Identification of carcinoma embryonic antigen release mechanism Carcinoembryonic Antigen (CEA) from the surface of colorectal cancer cells

Asadi, Shahin; M, Jamali; Mohammadzadeh, Hamideh

doi:10.15761/rri.1000109

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…The detected elevation of CEA may be caused by phospholipase enzymes that interfere with the breakdown of GPI binding and the removal of CEA from the cell surface. In addition, during colon cancer progresses, activation of oncogenic c-Ki-ras proteins causes an increase in CEA level and a disturbance of basolateral polarity 34 .…”

Section: Discussionmentioning

confidence: 99%

Expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 in patients with colorectal cancer

Hussein,

El Sewedy,

Zakareya

et al. 2023

Sci Rep

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Colorectal cancer (CRC) poses a significant burden on both the healthcare systems as well as individuals. The high mortality rate of CRC may be attributed to its metastatic potential, heterogeneity, and delayed diagnosis. CircRNAs are an essential class of regulatory RNAs that play significant roles in cancers. This study aimed to detect the expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 in patients with CRC. This study included 50 CRC patients, 30 individuals with colorectal diseases (non-cancer), and 20 healthy volunteers. By using real-time PCR, the relative expression of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 was determined in the collected blood samples. In addition, ECLIA was used to quantify carcinoembryonic antigen (CEA) level. All circRNAs expression and CEA levels were significantly up-regulated in cancer patients (CRC, colon, rectum) as compared to healthy controls, except circ-SMARCA5. Moreover, there was a significant up-regulation of circRNAs in most non-cancer patients (UC, polyp, piles). Insignificant upregulation was observed in circRNAs and CEA when comparing cancer with non-cancer patients. No correlations were found between the studied parameters and most clinicopathological characteristics of cancer and non-cancer patients. Circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 were differentially expressed in patients with CRC as well as in non-cancer patients. Circ-SMARCA5 and circ-NOL10 may act as tumor suppressors, while circ-LDLRAD3 and circ-RHOT1 may be oncogenes. Circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 could be promising markers for the early detection of CRC.

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Section: Discussionmentioning

confidence: 99%

Expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 in patients with colorectal cancer

Hussein,

El Sewedy,

Zakareya

et al. 2023

Sci Rep

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“…MOFs were also used to develop a scaffold-based biosensor to quantify carcinoembryonic antigen (CEA, a glycoprotein) [ 73 ]. CEA can be used in the clinical diagnosis of several types of cancer [ 74 ]. Guo et al.…”

Section: Scaffold-based Materials In Biosensing For Infectious Disease and Cancer Diagnosismentioning

confidence: 99%

Applications of scaffold-based advanced materials in biomedical sensing

Sarkhosh-Inanlou

Shafiei‐Irannejad

Azizi

et al. 2021

TrAC Trends in Analytical Chemistry

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There have been many efforts to synthesize advanced materials that are capable of real-time specific recognition of a molecular target, and allow the quantification of a variety of biomolecules. Scaffold materials have a porous structure, with a high surface area and their intrinsic nanocavities can accommodate cells and macromolecules. The three-dimensional structure (3D) of scaffolds serves not only as a fibrous structure for cell adhesion and growth in tissue engineering, but can also provide the controlled release of drugs and other molecules for biomedical applications. There has been a limited number of reports on the use of scaffold materials in biomedical sensing applications. This review highlights the potential of scaffold materials in the improvement of sensing platforms and summarizes the progress in the application of novel scaffold-based materials as sensor, and discusses their advantages and limitations. Furthermore, the influence of the scaffold materials on the monitoring of infectious diseases such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and bacterial infections, was reviewed.

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Identification of carcinoma embryonic antigen release mechanism Carcinoembryonic Antigen (CEA) from the surface of colorectal cancer cells

Cited by 2 publications

References 26 publications

Expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 in patients with colorectal cancer

Expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 in patients with colorectal cancer

Applications of scaffold-based advanced materials in biomedical sensing

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