Identification of Chemical Compounds in Ziziphus mauritiana Fruit Juice by GC-MS and LC-MS/MS Analysis

Soraya, Syafira; Sukara, Endang; Sinaga, Ernawati

doi:10.32996/ijbpcs.2022.4.2.2

Cited by 5 publications

(8 citation statements)

References 12 publications

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“…The chromatography–mass spectrometry (GC–MS) analysis of blackberry juice was performed following a published procedure (Soraya et al 2022 ). A thermal scientific trace GC Ultra/ISQ single Quadrupole MS, TG-5MS fused silica capillary column was utilized for the GC/MS analysis at the National Research Center, Dokki, Giza (30 m, 0.251 mm, and 0.1 mm film thickness).…”

Section: Methodsmentioning

confidence: 99%

Effect of anthocyanin-rich blackberry juice on endoplasmic reticulum stress in streptozotocin-induced diabetic rats

Tony

Hassan

Ismail

et al. 2023

Environ Sci Pollut Res

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This study investigates blackberry juice’s effects on glucose metabolism, oxidative stress, inflammation, and endoplasmic reticulum stress (ER) in streptozotocin (STZ)-induced diabetic rats. Fifty Wistar rats were distributed to five groups randomly of ten rats each: Normal control, diabetic control, 9 mL/kg body weight (b.wt) blackberry juice only, blackberry juice plus diabetes, and 500 mg/kg b.wt metformin plus diabetes. A single intraperitoneal injection of 50 mg/kg b.wt STZ induced diabetes in the rats. This animal study continued for 56 days after the confirmation of diabetes. The levels of liver function and renal function, as well as insulin, glucose-6-phosphatase, glucokinase, and malondialdehyde (MDA) levels, and the activities of catalase (CAT) and superoxide dismutase (SOD), were determined. Additionally, interleukin-6 (IL-6) levels, tumor necrosis factor-alpha (TNF-α), and activated transcription factor 4 (ATF4) expressions were examined in the liver homogenate of rats. Furthermore, the liver tissues were utilized for histopathological examination. The results showed that blackberry juice prevented drastic loss of body weight and reduced food consumption in diabetic rats. Additionally, the levels of blood glucose, total protein, aspartate aminotransferase (AST), albumin, alanine aminotransferase (ALT), uric acid, creatinine, and urea improved after the administration of blackberry juice in diabetic rats. Blackberry juice significantly increased glucose metabolism and antioxidant status while reducing ER stress and inflammation in diabetic rats. Moreover, blackberry juice improved glucose metabolism by increasing insulin levels and improving the dysregulated activities of glucose-metabolizing enzymes. The microstructure of liver tissues in diabetic rats was also improved with blackberry juice treatment. Therefore, blackberry juice has the potential to alleviate diabetes in rats and could be considered as a functional food for people with diabetes.

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Section: Methodsmentioning

confidence: 99%

Effect of anthocyanin-rich blackberry juice on endoplasmic reticulum stress in streptozotocin-induced diabetic rats

Tony

Hassan

Ismail

et al. 2023

Environ Sci Pollut Res

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“… Plant part Active constituents Compound class Structure Activity Fruit Magnoflorine( Soraya et al, 2022 ) Alkaloid Anti-diabetic, anti-inflammatory,neuropsychopharmacology, immunomodulatory, hypotensive, & antifungal activities ( Xu et al, 2020 ). Nortropanoline( Soraya et al, 2022 ) Alkaloid Anti-diabetic, anticancer, & antiviral activity( Underlin and Jensen, 2019 ). Zizyberenalic acid( Karim et al, 2019 ) Pentacyclic triterpenoid Cytotoxic activity( Lee et al, 2003 ).…”

Section: Nutraceutical Propertiesmentioning

confidence: 99%

“… D-Allose( Kushwaha et a., 2019 ) Aldohexose sugar Immunosuppressant on allogenic orthotopic liver transplantation( Hirooka et al, 2006 ),Anti-cancerous( Mitani et al, 2009 ),Suppresses ROS production in the mitochondria( Ishihara et al, 2011 ),Neuroprotective effects( Liu et al, 2014 ). Naringenin( Memon et al, 2012 ) Flavonoid Antioxidant, antitumor, antibacterial, anti-inflammatory( Salehi et al, 2019 ) Quercetin 3′-O-glucoside( Memon et al, 2013 ) Flavonoid Antidiabetic and antioxidative effects( Panda & Kar, 2007 ) Rutin( Yahia et al, 2020 ) Flavonoid glycoside Antioxidant, and cardio protective activities( Ganeshpurkar and Saluja, 2017 ) Quinic acid( Soraya et al, 2022 ) Phenol Antioxidant and analgesic effects( Benali et al, 2022 ) Hexadecanoic acid( Soraya et al, 2022 ) Long-chain fatty acid Antioxidant, antimicrobial, anti-inflammatory hypocholesterolemia, Nematicide,&Antiandrogenic ( Sheela, &Uthayakumari, 2013 ) Seed Ceanothic acid( Guo et al, 2014 ) Triterpenoid Cytotoxic effect( Lee et al, 1998 ) Betulinic acid( Guo et al, 2014 ) Pentacyclictriterpenoid Anti-HIV, anti-bacterial, anti-malarial, and anticancer activities ( Moghaddam et al, 2012 ) Rutin( Yahia et al, 2020 ) Flavonoid glycoside suppress phosphodiesterase, which may be essential for smooth muscle relaxations. ( …”

Section: Nutraceutical Propertiesmentioning

confidence: 99%

Indian jujube a potential fruit tree to improve the livelihood

Sishu

Das

Selvaraj

2023

Saudi Journal of Biological Sciences

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“…Z. mauritiana is an upright tree with small thorns attached to tree branches and leaf gaps. The leaves are slightly oval in shape and green in color (Sodimu et al, 2020;Soraya et al, 2022). Although edible, Z. mauritiana fruits do not have high economic value in Indonesia.…”

Section: Introductionmentioning

confidence: 99%

Total Phenolic and Total Flavonoid Content, Antioxidant Activity, and Nutritional Profile of Ziziphus mauritiana Fruit Juice

Adilah

Saleh

Az-Zahra

et al. 2023

IJBPCS

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Ziziphus mauritiana is a plant species belonging to the Rhamnaceae family. It is commonly found in tropical and subtropical regions of Asia, and in Indonesia, this plant grows wild and thrives on the islands of Bali, Lombok and Sumbawa. The fruits of Z. mauritiana are edible, however, in Indonesia, it is underutilized and has very low economic value. To evaluate its possibility to be developed as a functional food, this study was conducted to determine the total phenolics and flavonoids, dietary fiber, and nutrients contained in the fruit juice of Ziziphus mauritiana. Total phenols and flavonoids contents were determined using Folin Ciocalteu and AlCl3 methods, respectively. The in vitro antioxidant activity of the juice was evaluated using the DPPH method. The content of soluble and insoluble dietary fiber was determined using the standard AOAC analysis method, and proximates analysis was conducted in accordance with SNI 01-2891-1992. The results of this study revealed that freeze-dried juice of Z. mauritiana fruit has total phenols content of 1690 mg GAE/100g, total flavonoids of 15.10 mg QE/100g, soluble dietary fiber of 0.61%, and insoluble dietary fiber 2.03%. However, the antioxidant activity of Ziziphus mauritiana fruit juice was weak with IC50 328.54 ppm. The proximate analysis revealed the crude fiber in the freeze-dried fruit juice was 0.56%, carbohydrates 82.43%, protein 3.34%, fats 0.31%, ash 3.62%, and water 10.30%. In conclusion, Ziziphus mauritiana fruit juice has a high content of total phenolic substances, high dietary fiber, and high nutritional value, therefore it has a good potential to be developed as a functional food.

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Identification of Chemical Compounds in Ziziphus mauritiana Fruit Juice by GC-MS and LC-MS/MS Analysis

Cited by 5 publications

References 12 publications

Effect of anthocyanin-rich blackberry juice on endoplasmic reticulum stress in streptozotocin-induced diabetic rats

Effect of anthocyanin-rich blackberry juice on endoplasmic reticulum stress in streptozotocin-induced diabetic rats

Indian jujube a potential fruit tree to improve the livelihood

Total Phenolic and Total Flavonoid Content, Antioxidant Activity, and Nutritional Profile of Ziziphus mauritiana Fruit Juice

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