Identification of Clinical and Genetic Parameters Associated with Hidradenitis Suppurativa in Inflammatory Bowel Disease

Janse, Ineke C.; Koldijk, Marjolein J.; Spekhorst, Lieke M.; Vila, Arnau Vich; Weersma, Rinse K.; Dijkstra, Gerard; Hórvath, Barbara

doi:10.1097/mib.0000000000000579

Cited by 46 publications

(44 citation statements)

References 39 publications

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“…The increased rate of IBD and HS in the younger and African‐American population may suggest that a genetic component may play an important role in the pathogenesis of disease in these patient populations as compared to those with IBD alone. This is supported by studies identifying a potential genetic link between the two diseases . Such patients may also be at particularly high risk of morbidity if exposed to environmental factors such as smoking.…”

Section: Discussionmentioning

confidence: 87%

“…This is supported by studies identifying a potential genetic link between the two diseases. 12 Such patients may also be at particularly high risk of morbidity if exposed to environmental factors such as smoking.…”

Section: Unregulated Inflammation and Immune Dysregulation Have Beenmentioning

confidence: 99%

“…For example, it has been well‐established that smoking is a worsening risk factor in HS as well as Crohn's disease . Also, certain genes such as SULT1B1 and SULT1E1 have been associated with HS as well as IBD . Given the strong association between HS and IBD, specifically with Crohn's disease, we sought to explore the burden of HS on patients with IBD.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 Also, certain genes such as SULT1B1 and SULT1E1 have been associated with HS as well as IBD. 12 Given the strong association between HS and IBD, specifically with Crohn's disease, we ª 2018 The International Society of Dermatology International Journal of Dermatology 2018, 57, 547-552 sought to explore the burden of HS on patients with IBD. Numerous studies have explored the prevalence and important associations of IBD and HS; however, no other study has specifically studied the medical and financial burden of HS on patients with IBD.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The in‐hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014

et al. 2018

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Section: Discussionmentioning

confidence: 87%

Section: Unregulated Inflammation and Immune Dysregulation Have Beenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The in‐hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014

et al. 2018

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“…Moreover, associations between hidradenitis suppurativa or dissecting cellulitis of the scalp with pyoderma gangrenosum are not infrequent [14]. A recent study demonstrated the association between hidradenitis suppurativa and the inflammatory bowel disease, especially Crohn's disease [15]. …”

Section: Discussionmentioning

confidence: 99%

PASS Syndrome: An IL-1-Driven Autoinflammatory Disease

Leuenberger

Berner²,

J³

et al. 2016

Dermatology

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PASS syndrome is a rare inflammatory disease characterized by a chronic-relapsing course of pyoderma gangrenosum, acne vulgaris, hidradenitis suppurativa and ankylosing spondylitis. Here, we describe a case of a patient with spontaneously recurrent purulent skin lesions along with seronegative spondylarthritis consistent with the PASS syndrome. During his disease exacerbation, the patient displayed episodes of fever along with elevated serum levels of interleukin (IL)-1β. Skin lesions were characterized by sterile neutrophilic infiltrates and showed a rapid response to the IL-1 receptor antagonist anakinra (Kineret®) consistent with the autoinflammatory nature of this disease. However, unlike other autoinflammatory diseases such as PAPA and PAPASH, we did not find mutations in the gene PSTPIP1, raising the possibility that other specific mutations in the IL-1 pathway may be involved.

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Overall and Subgroup Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa

2018

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idradenitis suppurativa (HS) is a debilitating disease of the pilosebaceous unit that results in painful nodules and abscesses commonly involving axillary, inguinal, perineal, and inframammary regions. The inherent unpredictability of the disease, both with respect to course and response to treatment, poses substantial challenges for patients. 1 Hidradenitis suppurativa shares several clinical features with Crohn disease (CD), and previous observational studies have suggested a link between the 2 conditions. However prevalence estimates for CD among patients with HS are highly variable. 2-7 Moreover, population-based prevalence estimates and strength of association analyses from outside of Europe are lacking. We sought to evaluate the prevalence of CD among patients with HS in the United States. Methods Patient Population This was a cross-sectional analysis using a multiple health system data analytics and research platform (Explorys) developed by IBM Corporation, Watson Health. 8 Clinical information from electronic medical records, laboratories, practice IMPORTANCE Limited evidence supports a link between hidradenitis suppurativa (HS) and Crohn disease (CD), and this relationship has not been established in the United States. OBJECTIVE To evaluate the prevalence of CD among patients with HS in the United States and to determine the strength of association between the 2 conditions. DESIGN, SETTING, AND PARTICIPANTS Cross-sectional analysis of data from 51 340 patients with HS identified using electronic health records data in the Explorys multiple health system data analytics and research platform, which includes data from more than 50 million unique patients across all US census regions. MAIN OUTCOMES AND MEASURES Primary outcome was diagnosis of CD. RESULTS Of the 18 455 660 total population considered, 51 340 had HS (35 000 women). Of these patients with HS, 29 010 (56.5%) were aged 18 to 44 years; 17 580 (34,2%), 45 to 64 years; and 4750 (9.3%), 65 years or older. Prevalence of CD among patients with HS was 2.0% (1025/51 340), compared with 0.6% (113 360/18 404 260) among those without HS (P < .001). Prevalence of CD was greatest among patients with HS who were white (2.3%), aged 45 to 64 years (2.4%), nonobese (2.8%), and tobacco smokers (2.3%). In univariable and multivariable analyses, patients with HS had 3.29 (95% CI, 3.09-3.50) and 3.05 (95% CI, 2.87-3.25) times the odds of having CD, respectively, compared with patients without HS. Crohn disease was associated with HS across all patient subgroups. The association was strongest for men (OR, 3.61; 95% CI, 3.24-4.03), patients aged 45 to 64 years (OR, 3.49; 95% CI, 3.16-3.85), nonobese patients (OR, 4.09; 95% CI, 3.69-4.54), and nonsmokers (OR, 3.44; 95% CI, 3.10-3.82). CONCLUSIONS AND RELEVANCE These data suggest that patients with HS are at risk for CD. Gastrointestinal symptoms or signs suggestive of CD warrant additional evaluation by a gastroenterologist.

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Identification of Clinical and Genetic Parameters Associated with Hidradenitis Suppurativa in Inflammatory Bowel Disease

Cited by 46 publications

References 39 publications

The in‐hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014

The in‐hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014

PASS Syndrome: An IL-1-Driven Autoinflammatory Disease

Overall and Subgroup Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa

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