Identification of CD8 T-cell dysfunction associated with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID and treatment with a nebulized antioxidant/anti-pathogen agent in a retrospective case series

Gil, Anna; Hoag, George E.; Salerno, John P.; Hornig, Mady; Klimas, Nancy; Selin, Liisa K.

doi:10.1016/j.bbih.2023.100720

Cited by 2 publications

(2 citation statements)

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“…В проспективных исследованиях у 5-13% людей, инфицированных определенными патогенами, СХУ развился в последующие месяцы [55]. Не было обнаружено ни одного специфического возбудителя при СХУ, хотя некоторые инфекционные агенты, такие как вирус Эпштейна -Барра и другие вирусы герпеса, в дополнение к энтеровирусам, чаще рассматривались в качестве потенциальных триггеров СХУ [56]. Учитывая пандемию COVID-19, есть основания для беспокойства по поводу того, что рост распространенности СХУ может быть одним из последствий коронавирусного поражения.…”

Section: синдром хронической усталостиunclassified

Mental fatigue and chronic fatigue syndrome in clinical practice

Pizova,

Pizov

2024

Medicinskij sovet

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Fatigue is an extremely disabling symptom both in healthy people and in various diseases. Physical fatigue is characterized by limitations in physical functioning, while mental/cognitive fatigue involves difficulties in concentrating and performing cognitive tasks. Mental and physical fatigue exist in both pathological and physiological fatigue. Fatigue is primarily an adaptive physiological process. It is a signal to have a rest and helps conserve energy to prevent injury, which can be useful after intense work, or when the body’s defenses need to be redistributed, for example, during infectious disease. It is important to distinguish between fatigue or tiredness and chronic fatigue syndrome in clinical practice. Chronic fatigue syndrome has multisystem manifestations and affects millions of people globally. Although the exact aetiology of chronic fatigue syndrome is uncertain, the studies point to neurological, immunological, autonomic and energy disorders. The main sings of chronic fatigue syndrome are debilitating fatigue that is worsened by activity, poor exercise tolerance, unrefreshing sleep and cognitive impairment. Reduced information processing speed is the most common cognitive impairment in chronic fatigue syndrome. Other manifestations include decreased reaction time, working memory, and attention. These symptoms must persist for at least 3–6 months for a diagnosis to be made. As there are no specific tests for chronic fatigue syndrome, a diagnosis can be established on the basis of a medical history and physical examination.Although there are no standards-based methods specific to chronic fatigue syndrome, clinicians can reduce the severity of symptoms using pharmacological and non-pharmacological treatment approaches that have proved their efficacy in clinical practice. In particular, nootropics are widely used in asthenic conditions and chronic fatigue syndrome. Fonturacetam is a nootropic drug that directly activates brain integration activities, promotes memory consolidation, and improves concentration and mental activity.

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Section: синдром хронической усталостиunclassified

Mental fatigue and chronic fatigue syndrome in clinical practice

Pizova,

Pizov

2024

Medicinskij sovet

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“…Due to the enormous complexity of CFS, its pathogenesis is still unclear. Some of the researchers suggest immunological, neuroendocrine and metabolic pathways that causes CFS, which indicates significant immune dysregulation ( 7 , 8 ). Neuroendocrine mechanisms have been the focus of some research.…”

Section: Introductionmentioning

confidence: 99%

Research progress in the treatment of chronic fatigue syndrome through interventions targeting the hypothalamus-pituitary-adrenal axis

Zhang,

Wang

2024

Front. Endocrinol.

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Chronic fatigue syndrome (CFS) causes great harm to individuals and society. Elucidating the pathogenesis of CFS and developing safe and effective treatments are urgently needed. This paper reviews the functional changes in the hypothalamus-pituitary-adrenal (HPA) axis in patients with CFS and the associated neuroendocrine mechanisms. Despite some controversy, the current mainstream research evidence indicates that CFS patients have mild hypocortisolism, weakened daily variation in cortisol, a weakened response to the HPA axis, and an increase in negative feedback of the HPA axis. The relationship between dysfunction of the HPA axis and the typical symptoms of CFS are discussed, and the current treatment methods are reviewed.

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Identification of CD8 T-cell dysfunction associated with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID and treatment with a nebulized antioxidant/anti-pathogen agent in a retrospective case series

Cited by 2 publications

References 129 publications

Mental fatigue and chronic fatigue syndrome in clinical practice

Mental fatigue and chronic fatigue syndrome in clinical practice

Research progress in the treatment of chronic fatigue syndrome through interventions targeting the hypothalamus-pituitary-adrenal axis

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