Identification of compatibility between ooplasmic factor and sperm gene in the intersubspecific crosses involving DDK and PWK mice strains

Song, Gendi; Wang, Tingting; Guo, Jie; Lei, Jiang; Li, Chunli; Zhen-yu, Zheng; Zhao, Weidong

doi:10.1016/j.jgg.2011.08.008

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Subsequently, Zhao et al (2002) reported that DDK females are fully fertile when crossed to males of MOM (M. m. molossinus) and CASP (M. m. castaneus) strains. Song et al (2011) also presented that DDK females are fully fertile when crossed with PWK, which belongs to M. m. musculus subspecies and is same as the PERA and PERC mice (Ideraabdullah et al 2007). However, that work did not discuss whether there existed the possibility of modifier genes.…”

Section: Discussionmentioning

confidence: 95%

Locating a modifier gene of Ovum mutant through crosses between DDK and C57BL/6J inbred strains in mice

Tan

Song

et al. 2016

J Genet

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A striking infertile phenotype has been discovered in the DDK strain of mouse. The DDK females are usually infertile when crossed with males of other inbred strains, whereas DDK males exhibit normal fertility in reciprocal crosses. This phenomenon is caused by mutation in the ovum (Om) locus on chromosome 11 and known as the DDK syndrome. Previously, some research groups reported that the embryonic mortality deviated from the semilethal rate in backcrosses between heterozygous (Om/+) females and males of other strains. This embryonic mortality exhibited an aggravated trend with increasing background genes of other strains. These results indicated that some modifier genes of Om were present in other strains. In the present study, a population of N₂2 (Om/+) females from the backcrosses between C57BL/6J (B6) and F₁ (B6♀ × DDK♂) was used to map potential modifier genes of Om. Quantitative trait locus showed that a major locus, namely Amom1 (aggravate modifier gene of Om 1), was located at the middle part of chromosome 9 in mice. The Amom1 could increase the expressivity of Om gene, thereby aggravating embryonic lethality when heterozygous (Om/+) females mated with males of B6 strain. Further, the 1.5 LOD-drop analysis indicated that the confidence interval was between 37.54 and 44.46 cM, ~6.92 cM. Amom1 is the first modifier gene of Om in the B6 background.

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Section: Discussionmentioning

confidence: 95%

Locating a modifier gene of Ovum mutant through crosses between DDK and C57BL/6J inbred strains in mice

Tan

Song

et al. 2016

J Genet

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Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice

Liu

Wang

Zhao

et al. 2014

Developmental Biology

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Telomere clustering is a widespread phenomenon among eukaryotes. However, the molecular mechanisms that regulate formation of telomere clustering in mammalian meiotic prophase I, are still largely unknown. Here, we show that CDK2, especially p39(cdk2), as a potential meiosis-specific connector interaction with SUN1 mediates formation of telomere clustering during mouse meiosis. The transition from CDK2 to p-CDK2 also regulates the progression from homologous recombination to desynapsis by interacting with MLH1. In addition, disappearance of CDK2 on the telomeres and of p-CDK2 on recombination sites, were observed in Sun1(-/-) mice and in pachytene-arrested hybrid sterile mice (pwk×C57BL/6 F1), respectively. These results suggest that transition from CDK2 to p-CDK2 plays a critical role for regulating meiosis progression.

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Identification of compatibility between ooplasmic factor and sperm gene in the intersubspecific crosses involving DDK and PWK mice strains

Cited by 2 publications

References 24 publications

Locating a modifier gene of Ovum mutant through crosses between DDK and C57BL/6J inbred strains in mice

Locating a modifier gene of Ovum mutant through crosses between DDK and C57BL/6J inbred strains in mice

Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice

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