Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening

One-pot, four-component synthesis of pyrano[2,3-c]pyrazoles catalyzed by sodium benzoate in aqueous medium

“…Compounds bearing pyranopyrazole system have been found to have various biological activities, for instance antimicrobial, 1 analgesic, 2 vasodilator, 3 anticancer, 4,5 antiinflammatory, 6 inhibitors of human Chk1 kinase, 7 molluscicidal, 8 antifungicidal, 9 and also as biodegradable agrochemicals, 10 Furthermore, some of these compounds are commonly in employment such as cosmetics and pigments.…”

An Efficient and Green Protocol for the Synthesis of Dihydropyrano [2,3-C] Pyrazoles in Aqueous Medium Using Thiamine Hydrochloride as a Catalyst

“…The pyranopyrazoles have been reported to exhibit interesting biological properties such as antimicrobial, 5 analgesic, 6 antiinflammatory, 7 insecticidal 8 and molluscicidal 9 and also serve as potential inhibitors of human Chk1 kinase. 10 As consequence, synthesis of these important pharmacophore attracted more attention of pharmaceutical industry and organic chemists.…”

Glycerol mediated, one pot, multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles

“…Pyrano [2,3-c]pyrazole derivatives show many bioactivities such as antimicrobial [32], insecticidal [33], anti-inflammatory activities [34] and molluscicidal activity [35,36]. Pyrano [2,3-c]pyrazoles are known have application in screening kit for Chk1 kinase inhibitor [37,38] and also used as photoactive material [39].…”