Identification of Application and Interpretation Errors that Can Occur in Pairwise Meta-Analyses in Systematic Reviews of Interventions: A Systematic Review

PeRinatal, neOnatal, and Maternal OuTcomEs with azithromycin prophylaxis in pregnancy and labour (PROMOTE-PROPHYLAXIS): systematic review and meta-analysis

“…To assess heterogeneity, we used the I-squared, Q-test, prediction interval, 35 tau and tau-squared values, 35 avoiding reliance on just a single metric. 36 , 37 I-squared uses a Q-test to inform what portion of the variability in results is attributed to between-study heterogeneity [ Box S1 ]. We explored heterogeneity using subgroup analyses-based on comparator (placebo/standard of care and active antibiotics) and mode of delivery (vaginal or caesarean section).…”