Identification of axillary<i>Staphylococcus</i>sp. involved in the production of the malodorous thioalcohol 3-methyl-3-sufanylhexan-1-ol

Bawdon, Daniel; Cox, Diana S.; Ashford, David A.; James, A. Gordon; Thomas, Gavin H.

doi:10.1093/femsle/fnv111

Cited by 38 publications

(48 citation statements)

References 34 publications

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“…Members of the resident microbiota metabolize odorless sweat to malodorous compounds using hydrolytic enzyme activities, such as aminoacylase and cystathionin‐β‐lyase . While it was long believed that mainly corynebacteria produce body odor, recent cultivation‐independent studies suggest that also other groups are involved, such as anaerococci and staphylococci …”

Section: The Skin Microbiota In Health and Diseasementioning

confidence: 99%

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The Association of the Skin Microbiota With Health, Immunity, and Disease

Egert

Simmering

Riedel

2017

Clin Pharma and Therapeutics

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The human skin is densely colonized by a highly diverse microbiota comprising all three domains of life. Long believed to represent mainly a source of infection, the human skin microbiota is nowadays well accepted as an important driver of human (skin) health and well-being. This microbiota is influenced by many host and environmental factors and interacts closely with the skin immune system. Although cause and effect are usually difficult to discriminate, changes in the skin microbiota clearly play a role in the pathobiology of many types of skin disease and cosmetic disorders. Consequently, treatment and prevention strategies have to respect this role, rendering pre- and probiotic and even transplantation therapies an additional option to the use of antibiotics.

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Section: The Skin Microbiota In Health and Diseasementioning

confidence: 99%

“…10 While it was long believed that mainly corynebacteria produce body odor, recent cultivation-independent studies 58 suggest that also other groups are involved, such as anaerococci 60 and staphylococci. 61,62…”

Section: Protective Functions Of the Human Skin Microbiotamentioning

confidence: 99%

The Association of the Skin Microbiota With Health, Immunity, and Disease

Egert

Simmering

Riedel

2017

Clin Pharma and Therapeutics

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“…hominis and C . tuberculostearicum is that both strains produce specific malodorous thiol derivatives (Bawdon et al ., ) that were shown to affect A . gambiae responsiveness (Frei et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Identification of human skin bacteria attractive to the Asian Tiger mosquito

Michalet

Minard

Chevalier

et al. 2019

Environmental Microbiology

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Summary Aedes albopictus is a vector of arboviruses and filarial nematodes. Originating from Asia, this mosquito has rapidly expanded its geographical distribution and colonized areas across both temperate and tropical regions. Due to the increase in insecticide resistance, the use of environmentally friendly vector control methods is encouraged worldwide. Using methods based on semiochemicals in baited traps are promising for management of mosquito populations. Interestingly, human skin microbiota was shown to generate volatile compounds that attract the mosquito species Anopheles gambiae and Aedes aegypti. Here, we investigated the composition of skin bacteria from different volunteers and the attractive potential of individual isolates to nulliparous Ae. albopictus females. We showed that three out of 16 tested isolates were more attractive and two were more repulsive. We identified dodecenol as being preferentially produced by attractive isolates and 2‐methyl‐1‐butanol (and to a lesser extent 3‐methyl‐1‐butanol) as being overproduced by these isolates compared with the other ones. Those bacterial volatile organic compounds represent promising candidates but further studies are needed to evaluate their potential application for baited traps improvement.

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“…Recent research shows that Staphylococcus hominis , Corynebacterium tuberculostearicum and Anaerococcus spp. are important and abundant contributors to typical armpit malodour . More corynebacteria correlate with more body odour.…”

Section: Bacteria and Underarm Odourmentioning

confidence: 92%

Towards a bacterial treatment for armpit malodour

Callewaert

Lambert

Wiele

2017

Experimental Dermatology

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Fresh sweat does not smell. Bacteria inhabiting the underarm niche have a huge impact on odour formation. Apocrine secretions in the axillae contain long-chain fatty acids, fatty acids bound to amino acids, sulphur-containing amino acids and hormones, which are too large to become volatile. The bacterial degradation of these compounds leads to smaller compounds, which become volatile and have an odour.Depending on the type of bacteria living in the axillary region, that odour can smell foul. The microbiology of malodourous armpits is currently a topic of investigation. Mainly two genera are abundant in the axillary region: Staphylococcus and Corynebacterium spp.[1] Recent research shows that Staphylococcus hominis, Corynebacterium tuberculostearicum and Anaerococcus spp. are important and abundant contributors to typical armpit malodour. [2,3] More corynebacteria correlate with more body odour. Low-abundant species contribute likewise; however, it is still unclear which species and to what extent. As compared to the primate axillary microbiome, the human axillary microbiome is much less diverse, probably due to human hygiene habits.Repeated exposure to water, soaps, detergents and underarm cosmetics decrease the microbial load and diversity to a point where only the most adjusted bacterial genera survive. | BACTERIA UNDERNEATH THE AXILLARY SKIN SURFACEIt is still under debate whether bacteria can live underneath the skin surface, that is the sweat glands, hair follicles, sweat ducts, amongst others. There are nonetheless a number of reasons why living bacteria are present in these deeper skin regions. First, sweat glands and hair follicles are in contact with the outer skin epidermis through invagination, pores and dermal ducts. The sweat glands and hair follicles are large enough, warm and nutritiously rich to permit microbial activity.It is thus plausible that the degradation of the odour precursors starts from there. Second, bacteria were found with molecular techniques in the deeper layers of the stratum corneum of the epidermis. The microbiome of the deeper layers determined the recolonization process after skin barrier disruption.[4] Next to this, bacteria were microscopically observed in the duct of eccrine sweat glands in biopsy studies.A recent molecular investigation also detected bacteria in the dermis and even in the dermal adipose tissue of the skin.[5]Third, the axillary microbiome is quite stable over time. The armpits are regularly washed, and it would therefore be logic that the armpit microbiome shows much more variation over time. Without a microbiome living in the sweat glands and hair follicles, this would indeed be AbstractAxillary malodour is a frustrating condition for many people. It can lead to significant discomforts and various psychological effects. The underarm microbiome plays a major role in axillary malodour formation. Not only the bacteria on the epidermis, but also and especially those living in the sweat glands, sweat pores and hair follicles play a pivotal role in malodour d...

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Identification of axillaryStaphylococcussp. involved in the production of the malodorous thioalcohol 3-methyl-3-sufanylhexan-1-ol

Cited by 38 publications

References 34 publications

The Association of the Skin Microbiota With Health, Immunity, and Disease

The Association of the Skin Microbiota With Health, Immunity, and Disease

Identification of human skin bacteria attractive to the Asian Tiger mosquito

Towards a bacterial treatment for armpit malodour

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