Identification of Autoantibodies to a Pancreatic Antigen in Patients with Idiopathic Chronic Pancreatitis and Sjögrenʼs Syndrome

Nishimori, Isao; Yamamoto, Yoichi; Okazaki, Kazuichi; Morita, Masanori; Onodera, Machi; Kino, Junko; Tamura, Shinji

doi:10.1097/00006676-199405000-00015

Cited by 58 publications

(28 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pancreatitis is occasionally associated with certain autoimmune diseases, such as systemic lupus erythematosus, primary biliary cirrhosis, and Sjogren's syndrome (33). Recently, Haspel et al (34) proposed the concept of "multiple organ autoimmunity," based on the existence of monoclonal multiple organ-reactive autoantibodies or autoantibodies with a common antigenic determinant on different molecules in multiple organs.…”

Section: Discussionmentioning

confidence: 99%

Loss of TGF-β signaling contributes to autoimmune pancreatitis

Hahm

Lee

et al. 2000

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Loss of TGF-β signaling contributes to autoimmune pancreatitis

Hahm

Lee

et al. 2000

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…The existence of autoantibodies in SS patients' serum to an antigen expressed in ductal cells of exocrine glands has been shown (14). This antigen was identified to belong to carbonic anhydrase family.…”

Section: Discussionmentioning

confidence: 99%

Immunization of Balb/c mice with modified auto-antigens for induction of autoimmune sialoadenitis

2007

View full text Add to dashboard Cite

Sjögren's syndrome is an autoimmune disease characterized by sialoadenitis and elevated titers of autoantibodies. To assess whether it is possible to induce inflammatory changes in salivary gland tissues, a series of immunizations in Balb/c mice have been undertaken, using salivary gland extract, modified or not, added to several adjuvants. Mice's humoral immune response to salivary gland antigens was monitored by ELISA. Inflammatory cells infiltrating gland tissue were seen 3 months after immunization with salivary gland extract modified with pepsin (AgGp) and metaperiodate (AgGMp). Although pathological progression was not observed, the histopathological picture was similar to the initial phase of Sjögren's syndrome. In addition, a monoclonal antibody reactive with 3 gland polypeptides and anhydrase carbonic II was rescued among B cells from immunized mice. Thus, immunizations with modified autoantigens were able to initiate pathological damage to glandular tissue and stimulate the proliferation of auto-reactive B cells.

show abstract

“…In Sjogren's syndrome several autoantibodies, including SS-A, SS-B and a-fodorin, have been identified as disease-related antibodies (1). Amongthem the antibody to carbonic anhydrase II was occasionally detectable in the sera of patients with this disease (7,15,16), although it was also found in the sera of patients with other collagen diseases: systemic lupus erythematosus, progressive systemic sclerosis and dermatomyositis (17). Originally, carbonic anhydrase II was reported to be an enzyme of an interspecies cross-reactive antigen (15), and its histological localization was shownto be in the ducts of a variety of exocrine glands, including salivary, lacrimal and pancreatic glands, the biliary tract and uriniferous distal tubles ( 16).…”

Section: Discussionmentioning

confidence: 99%

A Primary Sjoegren's Syndrome Patient with Marked Swelling of Multiple Exocrine Glands and Selerosing Pancreatitis.

et al. 2002

Self Cite

View full text Add to dashboard Cite

A 55-year-old man suffered from nasal obstruction, swelling of the salivary glands, and diplopia caused by markedly enlarged lacrimal glands. The diagnosis of primary Sjogren's syndromewas madeby a positive Schirmer's test and nasal mucosal biopsy with severe lymphocyte infiltration. He was also found to have swelling of the whole pancreas and increased wall thickness in the commonbile duct and the gall bladder. His serum was positive for an anticarbonic anhydrase II antibody. Since carbonic anhydrase II is present in the ductal cells of various exocrine organs, this autoantibody is considered to be related to the pathogenesis of primary Sjogren's syndrome with a marked swelling of multiple exocrine organs. (Internal Medicine 41 : 749-753, 2002)

show abstract

Identification of Autoantibodies to a Pancreatic Antigen in Patients with Idiopathic Chronic Pancreatitis and Sjögrenʼs Syndrome

Cited by 58 publications

References 11 publications

Loss of TGF-β signaling contributes to autoimmune pancreatitis

Loss of TGF-β signaling contributes to autoimmune pancreatitis

Immunization of Balb/c mice with modified auto-antigens for induction of autoimmune sialoadenitis

A Primary Sjoegren's Syndrome Patient with Marked Swelling of Multiple Exocrine Glands and Selerosing Pancreatitis.

Contact Info

Product

Resources

About