Identification of clinical parameters associated with serum oxidative stress in patients with rheumatoid arthritis

Nakajima, Arata; Aoki, Yasuchika; Shibata, Yoshifumi; Sonobe, Masato; Terajima, Fumiaki; Takahashi, Hiroshi; Saito, M.; Taniguchi, S.; Yamada, Manabu; Nakagawa, Kōichi

doi:10.3109/14397595.2014.891495

Cited by 34 publications

(54 citation statements)

References 27 publications

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“…In our study, patients were prospectively followed, and patients with comorbid diabetes mellitus, chronic kidney disease more than grade 3, and chronic obstructive pulmonary disease (COPD) were excluded, because these comorbidities permanently and endogenously upregulate oxidative stress markers. Therefore, our study may provide better evidence than previous reports [8] [9].…”

Section: Discussioncontrasting

confidence: 54%

“…A simple test for d-reactive oxygen metabolites (d-ROM) has been developed and is able to detect the total amount of ROS in the body [7]. Previous reports demonstrated that d-ROM values in RA patients were significantly higher than those in osteoarthritis patients [8], and that d-ROM levels are significantly correlated with disease activity in RA [9].…”

Section: Introductionmentioning

confidence: 99%

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Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis

Kondo¹,

Arai²,

Netsu³

et al. 2017

OJRA

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To determine the effect of tocilizumab (TCZ) on reactive oxygen species (ROS) in 11 patients with rheumatoid arthritis (RA), reactive oxygen metabolites (d-ROM) were measured using a Free Radical Elective Evaluator. The Disease Activity Score (DAS28) and matrix metalloproteinase-3 (MMP-3) level were also evaluated. d-ROM measured 392 ± 110 Carratelli units [U. CARR] on initiation of TCZ, and significantly decreased to 237 ± 82, 248 ± 88, and 226 ± 91 U.CARR after 3, 6, and 12 months, respectively (p < 0.05). The DAS28-4-ESR was 4.77 ± 1.0 on initiation of TCZ, and significantly decreased to 2.19 ± 1.23, 1.51 ± 0.71, and 1.48 ± 0.48 after 3, 6, and 12 months, respectively (p < 0.05). Serum MMP-3 level was 197 ± 150 ng/ml on initiation of TCZ, and was significantly decreased to 92 ± 56, 73 ± 53, and 69 ± 41 ng/ml after 3, 6, and 12 months, respectively (p < 0.05). Pearson analysis showed that d-ROM value was significantly correlated with DAS28 (r = 0.543, p < 0.05), but not with MMP-3 (r = 0.174, p = 0.29). TCZ was found to rapidly and significantly decrease ROS in patients with RA, and d-ROM value may be useful as a marker of disease activity of RA.

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Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis

Kondo¹,

Arai²,

Netsu³

et al. 2017

OJRA

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“…31) Blood d-ROMs level increases in diseases with enhanced oxidative stress, and decreases by treatment that reduces oxidative stress. 32,33) Regarding the effect of resveratrol on oxidative stress, a report has shown that resveratrol treatment decreases ROS production induced by TNF-α or NF-κB in human vascular endothelial cells. 34) Oxidative stress is known to be elevated in diabetic conditions through the generation of advanced glycation end products (AGEs) and activation of NADPH oxidase.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Patients With Type 2 Diabetes Mellitus

et al. 2017

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SummaryResveratrol has been reported to have potent anti-atherosclerotic effects in animal studies. However, there are few interventional studies in human patients with atherosclerogenic diseases. The cardio-ankle vascular index (CAVI) reflects arterial stiffness and is a clinical surrogate marker of atherosclerosis. The aim of the present study was to investigate the effect of resveratrol on arterial stiffness assessed by CAVI in patients with type 2 diabetes mellitus (T2DM).In this double-blind, randomized, placebo-controlled study, 50 patients with T2DM received supplement of a 100-mg resveratrol tablet (total resveratrol: oligo-stilbene 27.97 mg/100 mg/day) or placebo daily for 12 weeks. CAVI was assessed at baseline and the end of study. Body weight (BW), blood pressure (BP), glucose and lipid metabolic parameters, and diacron-reactive oxygen metabolites (d-ROMs; an oxidative stress marker) were also measured.Resveratrol supplementation decreased systolic BP (-5.5 ± 13.0 mmHg), d-ROMs (-25.6 ± 41.8 U.CARR), and CAVI (-0.4 ± 0.7) significantly (P < 0.05) and decreased BW (-0.8 ± 2.1 kg, P = 0.083) and body mass index (-0.5 ± 0.8 kg/m 2 , P = 0.092) slightly compared to baseline, while there were no significant changes in the placebo group. Decreases in CAVI and d-ROMs were significantly greater in the resveratrol group than in the placebo group. Multivariate logistic regression analysis identified resveratrol supplementation as an independent predictor for a CAVI decrease of more than 0.5.In conclusion, 12-week resveratrol supplementation may improve arterial stiffness and reduce oxidative stress in patients with T2DM. Resveratrol may be beneficial in preventing the development of atherosclerosis induced by diabetes. However, a large-scale cohort study is required to validate the present findings. (Int Heart J 2017; 58: 577-583)

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“…[34] Different mechanism may explain the efficacy of D-002 in this model, but obviously since it has been shown anti-inflammatory action [16 -20, 23, 24] and the ability to inhibit COX and 5-LOX enzymes [21,22] should be one of the mechanism that support the effects here seen, at least partially. Taking into account that the increase of oxidative stress has been linked with the development of RA and that some antioxidants have demonstrated efficacy in RA model, [35][36][37][38] we can hypothesize that the antioxidant effects of D-002 could have contributed to the present results, preferred hypothesis. Nevertheless, our study was not focused on the mechanisms whereby D-002 may be effective, but on elucidating whether its oral administration is able to reduce the distinctive histopathological lesions in this model of RA, as demonstrated.…”

Section: International Journal Of Pharmacology Phytochemistry and Etmentioning

confidence: 77%

Effects of Oral Administration of D-002 (Beeswax Alcohols) on Histological and Functional Outcomes in a Rat Model of Antigen-Induced Arthritis: Preliminary Study

Puig¹,

Castaño²,

Ferreiro³

et al. 2016

IJPPE

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Abstract. D-002, a mixture of higher aliphatic beeswax alcohols, has been shown to display antiinflammatory effects associated with the dual inhibition of ciclooxygenase and 5-lipoxygenase. Oral D-002 supplementation has been effective in experimental osteoarthritis, ameliorating all features of joint histopathology. Clinical studies have demonstrated that D-002 reduces osteoarthritis symptoms. However, D-002 effects on experimental models of rheumatoid arthritis (RA) have not been evaluated. To investigate whether D-002 improves histopathological and functional outcomes in a rat model of antigen-induced arthritis. First experiment. Rats were randomized into a negative vehicle-control (sham) and four groups injected with complete Freund's adjuvant (CFA): a positive vehicle-control, three treated with D-002 (50, 200 and 400 mg/kg/day) for 21 days. Second experiment. Rats were randomized into a sham and four CFA-injected groups: a positive vehiclecontrol, two treated with D-002 (25 and 100 mg/kg/day), one with methorexate (MTX) (0.3 mg/kg) for 28 days. Arthritis severity was evaluated by bodyweight loss, decreased exploratory activity and histological changes of tarsal joint and spleen samples in both experiments, except the exploratory activity, assessed only in the first one. CFA injection decreased the bodyweight and the exploratory activity, and induced infiltration of mononuclear cells, pannus formation and vascularity in the tarsal joint of positive control rats. These changes were significantly and markedly ameliorated by D-002 as compared to the positive control. MTX also reversed CFA-induced changes. The reduction of the infiltration of mononuclear cell with D-002 400 mg/kg was greater (80.9%) than with MTX (66.8%), but effects on other variables were similar. No abnormalities in spleen samples of D-002-treated groups were detected. This is the first report demonstrating the efficacy of oral treatment with D-002 in a rat model of antigen-induced arthritis. Results suggest that D-002 could help manage RA, but confirmation of such potential benefit requires extensive further research.

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Identification of clinical parameters associated with serum oxidative stress in patients with rheumatoid arthritis

Abstract: The serum level of ROM was associated with CRP and DAS28-ESR, suggesting that ROM, in conjunction with CRP and MMP3, may be able to be used as a new biological disease marker to evaluate the disease activity of RA.

Cited by 34 publications

References 27 publications

Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis

Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis

Resveratrol Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Patients With Type 2 Diabetes Mellitus

Effects of Oral Administration of D-002 (Beeswax Alcohols) on Histological and Functional Outcomes in a Rat Model of Antigen-Induced Arthritis: Preliminary Study

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