Identification of Candidate Genes for Alcohol Preference by Expression Profiling of Congenic Rat Strains

Carr, Lucinda G.; Kimpel, Mark W.; Liang, Tiebing; McClintick, Jeanette N.; McCall, Kevin; Morse, Melissa; Edenberg, Howard J.

doi:10.1111/j.1530-0277.2007.00397.x

Cited by 37 publications

(46 citation statements)

References 48 publications

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“…With current bioinformatics tools, all possible genes underlying a QTL region can now be identified. Combined with other bioinformatics resources, each of these genes can theoretically be screened and prioritized for their potential relevance to the quantitative trait of interest, thus, providing targets for molecular-based research [28]. Therefore, the literature and bioinformactics affords an additional, complementary tool that can help demarcate a specific gene of interest from a broad QTL region with a multitude of differentially expressed genes [29].…”

Section: Candidate Gene Prioritizationmentioning

confidence: 99%

From QTL to Candidate Gene: A Genetic Approach to Alcoholism Research

Spence¹,

Liang²,

Liu³

et al. 2009

CDAR

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A major focus of research in alcohol-related disorders is to identify the genes and pathways that modulate alcohol-seeking behavior. In light of this, animal models have been established to study various aspects of alcohol dependence. The selectively bred alcohol-preferring (P) and -nonpreferring (NP) lines were developed from Wistar rats to model high and low voluntary alcohol consumption, respectively. Using inbred P and NP strains, a strong QTL (LOD-9.2) for alcohol consumption was identified on rat chromosome 4. To search for candidate genes that underlie this chromosomal region, complementary molecular-based strategies were implemented to identify genetic targets that likely contribute to the linkage signal. In an attempt to validate these genetic targets, corroborative studies have been utilized including pharmacological studies, knock-out/transgenic models as well as human association studies. Thus far, three candidate genes, neuropeptide Y (Npy), α-synuclein (Snca), and corticotrophin-releasing factor receptor 2 (Crhr2), have been identified that may account for the linkage signal. With the recent advancements in bioinformatics and molecular biology, QTL analysis combined with molecular-based strategies provides a systematic approach to identify candidate genes that contribute to various aspects of addictive behavior.

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Section: Candidate Gene Prioritizationmentioning

confidence: 99%

From QTL to Candidate Gene: A Genetic Approach to Alcoholism Research

Spence¹,

Liang²,

Liu³

et al. 2009

CDAR

Self Cite

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“…These hormones are involved in regulating reward systems, which are heavily implicated in alcohol dependence (Dai et al 2002ab;Dai et al 2005). Candidate genes for alcohol preference have national health and medic al research council | 91 australian guidelines to reduce health risks from drinking alcohol APPENDIX A1 Further issues to consider been studied in animal models and human studies suggest familial risk of alcohol dependence can be influenced by genes encoding DRD2 and ANKK1 (Bauer et al 2007;Carr et al 2007;Dick et al 2007). While the studies are of great interest it is not possible at this stage to use genetic testing as a means of identifying individuals at increased risk of alcohol dependence or alcohol-related tissue damage with the degree of accuracy that clinicians or individuals desire.…”

Section: Geneticsmentioning

confidence: 99%

Survey of alcohol-related presentations to Australasian emergency departments

et al. 2014

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Objective: To determine the proportion of alcohol‐related presentations to emergency departments (EDs) in Australia and New Zealand, at a single time point on a weekend night shift. Design, setting and participants: A point prevalence survey of ED patients either waiting to be seen or currently being seen conducted at 02:00 local time on 14 December 2013 in 106 EDs in Australia and New Zealand. Main outcome measures: The number of ED presentations that were alcohol‐related, defined using World Health Organization ICD‐10 codes. Results: At the 106 hospitals (92 Australia, 14 New Zealand) that provided data, 395 (14.3%; 95% CI, 13.0%–15.6%) of 2766 patients in EDs at the study time were presenting for alcohol‐related reasons; 13.8% (95% CI, 12.5%–15.2%) in Australia and 17.9% (95% CI, 13.9%–22.8%) in New Zealand. The distribution was skewed left, with proportions ranging from 0 to 50% and a median of 12.5%. Nine Australian hospitals and one New Zealand hospital reported that more than a third of their ED patients had alcohol‐related presentations; the Northern Territory (38.1%) and Western Australia (21.1%) reported the highest proportions of alcohol‐related presentations. Conclusions: One in seven ED presentations in Australian and New Zealand at this 02:00 snapshot were alcohol‐related, with some EDs seeing more than one in three alcohol‐related presentations. This confirms that alcohol‐related presentations to EDs are currently underreported and makes a strong case for public health initiatives.

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“…Candidate genes for preference drinking were explored in NP rats with a congenic interval containing a QTL for high preference from the P line. Several genes in several brain regions were differentially expressed (Carr et al 2007). QTL effects can also be based on differences in gene expression rather than sequence.…”

Section: Gene Expression Analysesmentioning

confidence: 99%

Neurogenetic studies of alcohol addiction

Crabbe

2008

Phil. Trans. R. Soc. B

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Neurogenetic studies of alcohol dependence have relied substantially on genetic animal models, particularly rodents. Studies of inbred strains, selectively bred lines and mutants bearing genes whose function has been targeted for over or under expression are reviewed. Studies focused on gene expression changes are the most recent contributors to this literature, and some genetic effects may work through epigenetic mechanisms. In a few instances, interesting parallels have been revealed between genetic risk in humans and studies in non-human animal models. Future approaches are likely to be increasingly complex.

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Identification of Candidate Genes for Alcohol Preference by Expression Profiling of Congenic Rat Strains

Cited by 37 publications

References 48 publications

From QTL to Candidate Gene: A Genetic Approach to Alcoholism Research

From QTL to Candidate Gene: A Genetic Approach to Alcoholism Research

Survey of alcohol-related presentations to Australasian emergency departments

Neurogenetic studies of alcohol addiction

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