Identification of catecholaminergic inputs to and outputs from aromatase-containing brain areas of the Japanese quail by tract tracing combined with tyrosine hydroxylase immunocytochemistry

Balthazart, Jacques; Absil, Philippe

doi:10.1002/(sici)1096-9861(19970609)382:3<401::aid-cne7>3.0.co;2-7

Cited by 106 publications

(70 citation statements)

References 97 publications

(138 reference statements)

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“…In addition to the A14 input, all midbrain DA populations are also known to project to the medial POA, at least in quail where this issue has been most thoroughly examined (Balthazart and Absil, 1997). These projections include approximately equivalent contributions from the A8 and A10 cell groups, a somewhat lighter projection from the A11 cell group, and a small projection from the A9 neurons.…”

Section: Discussionmentioning

confidence: 99%

“…However, anatomical studies on this point are limited, and no systematic retrograde tracings have been conducted from the POA in conjunction with immunocytochemical labeling of dopaminergic neurons. To date, the only species for which such data are available is the Japanese quail (Balthazart and Absil, 1997). DA inputs to the POA in quail appear to arise from a variety of sources, mostly strongly from the ventromedial A14, but also from all midbrain groups (particularly the A9 and A10 populations).…”

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confidence: 99%

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Fos responses of dopamine neurons to sociosexual stimuli in male zebra finches

2006

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Dopamine (DA) is produced in numerous brain areas and influences a wide variety of social behaviors, but very few data are available to establish the socially-relevant response properties of most DA populations, which comprise eight cell groups numbered A8-A15. Anatomically, these DA populations are evolutionarily conserved, and all have been identified in both birds and mammals. We now report the Fos responses of tyrosine hydroxylase-immunoreactive (TH-ir; putatively dopaminergic) neurons in the A8-A15 cell groups of male zebra finches following exposure to a control condition or one of six different social stimuli: A heterospecific male, conspecific male, fighting in a mate competition paradigm (which includes both male and female stimuli), a courtship interaction without physical contact, a courtship interaction with physical contact but no mounting, and a courtship interaction with mounting. We found that the DA cell groups exhibit distinctive profiles of responsiveness to social stimuli. Fos induction in A8, A9, A10 and midbrain A11 neurons increased significantly in response to a variety of conspecific stimuli, but not heterospecific stimuli. In contrast, Fos induction in the preoptic A14 neurons was observed specifically in response to sexual interactions, and Fos induction in hypothalamic A11 neurons appears to primarily reflect the performance of courtship singing. Infundibular A12 neurons, which may be involved in stress-related processes, showed the highest level of TH+Fos colocalization in control subjects. This colocalization decreased in response to all conspecific stimuli except fighting, and did not decrease following exposure to a heterospecific male. Keywords dopamine; forebrain; aggression; sexual behavior; tyrosine hydroxylase; Fos Dopamine (DA) is known to influence a variety of social behaviors, particularly male sexual behavior, in multiple vertebrate groups (Warner et al., 1991;Pomerantz, 1992;Absil et al., 1994;Hull et al., 1995;Dominguez et al., 2001;Woolley et al., 2001;Melis et al., 2003;Charlier et al., 2005), and DA cells are distributed in homologous groups across the vertebrate classes (Bailhache and Balthazart, 1993;Bottjer, 1993;Gonzalez and Smeets, 1994;Reiner et al., 1994;Tillet, 1994;Appeltants et al., 2001;Adrio et al., 2002). This similarity across vertebrates is particularly clear when comparing mammals and birds, which each have dopaminergic neurons (immunopositive for tyrosine hydroxylase, TH, and immunonegative for dopamine β-hydroxylase) localized to eight populations of the basal forebrain and brainstem numbered A8 through A15 (Reiner et al., 1994;Tillet, 1994). However, it is largely unknown how these various DA populations respond to a broad range of social stimuli, so we have here examined DA neuronal responses to a variety of interactions with heterospecific and conspecific animals. Extensive data suggest that the release of DA into the preoptic area (POA) controls male sexual behavior. Administrations of the DA agonist apomorphine into the medial POA faci...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Fos responses of dopamine neurons to sociosexual stimuli in male zebra finches

2006

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“…These changes in aromatase activity can be induced by the activation of glutamate or dopamine receptors (Balthazart, Baillien, and Ball, 2002;Balthazart et al, 2003). Since glutamate and dopamine inputs and receptors are present in the preoptic area (Absil, Das, Ball, Casto, and Balthazart, 1992;Bailhache and Balthazart, 1993;Ball, Casto, and Balthazart, 1995;Balthazart and Absil, 1997;Cornil, Foidart, Minet, and Balthazart, 2000) and these receptors are expressed at the surface of aromatase cells themselves (Cornil, Seutin, Motte, and Balthazart, 2004c), it is therefore likely that afferent inputs related to a variety of environmental changes are able to rapidly affect estrogen production in the preoptic area.…”

Section: Site and Mechanisms Of Rapid Action Of Estrogensmentioning

confidence: 99%

Rapid effects of aromatase inhibition on male reproductive behaviors in Japanese quail

Cornil

Taziaux

Baillien

et al. 2006

Hormones and Behavior

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102

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Non-genomic effects of steroid hormones on cell physiology have been reported in the brain. However, relatively little is known about the behavioral significance of these actions. Male sexual behavior is activated by testosterone partly through its conversion to estradiol via the enzyme aromatase in the preoptic area (POA). Brain aromatase activity (AA) changes rapidly which might in turn be important for the rapid regulation of behavior. Here, acute effects of Vorozole ™ , an aromatase inhibitor, injected IP at different doses and times before testing (between 15 and 60 min), were assessed on male sexual behavior in quail. To limit the risk of committing both types of statistical errors (I and II), data of all experiments were entered into a meta-analysis. Vorozole ™ significantly inhibited mount attempts (p<0.05, size effect [g]=0.527) and increased the latency to first copulation (p<0.05, g=0.251). The treatment had no effect on the other measures of copulatory behavior. Vorozole ™ also inhibited appetitive sexual behavior measured by the social proximity response (p<0.05, g=0.534) or rhythmic cloacal sphincter movements (p<0.001, g=0.408). Behavioral inhibitions always reached a maximum at 30 min. Another aromatase inhibitor, androstatrienedione, induced a similar rapid inhibition of sphincter movements. Radioenzyme assays demonstrated that within 30 min Vorozole ™ had reached the POA and completely blocked AA measured in homogenates. When added to the extracellular milieu, Vorozole ™ also blocked within 5 min the AA in POA explants maintained in vitro. Together, these data demonstrate that aromatase inhibition rapidly decreases both consummatory and appetitive aspects of male sexual behavior.

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“…These cellular effects are subsequently reflected in changes in a part of the numerous projection areas of the nucleus preopticus medialis. 12,19,72 It is therefore quite possible that the involvement of the nucleus preopticus medialis in the activation of male sexual behavior does not imply the type of changes in neuronal activity that can be detected by the 2-DG autoradiographic method.…”

Section: Preoptic Areamentioning

confidence: 99%

Performance of appetitive or consummatory components of male sexual behavior is mediated by different brain areas: a 2-deoxyglucose autoradiographic study

Dermon¹,

Stamatakis²,

Tlemçani³

et al. 1999

Neuroscience

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Abstract-The in vivo autoradiographic deoxyglucose method was used to identify the functional brain circuits that are involved in the performance of appetitive and consummatory components of male sexual behavior in Japanese quail (Coturnix japonica). Two groups of castrated, testosterone-treated male quail were trained during 12 sessions to associate the view of a female behind a window with the opportunity to interact freely and to copulate with her. They developed, as a consequence, a social proximity response (staying close and looking through the window providing a view of the female) that has been used in previous experiments to measure appetitive sexual behavior. A third control group (also castrated and treated with testosterone) was allowed to view the female but not to copulate with her and therefore did not develop this proximity response. 2-14 C-deoxyglucose was then injected i.p. to these birds and they were allowed to either copulate freely with a female (consummatory sexual behavior group) or express the social proximity response (appetitive sexual behavior group). The control group was provided a view of the female but these birds, although they were exposed to the same stimuli as birds in the appetitive group, did not express the social proximity response because they had never learned the association with the opportunity to copulate. Birds were killed 45 min after the deoxyglucose injection and their brains were processed for autoradiography. Densitometric analyses of the autoradiograms revealed that the expression of appetitive or consummatory aspects of male sexual behavior was associated with significant increases by comparison with the control group in the deoxyglucose incorporation in the nucleus mesencephalicus lateralis, pars dorsalis and in the nucleus leminsci lateralis. In addition, an increase in the deoxyglucose incorporation was specifically observed in the paleostriatum primitivum, rostral preoptic area, nucleus intercollicularis, nucleus interpeduncularis and third nerve but a decrease was observed in the dorsomedial part of the hippocampus and in the nucleus nervi oculomotori in birds of the consummatory sexual behavior group by comparison with controls. By contrast, in the appetitive sexual behavior group, significant increases in deoxyglucose incorporation were observed in two telencephalic areas, the intermediate hyperstriatum ventrale and neostriatum caudolaterale by comparison with the controls, but decreases were detected in the stratum griseum et fibrosum superficiale of optic tectum by comparison with the consummatory behavior group.These studies demonstrate that the performance of appetitive or consummatory components of male sexual behavior affects in a specific manner the deoxyglucose uptake and accumulation in specific regions of the quail brain. Changes in metabolic activity were observed in steroid-sensitive areas, in auditory, visual and vocal brain regions, and in brain nuclei related to motor behavior but also in association telencephalic and limbic structures. T...

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Identification of catecholaminergic inputs to and outputs from aromatase-containing brain areas of the Japanese quail by tract tracing combined with tyrosine hydroxylase immunocytochemistry

Cited by 106 publications

References 97 publications

Fos responses of dopamine neurons to sociosexual stimuli in male zebra finches

Fos responses of dopamine neurons to sociosexual stimuli in male zebra finches

Rapid effects of aromatase inhibition on male reproductive behaviors in Japanese quail

Performance of appetitive or consummatory components of male sexual behavior is mediated by different brain areas: a 2-deoxyglucose autoradiographic study

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