2023
DOI: 10.3390/ijms24065331
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Identification of CD114 Membrane Receptors as a Molecular Target in Medulloblastomas

Abstract: Medulloblastomas are the most common solid tumors in children, accounting for 8–30% of pediatric brain cancers. It is a high-grade tumor with aggressive behavior and a typically b poor prognosis. Its treatment includes surgery, chemotherapy, and radiotherapy, and presents high morbidity. Significant clinical, genetic, and prognostic differences exist between its four molecular subgroups: WNT, SHH, Group 3, and Group 4. Many studies seek to develop new chemotherapeutic agents for medulloblastomas through the id… Show more

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Cited by 2 publications
(5 citation statements)
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“…Recombinant human GCSF is clinically used to prevent neutropenia, due to its effects on neutrophil mobilization and maturation [ 32 ]. GCSF/CD114 signaling has also been investigated as a modulator of neuronal survival, synaptic plasticity [ 6 , 28 , 29 , 30 , 31 ], and cancer [ 7 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Specifically, CD114 has been put forward as a marker to identify CSC subpopulations associated with tumorigenicity, metastasis, and resistance to treatment [ 7 , 9 , 10 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Recombinant human GCSF is clinically used to prevent neutropenia, due to its effects on neutrophil mobilization and maturation [ 32 ]. GCSF/CD114 signaling has also been investigated as a modulator of neuronal survival, synaptic plasticity [ 6 , 28 , 29 , 30 , 31 ], and cancer [ 7 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Specifically, CD114 has been put forward as a marker to identify CSC subpopulations associated with tumorigenicity, metastasis, and resistance to treatment [ 7 , 9 , 10 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, no association between the protein expression of CD114 and patient mortality was found [ 13 ]. Similarly, different levels of CSF3R transcripts occur among different tumor subgroups and subtypes of MB, but no significant association with patient survival was established [ 18 ]. A previous study in glioma analyzed the RNA and protein expression of GCSF and CD114 in a set of 22 human gliomas (WHO grade II, III, and IV) and cell cultures derived from these tumors.…”
Section: Discussionmentioning
confidence: 99%
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“…They differ in many aspects from the disease in adults, both in site (pediatric brain tumors are more often infratentorial [#60% of cases]) and in histology (50), as has been recognized in the most recent WHO classification of CNS tumors (fifth edition, 2021), in which specific pediatric variants have been added (e.g., pediatric-type low-grade and highgrade diffuse gliomas) (51)(52)(53). Recent advances in molecular and genetic characterization have detected many peculiarities of pediatric CNS tumors, significantly impacting spreading, response to treatment, and survival (54,55).…”
Section: Contextmentioning
confidence: 99%