos Lonicerae: A Review of Chemical Structures and Biological Activities of Phenolic Derivatives

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