Identification of chromosome anomalies in the blastic phase of chronic myelocytic leukemia (CML) by Giemsa- and quinacrine-banding techniques

Hossfeld, Dieter K.

doi:10.1007/bf00282208

Cited by 18 publications

(3 citation statements)

References 11 publications

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“…While metaphases with randomly missing chromosomes seen could be caused by a technical artifact, e.g., broken metaphases, it would be highly unlikely that the hyperdiploid metaphases (12%) found were caused by this mechanism. Furthermore, we found 41% of the hyperdiploid metaphases involved an additional F chromosomea pattern reported by others (8,20). Therefore, it is reasonable to conclude that the hyperdiploid metaphases, especially those with an additional F chromosome seen before the bone marrow transplantation, represent acute leukemic cells.…”

Section: Discussionsupporting

confidence: 76%

In vivo leukemic transformation: Cytogenetic evidence of in vivo leukemic transformation of engrafted marrow cells

Goh

Klemperer

1977

American J Hematol

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A 4-year-old girl with acute myeloblastic leukemia was treated with 50 mg/kg cyclophosphamide daily for 4 days before being given 1.7 X 10(8) bone marrow cells/kg from her HL-A identical, MLC nonreactive, cytogenetically normal brother. The patient died 92 weeks after the marrow graft. Postmortem examination showed increased myeloblasts and promyelocytes. Cytogenetic studies before transplantation showed that all sex determination metaphases had an XX pattern, and 41% of the hyperdiploid metaphases had an additional 19-20(F) chromosome. At autopsy all hyperdiploid metaphases with XY pattern and 43% of the hyperdiploid metaphases with an XX pattern had an additional F chromosome. Occasional metaphases with 47, XX, + F or 47, XY, + F were seen during the follow-up studies. These findings indicated that an acute leukemia had developed in the XY cell line of this artifically induced sex chimeric child. This suggests that a leukemic stimulus other than that proposed to be induced by total-body irradiation existed in this patient and transformed the engrafted cells.

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Section: Discussionsupporting

confidence: 76%

In vivo leukemic transformation: Cytogenetic evidence of in vivo leukemic transformation of engrafted marrow cells

Goh

Klemperer

1977

American J Hematol

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“…Bone marrow cells were used for chromosome analysis. Methods for chromosome preparation and the demonstration of G-bands have been described previously (Hossfeld, 1974). To obtain R-bands Scheres' method (Scheres, 1976) was employed.…”

Section: Methodsmentioning

confidence: 99%

New Translocations in Chronic Granulocytic Leukaemia: t(X;22) (p22;q11) and t(15;22) (q26;q11)

Hossfeld¹,

Köhler²

1979

Br J Haematol

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Two cases of Ph1-positive chronic granulocytic leukaemia with hitherto undescribed translocations are presented. In case 1 the deleted part of chromosome number 22q- was translocated to the short arm of the X chromosome, t(X;22)(p22;q11). Pronounced basophilia, trisomy 19 in the majority of metaphases, and a partial cytogenetic normalization of the bone marrow during busulphan induced remission were additional remarkable features of this case. In case 2 a translocation t(15;22)(q26;q11) was found. In this case the disease was characterized by an increase of unusually small megakaryocytes, thrombocytosis, and an accelerated course.

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“…Chromosome preparations were made 2 h after the cells had been obtained from the patients. Techniques to achieve G-and C-banding have been described previously (Hossfeld, 1974).…”

Section: Cytologically and Histologically The Effusions Ofmentioning

confidence: 99%

Chromosome findings in effusions from patients with Hodgkin's disease

Hossfeld¹,

Schmidt²

1978

Intl Journal of Cancer

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Effusion cells from six patients with advanced Hodgkin's disease were studied. Even though no Hodgkin or Reed-Sternberg cells could be identified cytologically in five of the six cases, striking chromosome anomalies of a clonal nature, including a number of recurrent marker chromosomes, were demonstrated in all effusions. It is concluded that the effusion cells with abnormal karyotypes were intimately related to the pathogenesis of Hodgkin's disease.

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Identification of chromosome anomalies in the blastic phase of chronic myelocytic leukemia (CML) by Giemsa- and quinacrine-banding techniques

Cited by 18 publications

References 11 publications

In vivo leukemic transformation: Cytogenetic evidence of in vivo leukemic transformation of engrafted marrow cells

In vivo leukemic transformation: Cytogenetic evidence of in vivo leukemic transformation of engrafted marrow cells

New Translocations in Chronic Granulocytic Leukaemia: t(X;22) (p22;q11) and t(15;22) (q26;q11)

Chromosome findings in effusions from patients with Hodgkin's disease

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