Identification of Cells Expressing IL-17A and IL-17F in the Lungs of Patients With COPD

Cigarette smoke affects IL-17A, IL-17F and IL-17 receptor expression in the lung tissue: Ex vivo and in vitro studies

“…It has been reported that IL-17A levels are increased in submucosal biopsy specimens from the large airways of patients with COPD compared with control subjects, but there is no difference for IL-17F [13] or in contrast that both IL-17A and IL-17F positive cells were higher in bronchial biopsies from COPD patients than in healthy control [14]. Furthermore, it was observed that the levels of IL-17A are increased in the submucosa of lung tissue from COPD than in S and HC while there were not differences in the subepithelium [15]. However, no findings clarify the role of IL-17 immunity in central or distal airway of COPD suggesting the necessity to compare the levels IL-17A, IL-17F and the related receptor (IL-17R) in the two lung districts.…”

“…Results were expressed as the number of positive epithelial cells/mm basement membrane as previously described [19]. Finally, immunostained cells were quantified in the subepithelium of central and distal airway, and the results were expressed as the number of positive cell/mm 2 [15,13].…”

Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer

“…[21][22][23] A number of publications on chronic inflammatory and auto-immune disorders have reported that neutrophils and mast cells are the predominant source of IL-17. [23][24][25] To elucidate the localization and phenotype of IL-17 expressing cells, we performed an extensive analysis of the cell types that express IL-17 in cervical cancer. Subsequently, we investigated the distribution of the main IL-17 expressing cell populations in head and neck, ovarian, endometrial, prostate, breast, lung, and colon cancer.…”

A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry

“…While a number of recent reports have proposed that neutrophils are a source of IL-17 in inflammatory and infectious diseases in both mouse and humans [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], the ability of human neutrophils to express IL-17A is controversial [21].…”