Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis

Kaniwa, Masa-aki; Isama, Kazuo; Nakamura, Akitada; Kantoh, Hiromi; Hosono, Kumiko; Itoh, Masatoshi; Shibata, Keiko; Usuda, Toshikazu; Asahi, Kunihiko; Osada, Tomoko; Matsunaga, Kayoko; Ueda, Hiroshi

doi:10.1111/j.1600-0536.1994.tb00723.x

Cited by 42 publications

(11 citation statements)

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“…Sometimes they combine the chromatography and patch tests to investigate the possible causes of allergic contact dermatitis. 15 Some researchers advise that when an individual is suspected of having contact dermatitis caused by rubber additives, but the patch test with a standard battery of patches is negative, thiourea may be the suspected allergen. 16,17 A study of this population showed that this group presents a higher incidence of stomach and upper aerodigestive tract cancers when compared with the unexposed population.…”

Section: Discussionmentioning

confidence: 99%

Fundamentos sobre o conhecimento dos aditivos químicos presentes nas luvas de borracha

Oliveira¹,

Alchorne

2011

An. Bras. Dermatol.

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BACKGROUNDS: One of the most frequent causes of allergic contact dermatitis of occupational origin are rubber additives, which are present in Personal Protective Equipment (PPE). The most allergenic additives of natural and synthetic gloves are thiurams, carbamates and mercapto group. OBJECTIVE: To investigate the state of knowledge about the chemical additives used in the manufacture of synthetic rubber gloves. METHODS: This was a qualitative research study in which professionals working in the manufacture, research, prescription and commercialization of gloves answered an open questionnaire. RESULTS: 30 individuals were interviewed: 4 researchers in occupational medicine, 5 occupational physicians, 2 occupational safety technicians, a rubber workers' union physician, an occupational safety engineer, a pro duction engineer of rubber gloves, 4 importers of gloves, a manufacturer of gloves, 3 businessmen who sell PPE, 3 salesclerks working in stores that sell PPE, 2 businessmen who own stores that sell products for allergic individuals, and 3 dermatologists. CONCLUSION: Knowledge of the chemical composition of rubber gloves is scant. The labeling of gloves, with the description of their chemical composition, would facilitate choosing the best type of glove for each person. This low-cost action to businesses would be a gain from the standpoint of public health, with huge repercussions for users of rubber gloves. Keywords: Allergy and immunology; Dermatitis, allergic contact; Dermatitis, contact; Dermatitis, occupational; Gloves, protective; Rubber Resumo: FUNDAMENTOS: Uma das causas mais frequentes de dermatite de contato alérgica, de origem ocupacional, são os aditivos da borracha, presentes nos Equipamentos de Proteção Individual. Os aditivos das luvas natural e sintética mais alergênicos são tiurams, mercaptos e carbamatos. OBJETIVO: levantar o nível de conhecimento em relação aos aditivos químicos utilizados na fabricação das luvas de borracha sintética. MÉTODOS: Foi aplicado um questionário aberto a profissionais que trabalham com fabricação, pesquisa, prescrição e comercialização das luvas. Foi adotado o método de pesquisa qualitativa. RESULTADOS: Foram entrevistadas 30 pessoas: 4 pesquisadores na área de Medicina do Trabalho, 5 médicos do Trabalho, 2 técnicos de segurança do Trabalho, 1 médico do sindicato de trabalhadores da borracha, 1 engenheiro de Segurança do Trabalho, 1 engenheira de Produção do setor de fabricação de luvas de borracha, 4 empresários importadores de luvas, 1 empresário fabricante de luvas, 3 empresários que comercializavam Equipamentos de Proteção Individual, 3 vendedores de lojas de Equipamentos de Proteção Individual, 2 empresários de lojas que comercializavam produtos para alérgicos e 3 dermatologistas. CONCLUSÃO: O conhecimento da composição química das luvas é pequeno. A rotulagem das luvas, com a descrição da composição química, facilitaria a escolha do melhor tipo de luva para cada pessoa. Esta ação, de baixo custo para as empresas, seria um ganho, do ponto de vista d...

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Section: Discussionmentioning

confidence: 99%

Fundamentos sobre o conhecimento dos aditivos químicos presentes nas luvas de borracha

Oliveira¹,

Alchorne

2011

An. Bras. Dermatol.

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“…2 Kaniwa and colleagues believe that patch testing and chemical analysis should be combined to confirm the relevance of positive patch-test reactions and to discover new allergens. 9 Accordingly, Bruze and colleagues suggested performing patch tests with the components revealed by thin-layer chromatography (TLC) in order to confirm probable sensitization. 10 …”

Section: T He Incidence Of Sensitization To Rubbermentioning

confidence: 99%

Occupational Allergic Contact Dermatitis from Antioxidant Amines in a Dental Technician

Condé‐Salazar¹,

Valks²,

Acebes³

et al. 2004

Dermatitis

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We describe an 18-year-old dental technician who presented with dry hyperkeratotic lesions on his left palm that were limited to an area that was in contact with a container in which he had prepared the molds for a dental prosthesis. On patch testing, he had a positive reaction to black rubber mix and its components N-cyclohexyl-NV-phenyl-4-phenylenediamine, N,NV-diphenyl-4-phenylenediamine, and N-isopropyl-NV-phenyl-4-phenylenediamine, as well as to a piece of the rubber container. Thin-layer chromatography (TLC) of a piece of the rubber container confirmed the presence of the para-phenylenediamine mix. Results of patch-testing with TLC were positive after 48 and 96 hours. The lesions resolved when the patient stopped using the container. The patient was diagnosed with occupational allergic contact dermatitis. We also review the dermatoses caused by antioxidant amines.

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“…Moreover, these compounds are also used as fungicides. Liquid chromatography (LC) is the method most commonly used for analysis of DTC [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. However, some metal-DTC complexes (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, Zn DTC analysis failed. Some authors [2,5,9,10,13], have proposed a precolumn derivatization of Zn DTC compounds, resulting in a more stable complex (e.g. Co or Ni DTC) suitable for reversed-phase LC (RPLC).…”

Section: Introductionmentioning

confidence: 99%

Liquid Chromatography of Unstable Zinc Dithiocarbamates. Application to Rubber Gloves Analysis

Mathieu

Herbreteau

Lafosse

et al. 2000

J. High Resol. Chromatogr.

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Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis

Cited by 42 publications

References 11 publications

Fundamentos sobre o conhecimento dos aditivos químicos presentes nas luvas de borracha

Fundamentos sobre o conhecimento dos aditivos químicos presentes nas luvas de borracha

Occupational Allergic Contact Dermatitis from Antioxidant Amines in a Dental Technician

Liquid Chromatography of Unstable Zinc Dithiocarbamates. Application to Rubber Gloves Analysis

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