Identification of capric acid as a potent vasorelaxant of human basilar arteries.

Abstract

To determine whether naturally occurring fatty acids, especially saturated ones, might act directly as vasodilators, segments of human basilar arteries and umbilical arteries were precontracted submaximally with prostaglandln F^ and then exposed to different saturated fatty acids (C4 through C16) or unsaturated fatty acids (C14 1, C18:l, C18 2, and C18:3) at concentrations from 4 fiM to 4 mM. The results showed caprate (CIO) to be the most potent vasoreiaxant and basilar arteries to be more responsive (ECJO=63 /tM) than umbilical arteries (ECJO=780 fiM). Caprate also inhibited contractions elicited by KC1, serotonin, and the thromboxane analogue U46619. The relaxation was independent of the endothelium, and potency was not related to the weak capacity of caprate to inhibit Ca T he diverse effects that saturated fatty acidshave on enzymes suggest that these acids serve physiological functions beyond that of yielding energy. These acids, for instance, uncouple phosphorylation, inhibit Na,K-ATPase, inhibit adenylate cyclase, and inhibit cytosolic guanylate cyclase but stimulate membranous guanylate cyclase. 1 -4 Moreover, each fatty acid may produce selective effects. Oleic acid more effectively inhibits Ca 2+ influx into mast cells than other Iipids and at physiological concentrations blocks 100% of an experimentally induced release of histamine.5 Among the saturated fatty acids, myristic acid was the most stimulatory of cyclic guanosine monophosphate (cGMP) production, and more so than several unsaturated ones. 3 The reasons for such stereospecificity are unknown.It is well known that the essential fatty acid arachidonate and its metabolites are vasoactive. 6 However, isolated studies suggest that other fatty acids influence vasomotion. Thus, approximately 50% of the fatty acids found in arteries are derived

Intrauterine administration of plant oils inhibits luteolysis in the mare

“…2002). In addition, capric acid is a potent vasorelaxant, as demonstrated by its ability to inhibit both PGF 2α ‐ and Ca 2+ ‐induced contractions in umbilical and basilar arteries (White et al . 1991).…”

“…Conversely, the other major fatty acid present in the fractionated coconut oil, capric acid, has one of the highest inhibitory actions of all the saturated fatty acids (C-8 to C-24) on cyclooxygenase-I (COX-I) and cyclooxgenase-II (COX-II; Henry et al 2002). In addition, capric acid is a potent vasorelaxant, as demonstrated by its ability to inhibit both PGF2a-and Ca 2+ -induced contractions in umbilical and basilar arteries (White et al 1991).…”

Two modes of fatty acid binding to bovine β‐lactoglobulin—crystallographic and spectroscopic studies

“…Capric acid in water forms anionic vesicles that could help prolong drug release in the body or have positive effect on drug uptake from digestive system (Dew et al, 2008;Maher et al, 2009). It was also postulated that capric acid could have vasorelaxant activity (White et al, 1991).…”

Wartość zdrowotna produktów kokosowych

“…Obecny w kokosie kwas kaprynowy zmniejsza napięcie naczyń krwionośnych i poprawia ich elastyczność (elastyczność tętnicy głównej osiąga nawet poziom tętnicy pępowinowej) [33,34].…”