Identification of central amygdala and trigeminal motor nucleus connectivity in humans: An <scp>ultra‐high</scp> field diffusion <scp>MRI</scp> study

Kaya, Batu; Geha, Paul; Araújo, Ivan de; Cioffi, Iacopo; Moayedi, Massieh

doi:10.1002/hbm.26104

Cited by 6 publications

(5 citation statements)

References 52 publications

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“…Studies in mice have revealed that a direct projection from CeA to trigeminal motor nucleus is highly activated during hunting of prey and that it promotes strong biting attacks (43). Of note, the same pathway has recently been identified in humans, and in higher distribution than BLA-Mo5 (Trigeminal Motor Nucleus) (44), further highlighting that the same association may also apply to humans and warranting further research in this field. Fig.…”

Section: Nutrient Insufficiencies and Deficiencies Involved In The Pa...mentioning

confidence: 84%

Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review)

Pavlou,

Spandidos,

Zoumpourlis

et al. 2023

Exp Ther Med

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Stress has been well-documented to have a significant role in the etiopathogenesis of bruxism. Activation of the hypothalamic-pituitary-adrenal axis (HPA) and subsequent release of corticosteroids lead to increased muscle activity. Neurological studies have demonstrated that chronic stress exposure induces neurodegeneration of important neuronal structures and destabilization of the mesocortical dopaminergic pathway. These disruptions impair the abilities to counteract the overactivity of the HPA axis and disinhibit involuntary muscle activity, while at the same time, there is activation of the amygdala. Recent evidence shows that overactivation of the amygdala under stressful stimuli causes rhythmic jaw muscle activity by over activating the mesencephalic and motor trigeminal nuclei. The present review aimed to discuss the negative effects of certain vitamin and mineral deficiencies, such as vitamin D, magnesium, and omega-3 fatty acids, on the central nervous system. It provides evidence on how such insufficiencies may increase stress sensitivity and neuromuscular excitability and thereby reduce the ability to effectively respond to the overactivation of the sympathetic nervous system, and also how stress can in turn lead to these insufficiencies. Finally, the positive effects of individualized supplementation are discussed in the context of diminishing anxiety and oxidative stress, neuroprotection and in the reversal of neurodegeneration, and also in alleviating/reducing neuromuscular symptoms.

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Section: Nutrient Insufficiencies and Deficiencies Involved In The Pa...mentioning

confidence: 84%

Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review)

Pavlou,

Spandidos,

Zoumpourlis

et al. 2023

Exp Ther Med

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“…There have been reports of direct projections from the central nucleus of the amygdala to the Me5, which are crucial for the perception and control of negative emotions (69). This type of projection has been connected to stronger biting attacks during hunting in animal studies and has recently been identified in humans as well (70,71).…”

Section: Implication Of the Mesocortical Dopaminergic Pathway In Bruxismmentioning

confidence: 95%

Neurobiology of bruxism: The impact of stress (Review)

Pavlou,

Spandidos,

Zoumpourlis

et al. 2024

Biomed Rep

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Bruxism is a non-functional involuntary muscle activity that affects more than one-third of the population at some point in their lives. A number of factors have been found to be related to the etiopathogenesis of bruxism; therefore, the condition is considered multifactorial. The most commonly accepted factor is stress. Stress has long been considered to increase muscle tone and to reduce the pain threshold. Current evidence indicates that exposure to chronic stress, distress and allostatic load ignite neurological degeneration and the attenuation of critical neuronal pathways that are highly implicated in the orofacial involuntary muscle activity. The present review discusses the negative effects that chronic stress exerts on certain parts of the central nervous system and the mechanisms through which these changes are involved in the etiopathogenesis of bruxism. The extent of these morphological and functional changes on nerves and neuronal tracts provides valuable insight into the obstacles that need to be overcome in order to achieve successful treatment. Additionally, particular emphasis is given on the effects of bruxism on the central nervous system, particularly the activation of the hypothalamic-pituitary-adrenal axis, as this subsequently induces an increase in circulating corticosterone levels, also evidenced by increased levels of salivary cortisol, thereby transforming bruxism into a self-reinforcing loop.

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“…Han et al 75 showed that a brain circuit connecting CeA to the trigeminal motor nucleus (5 M) controls the muscles of mastication during prey hunting in rodents. Of note, this circuit has also been recently delineated in human MRIs 76 . As CeA is a crucial regulatory hub for anxiety, it is possible that amygdala plays a key role in modulating jaw motor function and may be implicated in the neural pathways leading to bruxism‐like behaviours as a stress response.…”

Section: Psychological States and Traits Affect Sensory Processingmentioning

confidence: 97%

“…Of note, this circuit has also been recently delineated in human MRIs. 76 As CeA is a crucial regulatory hub for anxiety, it is possible that amygdala plays a key role in modulating jaw motor function and may be implicated in the neural pathways leading to bruxism-like behaviours as a stress response. However, further studies are needed to answer this research question.…”

Section: Instrument Domains Descriptionmentioning

confidence: 99%

Biological and psychological factors affecting the sensory and jaw motor responses to orthodontic tooth movement

Cioffi

2023

Orthod Craniofacial Res

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Orthodontic tooth movement (OTM) is associated with an inflammatory response, tooth pain (i.e. orthodontic pain) and changes in dental occlusion. Clinical realms and research evidence suggest that the sensory and jaw motor responses to OTM vary significantly among individuals. While some adjust well to orthodontic procedures, others may not and can experience significant pain or not adjust to occlusal changes. This is of concern, as clinicians cannot anticipate an individual's sensorimotor response to OTM. Converging evidence shows that some psychological states and traits significantly affect the sensorimotor response to OTM and may considerably affect an individual's adaptation to orthodontic or other dental procedures. We performed a topical review to synthesize the available knowledge about the behavioural mechanisms regulating the sensorimotor response to OTM, with the intent of informing orthodontic practitioners and researchers about specific psychological states and traits that should be considered while planning orthodontic treatment. We report on studies focusing on the role of anxiety, pain catastrophising, and somatosensory amplification (i.e. bodily hypervigilance), on sensory and jaw motor responses. Psychological states and traits can significantly affect sensory and jaw motor responses and a patient's adaptation to orthodontic procedures, although large interindividual variability exists. Clinicians can use validated instruments (checklists or questionnaires) to collect information about patients' psychological traits, which can assist in identifying those individuals who may not adjust well to orthodontic procedures. The information included in this manuscript also assists researchers investigating the effect of orthodontic procedures and or/appliances on orthodontic pain.

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Identification of central amygdala and trigeminal motor nucleus connectivity in humans: An ultra‐high field diffusion MRI study

Cited by 6 publications

References 52 publications

Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review)

Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review)

Neurobiology of bruxism: The impact of stress (Review)

Biological and psychological factors affecting the sensory and jaw motor responses to orthodontic tooth movement

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