Identification of colorectal cancer metastasis markers by an angiogenesis-related cytokine-antibody array

Abajo, A.M. SÁnchez De; Bitarte, Nerea; Zárate, Ruth; Boni, Valentina; López, Inés; González-Huárriz, Marisol; Rodríguez, Javier; Bandrés, Eva; Garcı́a-Foncillas, Jesús

doi:10.3748/wjg.v18.i7.637

Cited by 37 publications

(31 citation statements)

References 37 publications

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“…There are some evidences that VEGF is early expressed during cancer progression (43) Ang-2 could be overexpressed in latter stages of the disease, as suggested by Abajo and colleagues (44). In line with this hypothesis, the production of Ang-2 within the tumor microenvironment could depend on VEGF (44). Moreover, Ang-2 expression was shown to be correlated with colorectal cancer stages and progression (44,45).…”

Section: Cancer Epidemiol Biomarkers Prev; 24(3) March 2015supporting

confidence: 56%

“…In line with this hypothesis, the production of Ang-2 within the tumor microenvironment could depend on VEGF (44). Moreover, Ang-2 expression was shown to be correlated with colorectal cancer stages and progression (44,45). Nevertheless the precise role of Ang-2 cancer progression needs to be further clarified.…”

Section: Cancer Epidemiol Biomarkers Prev; 24(3) March 2015mentioning

confidence: 87%

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Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma

Jary

Vernerey

Lecomte

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Baseline prognostic biomarkers stratifying treatment strategies in first-line metastatic colorectal cancer (mCRC) are lacking. Angiopoietin-2 (Ang-2) is proposed as a potential biomarker in several cancers. We therefore decided to establish the additional prognostic value of Ang-2 for overall survival (OS) in patients with first-line mCRC.Methods: We enrolled 177 patients treated with a bevacizumab containing chemotherapy in two prospective phase II clinical trials. Patient plasma samples were collected at baseline. ELISAs were used to measure Ang-2.Results: The multivariable Cox model identified increased lactate dehydrogenase [HR, 1.60; 95% confidence interval (CI), 1.04-2.45; P ¼ 0.03] and Ang-2 log-transformation level (HR, 1.59; 95% CI, 1.14-2.21; P ¼ 0.0065) as two significant independent OS prognostic factors. It exhibited good calibration (P ¼ 0.8) and discrimination (C-index: 0.64; 95% CI, 0.58-0.68). Ang-2 parameter inclusion in the GERCOR reference model signifi-

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Section: Cancer Epidemiol Biomarkers Prev; 24(3) March 2015supporting

confidence: 56%

Section: Cancer Epidemiol Biomarkers Prev; 24(3) March 2015mentioning

confidence: 87%

Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma

Jary

Vernerey

Lecomte

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Interleukin 6 (IL-6) is a pleiotropic cytokine involved in the regulation of acute-phase reaction, inflammation, hematopoiesis, and the transition from innate to acquired immunity (Fielding et al, 2008;Abajo et al, 2012). Endogenous IL-6 plays a crucial anti-inflammatory role in both local and systemic acute inflammatory responses in mouse models.…”

Section: Discussionmentioning

confidence: 99%

Serum cytokine modulation after Staphylococcus hyicus infection in BALB/c mice

Wang

Zhang

et al. 2015

Genet. Mol. Res.

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“…Angiogenesis and lymphangiogenesis are complex processes that depend on angiogenic factors secreted by tumor cells and stroma cells [24,25]. The multistep processes of lymphangiogenesis and angiogenesis accompany the multistage development of tumors [26,27]. The development of a non-metastasized tumor into a metastatic tumor causes numerous changes within the tumor microenvironment [28].…”

Section: Discussionmentioning

confidence: 99%

Inverse correlation of phospho-KDR/Flk-1 expression and stage of colorectal cancer: implication of the significance of neoangiogenesis in activated VEGFR-2 expressing early stage colorectal adenocarcinomas

Lin¹,

Chang²,

Lin³

et al. 2014

pjp

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The activation of vascular endothelial cell growth factor receptors (VEGFRs) plays an essential role in cancer progression. In this study, we investigated the expression of phosphorylated VEGFR-2 (or phospho-KDR/Flk-1), the activated form of VEGFR-2, in human colorectal adenomas and colorectal adenocarcinomas. Phospho-KDR/Flk-1 showed weak expression in the normal colorectal tissue. Phospho-KDR/Flk-1 was mainly stained in the cytoplasm of colorectal adenomas, and was stained in both the cytoplasm and nuclei colorectal adenocarcinomas. There was no indication of increased phospho-KDR/Flk-1 expression in the colorectal adenocarcinomas, as compared to that of colorectal adenomas. Furthermore, there was an inverse relationship of phospho-KDR/Flk-1 expression with cancer stage (p < 0.0001), lymph node metastasis (p = 0.011), and distant metastasis (p = = 0.021) of the colorectal adenocarcinomas. Our results indicate that early stage colorectal adenocarcinomas with highly activated (phosphorylated) VEGFR-2 expression may indicate the significance of neoangiogenesis of the tumors.

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Identification of colorectal cancer metastasis markers by an angiogenesis-related cytokine-antibody array

Abstract: A distinct angiogenesis-related expression pattern characterizes metastatic CRC cell lines. Factors other than VEGF appear as prognostic markers and intervention targets in the metastatic CRC setting.

Cited by 37 publications

References 37 publications

Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma

Prognostic Value of Angiopoietin-2 for Death Risk Stratification in Patients with Metastatic Colorectal Carcinoma

Serum cytokine modulation after Staphylococcus hyicus infection in BALB/c mice

Inverse correlation of phospho-KDR/Flk-1 expression and stage of colorectal cancer: implication of the significance of neoangiogenesis in activated VEGFR-2 expressing early stage colorectal adenocarcinomas

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