Identification of Asparagusic Acid as a Nematicide Occurring Naturally in the Roots of Asparagus

Takasugi, Mitsuo; Yachida, Y.; Anetai, Masaki; Masamune, Tadashi; Kegasawa, Kazuo

doi:10.1246/cl.1975.43

Cited by 40 publications

(18 citation statements)

References 4 publications

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“…This compound inhibited hatching of H. glycines and G. rostochinensis, and induced mortality in three other nematode species at 50µg/ml [198].…”

Section: Other Compoundsmentioning

confidence: 96%

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Secondary Metabolites with Antinematodal Activity from Higher Plants

Zhou¹,

Wang²,

Wang³

et al. 2012

Studies in Natural Products Chemistry

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“…This compound inhibited hatching of H. glycines and G. rostochinensis, and induced mortality in three other nematode species at 50µg/ml [198].…”

Section: Other Compoundsmentioning

confidence: 96%

“…Three antinematodal coumarins namely 8-geranyloxypsoralen (197), imperatorin (198), and heraclenin (199) were obtained from the extract of Heracleum candicans (Umbelliferae). The median lethal concentrations (LC 50 ) of the compounds at 72h were 188.3µg/ml, 161.7µg/ml and 114.7µg/ml, respectively against B. xylophilus [142].…”

Section: Coumarinsmentioning

confidence: 99%

Secondary Metabolites with Antinematodal Activity from Higher Plants

Zhou¹,

Wang²,

Wang³

et al. 2012

Studies in Natural Products Chemistry

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“…It inhibited hatching of the soybean cyst nematode (Heterodera glycines) and G. rostochiensis at 50 p.g/ml, even in the presence of hatching stimulants. The same concentration resulted in 80-99% mortality in Meloidogyne hapla, Pratylenchus penetrans, and the pin nematode Paratylenchus curvitatus (66). Another species of asparagus, A. adescendens, contained several glycosides, e.g., asparanin B (L), which inhibited motility of M. javanica at 200 ng/ml (67).…”

Section: Many Additional Compounds (Figure 8) Possess Antagonism Towamentioning

confidence: 99%

Naturally Occurring Nematicides

Chitwood¹

1993

ACS Symposium Series

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This review of naturally occurring phytochemicals with biological activity against plant-parasitic nematodes focuses on several diverse classes of compounds, including polythienyls, alkaloids, phenolics, polyacetylenes, fatty acids, terpenoids, and others. The nematotoxic mode of action and physiological role of most of these compounds in plants are unknown, although some are synthesized in response to nematode infection. Only a few plant families, primarily the Asteraceae and Fabaceae, have been examined for existence of nematotoxic substances. In a few cases, synthetic analogs of naturally occurring compounds have been synthesized and have possessed stronger biological activity than the naturally occurring ones. Enhanced research and development of phytochemical nematicides and analogs could provide safe, selective compounds for minimizing the multibillion dollar annual losses inflicted by phytoparasitic nematodes in the U.S. Currently available chemicals for management of phytoparasitic nematodes are not only expensive but can also adversely affect the environment or human health (1-3). Consequently, several nematicides have been deregistered or restricted in use during the past decade, and others could face similar restrictions. Because phytoparasitic nematodes inflict annual agricultural losses of 6 billion dollars in the U.S. and 77 billion dollars in the world (4), better management tools are needed urgently.Because higher plants could be expected to be a rich reservoir of interesting compounds with biological activity against phytoparasitic nematodes, isolation and identification of naturally occurring phytochemicals with biological activity against nematodes would be a logical first step for development of new, environmentally safe nematicides. Indeed, higher plants are being increasingly examined as sources for novel compounds with activity against animal-parasitic This chapter not subject to U.S.

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“…glycines, and Meloidogyne hapla, and is considered to be a major factor in natural resist ance of asparagus (38). Asparagusic acid, its syn and anti Soxide (39) and some related acyclic derivatives are also very effective plant growth inhibitors.…”

Section: Asparagusic Acid 22 Present To the Extent Of About 35 Ppm mentioning

confidence: 99%

Low-Molecular-Weight Organosulfur Compounds in Nature: The Search for New Pesticides

Block

1981

ACS Symposium Series

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A rich variety of organosulfur compounds are found in living systems. A list of biochemically notable organosulfur compounds would include, among others, the essential amino acids cysteine and methionine, peptides such as glutathione, and the recently characterized biologically extremely potent glutathione deriva tive leukotriene C-1 (1)(1) (Fig. 1) (the "slow reacting substance" of anaphylaxis (SRS) which is known for its role in the lungs during asthma attacks), polycyclic peptide antibiotics such as bacitracin, gliotoxin, cephalosporin, penicillin, and the recently discovered β-lactam antibiotic thienamycin (2)(2), cofactors and vitamins such as thiamine, biotin, coenzyme A and α-lipoic acid, a bio logical alkylating agent, S-adenosylmethionine, the biological redox systems ferredoxin and rubredoxin and sulfur-containing bases found in bacterial transfer-RNA such as 4-thiouracil (3).A remarkable range of simpler organosulfur compounds are known to be widely distributed throughout the plant kingdom (3,4,5,6). These compounds often make important contributions to the odor and flavor of many of the common comestibles. In some instances these sulfur compounds may also serve by their odor and taste to repel predators or to act for the plant as resistance factors against infection by microorganisms (e.g. as natural pest icides). Not to be outdone, some insects such as the onionmaggot, Hylemya antiqua, and turnip (or vegetable) weevil, Listroderes obliquas, have evolved so that some of the same organosulfur compounds act as attractants and stimulate egg laying and biting (Z)A number of insects and higher animals have also been found to possess unusual small organosulfur molecules which may serve as defensive secretions, sex attractants, or scent markers · In many cases the low molecular weight organosulfur compounds occur in plants (and possibly in animals as well) in an odorless com bined form (e.g., as peptides or glycosides) and are released enzymatically when the tissue is injured or stimulated, i.e. during attack by a predator. Finally it should be noted that certain sulfur compounds reported to be of natural origin may 0097-6156/81/015 8-0003$05.00/0

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Identification of Asparagusic Acid as a Nematicide Occurring Naturally in the Roots of Asparagus

Cited by 40 publications

References 4 publications

Secondary Metabolites with Antinematodal Activity from Higher Plants

Secondary Metabolites with Antinematodal Activity from Higher Plants

Naturally Occurring Nematicides

Low-Molecular-Weight Organosulfur Compounds in Nature: The Search for New Pesticides

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