Identification of c-di-AMP-Binding Proteins Using Magnetic Beads

Kampf, Jan; Gundlach, Jan; Herzberg, Christina; Treffon, Katrin; Stülke, Jörg

doi:10.1007/978-1-4939-7240-1_27

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…The supernatant was transferred into a fresh 1.5-ml reaction tube and kept on ice. The cyclic-di-AMP target fishing was performed as described (48), by passing the whole crude cell extract from WT Synechocystis sp. PCC 6803 cells growing under continuous illumination over 2′-AHC-c-diAMP agarose (catalog no.…”

Section: Pull-down Assaysmentioning

confidence: 99%

Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB

et al. 2021

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Section: Pull-down Assaysmentioning

confidence: 99%

Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB

et al. 2021

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Osmoregulation via Cyclic di-AMP Signaling

Turner

Marcellin

et al. 2020

Microbial Cyclic Di-Nucleotide Signaling

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A decade of research on the second messenger c-di-AMP

Yin

Cai

et al. 2020

FEMS Microbiology Reviews

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C-di-AMP is an emerging second messenger in bacteria and archaea that is synthesized from two molecules of ATP by diadenylate cyclases and degraded to pApA or two AMP molecules by c-di-AMP-specific phosphodiesterases. Through binding to specific protein- and riboswitch-type receptors, c-di-AMP regulates a wide variety of prokaryotic physiological functions, including maintaining the osmotic pressure, balancing central metabolism, monitoring DNA damage, and control of biofilm formation and sporulation. It mediates bacterial adaptation to a variety of environmental parameters and can also induce an immune response in host animal cells. In this review, we discuss the phylogenetic distribution of c-di-AMP-related enzymes and receptors and provide some insights into the various aspects of c-di-AMP signaling pathways based on more than a decade of research. We emphasize the key role of c-di-AMP in maintaining bacterial osmotic balance, especially in Gram-positive bacteria. In addition, we discuss the future directions and trends of the c-di-AMP regulatory network, such as the likely existence of potential c-di-AMP transporter(s), the possibility of crosstalk between c-di-AMP signaling with other regulatory systems, and the effects of c-di-AMP compartmentalization. This review aims at covering the broad spectrum of research on the regulatory functions of c-di-AMP and c-di-AMP signaling pathways.

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Identification of c-di-AMP-Binding Proteins Using Magnetic Beads

Cited by 4 publications

References 14 publications

Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB

Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB

Osmoregulation via Cyclic di-AMP Signaling

A decade of research on the second messenger c-di-AMP

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