Identification of circulating MicroRNAs as novel potential biomarkers for hepatocellular carcinoma detection: a systematic review and meta-analysis

Li, G.; Shen, Qingrong; Li, C.; Li, D.; Chen, J.; He, Miao

doi:10.1007/s12094-015-1294-y

Cited by 43 publications

(36 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, exosomal miRNA-21 has been considered as potential biomarker of cancer [349]. Furthermore, increased expression of circulating miRNA-21 has been reported in patients with breast cancer [350], lung cancer [350], colorectal carcinoma [350], and hepatocellular carcinoma [351,352,353]. Hepatocellular carcinoma has recently been related to increased consumption of cow’s milk [354].…”

Section: Milk-mediated Epigenetic Signaling and Diseases Of Civilmentioning

confidence: 99%

Milk’s Role as an Epigenetic Regulator in Health and Disease

2017

View full text Add to dashboard Cite

Abstract:It is the intention of this review to characterize milk's role as an epigenetic regulator in health and disease. Based on translational research, we identify milk as a major epigenetic modulator of gene expression of the milk recipient. Milk is presented as an epigenetic "doping system" of mammalian development. Milk exosome-derived micro-ribonucleic acids (miRNAs) that target DNA methyltransferases are implicated to play the key role in the upregulation of developmental genes such as FTO, INS, and IGF1. In contrast to miRNA-deficient infant formula, breastfeeding via physiological miRNA transfer provides the appropriate signals for adequate epigenetic programming of the newborn infant. Whereas breastfeeding is restricted to the lactation period, continued consumption of cow's milk results in persistent epigenetic upregulation of genes critically involved in the development of diseases of civilization such as diabesity, neurodegeneration, and cancer. We hypothesize that the same miRNAs that epigenetically increase lactation, upregulate gene expression of the milk recipient via milk-derived miRNAs. It is of critical concern that persistent consumption of pasteurized cow's milk contaminates the human food chain with bovine miRNAs, that are identical to their human analogs. Commercial interest to enhance dairy lactation performance may further increase the epigenetic miRNA burden for the milk consumer.

show abstract

Section: Milk-mediated Epigenetic Signaling and Diseases Of Civilmentioning

confidence: 99%

Milk’s Role as an Epigenetic Regulator in Health and Disease

2017

View full text Add to dashboard Cite

show abstract

“…By targeting the mRNAs of protein-coding genes, miRNAs play a critical role in a variety of biological and pathological processes [13][14][15][16]. As a result, using miRNAs as biomarkers have received widespread attention [17][18][19]. While most miRNAs are found intracellularly, a significant number have also been observed extracellularly in saliva, urine and breast milk [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

miRNA Expression Profile of Saliva in Subjects of Yang Deficiency Constitution and Yin Deficiency Constitution

Chen

Wu²,

Yao

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Based on the theory of constitution in Traditional Chinese Medicine (TCM), the Chinese Han population has been classified into nine constitutions. Of these, Yang deficiency constitution mainly exhibit cold intolerance while Yin deficiency constitution mainly exhibit heat intolerance. Some studies have been carried out to explore the modern genetic and biological basis of such constitution classification, but more remains to be done. MicroRNA (miRNA) serves as post-transcriptional regulators of gene expression and may play a role in the classification process. Here, we examined miRNA expression profile of saliva to further improve the comprehensiveness of constitution classification. Methods: Saliva was collected from Chinese Han individuals with Yang deficiency, Yin deficiency and Balanced constitutions (n=5 each), and miRNA expression profile was determined using the Human miRNA OneArray®v7. Based on 1.5 Fold change, means log₂|Ratio|≥0.585 and P-value< 0.05, differentially expressed miRNA was screened. Target genes were predicted using DIANA-TarBasev7.0 and analysis of KEGG pathway was carried out using DIANA-mirPathv.3. Results: We found that 81 and 98 differentially expressed miRNAs were screened in Yang deficiency and Yin deficiency constitution, respectively. Among them, 16 miRNAs were identical and the others were unique. In addition, the target genes that are regulated by the unique miRNAs were significantly enriched in 27 and 20 signaling pathways in Yang deficiency and Yin deficiency constitution, respectively. Thyroid hormone signaling pathway is present in both constitutions. These unique miRNAs that regulated target genes of thyroid hormone signaling pathway may be associated with cold intolerance or heat intolerance. Conclusion: The results of our study show that Yang deficiency and Yin deficiency constitutions exhibit systematic differences in miRNA expression profile. Moreover, the distinct characteristics of TCM constitution may be explained, in part, by differentially expressed miRNAs.

show abstract

“…There is strong evidence that approximately 20–80% of transcribed human genes are regulated by miRNAs [4]. miRNAs are present not only in tissue cells but also in body fluids, as a result of passive leakage due to cell death, or they are actively secreted through exosomes from cells [4, 5]. …”

Section: Introductionmentioning

confidence: 99%

Detection of MicroRNA in Hepatic Cirrhosis and Hepatocellular Carcinoma in Hepatitis C Genotype-4 in Egyptian Patients

Demerdash

Hussien

Hassouna

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

Background In Egypt, the prevalence of chronic hepatitis C (CHC) infection is 13.8% of whole population and about 80% of the patients with hepatocellular carcinoma have underling hepatitis C. Aim This study was designed to assess the diagnostic value of plasma miR-122 and miR-21 in patients with CHC, genotype-4, to detect fibrosis progression versus noninvasive indices and their diagnostic value in detection of early stages of hepatocellular carcinoma (HCC). Methodology A prospective study that included 180 patients, divided into 3 groups: healthy controls (group I), CHC patients (group II), and hepatitis C patients with HCC (group III); all cases were subjected to thorough clinical, radiological, and laboratory investigations. Selected biomarkers were evaluated and correlated with degree of liver damage. Results revealed that miR-122 followed by miR-21 had the highest efficiency in prediction of liver cell damage. Also, miR-21 was strongly correlated with vascular endothelial growth factor (VEGF) and alpha fetoprotein (α-FP) in HCC patients. Conclusions Plasma miR-122 and miR-21 had strong correlation with degree fibrosis in HCV genotype-4 patients; consequently they can be considered as potential biomarker for early detection of hepatic fibrosis. Moreover, miR-21 can be used as a potential biomarker, for early detection of HCC combined with VEGF and α-FP.

show abstract

Identification of circulating MicroRNAs as novel potential biomarkers for hepatocellular carcinoma detection: a systematic review and meta-analysis

Abstract: Circulating miR-21 has highest level of diagnostic efficiency among three miRNAs candidate biomarkers (miR-21, miR-122, and miR-223) for detection of HCC.

Cited by 43 publications

References 58 publications

Milk’s Role as an Epigenetic Regulator in Health and Disease

Milk’s Role as an Epigenetic Regulator in Health and Disease

miRNA Expression Profile of Saliva in Subjects of Yang Deficiency Constitution and Yin Deficiency Constitution

Detection of MicroRNA in Hepatic Cirrhosis and Hepatocellular Carcinoma in Hepatitis C Genotype-4 in Egyptian Patients

Contact Info

Product

Resources

About