Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein

Zencir, Sevil; Ovee, Mohiuddin; Dobson, Melanie J.; Banerjee, Monimoy; Topçu, Zeki; Mohanty, Smita

doi:10.1016/j.bbrc.2011.07.029

Cited by 21 publications

(21 citation statements)

References 17 publications

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“…The PDZ-binding motif QTEV (GlnThr-Glu-Val) in BAI1 is indispensable for the interaction with BAP1 (150). BAI2 interacts with glutaminase-interacting protein (GIP), a 13.7-kD key PDZ domain-containing scaffold protein in the mammalian brain (151). In family II (EGF-TM7), only CD97 contains a PDZ-binding motif.…”

Section: Adhesion-gpcr Interactions Through Pdz-binding Motifsmentioning

confidence: 99%

“…(C) The split personality receptor model suggests that NTFs and CTFs of different Adhesion-GPCRs can be interchanged after GAIN domain cleavage and form functional hybrid receptors with inverted ligand or signaling specificity, respectively(82,83). (D) Assembly of multicomponent protein networks is permitted through the presence of protein adaptors such as a PDZ-binding motif (PDZm) at the C terminus of the intracellular tails of several Adhesion-GPCRs enabling the interaction with PDZ domain (PDZd)-containing proteins(23,148,150,151,154,155).…”

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confidence: 99%

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Sticky Signaling—Adhesion Class G Protein–Coupled Receptors Take the Stage

2013

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Adhesion-type heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane spanning (7TM) receptors with unusual layout and properties. The key to understanding the function of Adhesion-GPCRs appears to be their hybrid architecture: They have an extracellular domain containing an extended array of protein folds fit for interactions, and structural elements of GPCRs with a 7TM and an intracellular domain. If and how these distinct protein portions interact is currently under intense investigation. Intriguingly, all Adhesion-GPCRs have a juxtamembrane GPCR autoproteolysis-inducing domain that, in many homologs, facilitates the autocatalytic processing into an N-terminal fragment (NTF) and a C-terminal fragment (CTF), which subsequently remain attached at the cell surface. The NTF provides the ability for combinatorial engagement with cellular or matrix-associated molecules facilitating cell adhesion, orientation, and positioning during development, immune responses, and tumor growth. The CTF, like in canonical GPCRs, initiates interactions with different types of signaling molecules, including heterotrimeric G proteins, small guanosine triphosphatases, and transmembrane protein partners, yet the agonistic potential of most known Adhesion-GPCR ligands is uncertain. Studies with truncated receptors suggest that the NTF and CTF of Adhesion-GPCRs may function as autonomous adhesive and signaling units, respectively, but other studies in nonvertebrates demonstrating NTF-CTF interplay challenge this view. We discuss the available data concerning the main structural elements of Adhesion-GPCRs in the context of receptor function and signaling.

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Section: Adhesion-gpcr Interactions Through Pdz-binding Motifsmentioning

confidence: 99%

mentioning

confidence: 99%

Sticky Signaling—Adhesion Class G Protein–Coupled Receptors Take the Stage

2013

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“…TIP-1 involves in a wide spectrum of biological processes through selective protein interactions, such as beta-catenin [7], brain-specific angiogenesis inhibitor 2 [8], rhotekin [9], HPV16 E6 [10], HTLV-1 Tax [11], ARHGEF16 [12], potassium channel Kir2.3 [13], and glutaminase [14]. TIP-1 has been reported to regulate gastrulation movements during zebrafish embryo development [6].…”

Section: Introductionmentioning

confidence: 99%

Expression of Tax-interacting protein 1 (TIP-1) facilitates angiogenesis and tumor formation of human glioblastoma cells in nude mice

Han¹,

Wang²,

Zhang³

et al. 2013

Cancer Letters

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Glioblastoma is the most common and fatal type of primary brain tumors featured with hyperplastic blood vessels. Here, we performed meta-analyses of published data and established a correlation between high TIP-1 expression levels and the poor prognosis of glioblastoma patients. Next, we explored the biological relevance of TIP-1 expression in the pathogenesis of glioblastoma. By using orthotopic and heterotopic mouse models of human glioblastomas, this study has characterized TIP-1 as one contributing factor to the tumor-driven angiogenesis. In vitro and in vivo functional assays, along with biochemical analyses with microarrays and antibody arrays, have demonstrated that TIP-1 utilizes multiple pathways including modulating fibronectin gene expression and uPA protein secretion, to establish or maintain a pro-angiogenic microenvironment within human glioblastoma. In conclusion, this work supports the hypothesis that TIP-1 represents a novel prognostic biomarker and a therapeutic target of human glioblastoma.

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“…Many directly interacting proteins from the latest literatures in 2011 [48]–[57], which were not included in the training models, have been successfully predicted by SPPS server, as listed in Table 3.…”

Section: Resultsmentioning

confidence: 99%

SPPS: A Sequence-Based Method for Predicting Probability of Protein-Protein Interaction Partners

Liu

Huang

et al. 2012

PLoS ONE

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BackgroundThe molecular network sustained by different types of interactions among proteins is widely manifested as the fundamental driving force of cellular operations. Many biological functions are determined by the crosstalk between proteins rather than by the characteristics of their individual components. Thus, the searches for protein partners in global networks are imperative when attempting to address the principles of biology.ResultsWe have developed a web-based tool “Sequence-based Protein Partners Search” (SPPS) to explore interacting partners of proteins, by searching over a large repertoire of proteins across many species. SPPS provides a database containing more than 60,000 protein sequences with annotations and a protein-partner search engine in two modes (Single Query and Multiple Query). Two interacting proteins of human FBXO6 protein have been found using the service in the study. In addition, users can refine potential protein partner hits by using annotations and possible interactive network in the SPPS web server.ConclusionsSPPS provides a new type of tool to facilitate the identification of direct or indirect protein partners which may guide scientists on the investigation of new signaling pathways. The SPPS server is available to the public at http://mdl.shsmu.edu.cn/SPPS/.

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Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein

Cited by 21 publications

References 17 publications

Sticky Signaling—Adhesion Class G Protein–Coupled Receptors Take the Stage

Sticky Signaling—Adhesion Class G Protein–Coupled Receptors Take the Stage

Expression of Tax-interacting protein 1 (TIP-1) facilitates angiogenesis and tumor formation of human glioblastoma cells in nude mice

SPPS: A Sequence-Based Method for Predicting Probability of Protein-Protein Interaction Partners

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